Aerial view of University of Michigan Health hospital in Ann Arbor, Michigan.

Lupus Research Program

The U-M Medical School Lupus Program is home to world-class patient care, research endeavors, education, and training opportunities. Our multidisciplinary team of researchers and health care providers strive to develop the latest ides in lupus biology and bring them to the forefront of patient care. Since our program founding in 2007 we have led the way to improve patients’ lives. 

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About the Program

Our comprehensive patient care environment extends from within the main medical campus to our satellite clinics around the area. We work to collaborate with out specialist physicians to assist in coordinating medical testing. Our outpatient facilities are designed and administered to ensure personal, professional, and attentive care for patients with lupus and related autoimmune diseases. Our interdisciplinary research and patient care conferences allow for multi-specialist input into disease management.

Our researchers are world-leaders in basic, translational, and clinical research. The program facilitates advances in the treatment of lupus by fostering continued development of an interdisciplinary group of physicians and physician scientist researchers focused on SLE and its impact. Clinical trial coordinators supported by the Lupus Program bring knowledge of available clinical trials to our patients to offer opportunities for the latest, most effective therapies.

Our program proudly serves as a resource for the training of physicians and medical students to better serve our community. A dedicated lupus clinical rotation for our fellows ensure we will continue to train the next generation of experts in lupus care. 

Contact Us

Administrative Office
University of Michigan Lupus Program
300 North Ingalls Street, SPC 5422
Ann Arbor, MI 48109-5422

Non-patient related calls only

Phone: 734-936-5561

Lupus Program Research

We are on the verge of a treatment revolution for lupus patients. Lupus in an autoimmune disorder, meaning that the body’s own immune system can harm healthy cells and tissues. This disorder can affect many body parts, including the joints, skin, kidneys, heart, blood vessels, lungs, and brain. Lupus patients can experience periods of wellness (remissions) and periods of active disease (flares). Permanent organ damage may result from both flares and the side effects of treatments. However, we can change this narrative! 

The University of Michigan Lupus Program is dedicated to learning more about what causes lupus, how flares can be reduced or prevented, how to predict disease progression and activity, and how to prevent permanent organ damage. Research is critical to find new prevention and treatment strategies. 

  • Lab of J. Michelle Kahlenberg, MD, PhD – Learn more about Dr. Kahlenbergs’s research here
  • Lab of Johann Gudjonsson, MD, PhD – Learn more about Dr. Gudjonsson’s research here
  • Lab of Allison Billi, MD – Learn more about Dr. Billi’s research here
  • Lab of Jason Knight, MD, PhD– Learn more about Dr. Knights’s research here

Clinical Trials:

Clinical trials assess new treatments or diagnostic tests. They help to achieve a better understanding of the disease that is being investigated and determine the effectiveness and safety of new treatments.

Our group is a member of the Lupus Clinical Investigators Network (LuCIN), a nation-wide team of lupus programs working to bring the most promising new therapies to lupus patients. We are a site for clinical trials for many different aspects of lupus, giving our patients the opportunity to receive promising new treatments or participate in new diagnostic procedures. Participation is completely voluntary.  Please see below for a list of our current clinical trials

Observational Studies & Clinical Registries: 

Observational studies are done to observe a patient’s disease, symptoms, and lived experience of their disease over time without introducing an intervention, such as a medication. Our program has multiple observational studies, and we welcome patients to participate at all stages of disease. Some of our observational studies involve participation in registries where samples of blood, urine, and/or skin may be collected on a voluntary basis. Many studies also include the collection of self-reported data to evaluate symptoms and impact on quality of life from the patient’s perspective.

Outreach & Engagement

  • Conquer Lupus: A place were warriors and their communities can find resources for living with lupus.
  • Event Spotlight: Ann Arbor Lupus Medical Symposium
    Saturday, April 11, 2026
    The Vanguard, Ann Arbor, MI

Meet our Team

The Lupus Program - led by Director, J. Michelle Kahlenberg, MD, PhD - consists of a multidisciplinary group of health care professionals. In addition to our rheumatologists, the program includes faculty from dermatology, hematology, nephrology, obstetrics and gynecology, psychiatry and pulmonology.

Program Leadership

Michelle Kahlenberg

J Michelle Kahlenberg MD, PhD

Michael H and Marcia S Klein Professor of Rheumatic Diseases
Associate Chair, Department of Internal Medicine
Professor of Internal Medicine and Professor of Dermatology
Medical School

Patient Care

For Patients

For Physicians

Support Our Work

Due to the generosity of our many strong supporters, the Lupus Program is able to continue its efforts to learn more about what causes lupus and discover new treatment options. Our donors are critical to moving lupus research forward.

How to Donate

To make a gift, please visit the below online giving pages:

Video: Meet Our Experts

Watch a video featuring our Lupus Program team of experts, who are committed to providing excellence in patient care and conducting cutting-edge research.

Watch video

Featured News & Stories

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Health Lab

Decoding mechanisms of photosensitivity in autoimmune diseases

Photosensitivity is a common occurrence in patients with autoimmune disorders, especially lupus and dermatomyositis. The only treatment for this currently is diligent sunscreen use, but research is leading to new insights in how photosensitivity is created on a cellular level.
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Health Lab

Topical Mupirocin lowers lupus inflammation

J. Michelle Kahlenberg, M.D., Ph.D., led a team of researchers looking at an alternative treatment for lupus rashes with a topical treatment called mupirocin. 
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The Fundamentals

From Patients to Progress: Advancing Autoimmune Research

Today on The Fundamentals, our guest is Dr. Michelle Kahlenberg, an Associate Professor of Internal Medicine and Dermatology, the Giles Bole and Dorothy Mulkey Research Professor of Rheumatology and the Vice Chair for Basic and Translational Research in Internal Medicine. Her clinical work is centered on the care of patients with lupus, including those with refractory skin disease. In addition to running her lab, she's an active member of the Immunology Training Program and has received national recognition for her research.