William J McCune
Michael H and Marcia S Klein Professor of Rheumatic Diseases
Professor of Internal Medicine
[email protected]

Available to mentor

William J McCune
Professor
  • Research Overview
  • Links
  • Recent Publications
  • Research Overview

    Dr. McCune's research includes the following: 1) The "MiLES Project," a large epidemiologic study to determine the incidence and prevalence of systemic lupus in southeastern Michigan within two defined geographic areas: Wayne and Washtenaw counties. 2) Cardiovascular studies in women with systemic lupus. This is a cross-sectional and longitudinal study of cardiovascular risk factors and the evolution of surrogate markers of cardiovascular disease in women with systemic lupus using both functional and anatomical measures of vascular injury. In collaboration with Mariana Kaplan, MD, Dr. McCune's group is performing sophisticated studies of the interplay between lupus activity, cardiovascular risk factors, and the life cycle of endothelial cells, which is perturbed in active lupus in ways that are likely to lead to accelerated atherosclerosis. 3) Cardiovascular effects of DHEA in systemic lupus: This is a randomized crossover trial assessing the effects of DHEA on cardiovascular function and biomarkers of cardiovascular risk. 4) Lupus Clinical Trials Consortium: This is a multicenter consortium designed to provide infrastructure for performing lupus clinical trials and supports a clinical trials coordinator as well as ongoing clinical research. 5) Randomized clinical trials of rituximab in systemic lupus: This is a site for two multicenter trials of rituximab in systemic lupus, one for moderate to severe lupus, and one for nephritis. 6) Anti-BLyS antibodies in systemic lupus: This is a multicenter trial assessing the effects of monoclonal anti-BLyS antibody in patients with moderate to severe lupus. 7) Advanced magnetic resonance imaging in neuropsychiatric lupus: This is a longitudinal study to assess the utility of sophisticated imaging processes such as diffusion weighted tensor imaging in assessing cerebral damage in neuropsychiatric lupus and predicting long term outcome.

    Links
    • Rheumatology Lupus Program
    Recent Publications See All Publications
    • Journal Article
      Mycophenolate mofetil withdrawal in patients with systemic lupus erythematosus: a multicentre, open-label, randomised controlled trial.
      Chakravarty EF, Utset T, Kamen DL, Contreras G, McCune WJ, Aranow C, Kalunian K, Massarotti E, Clowse MEB, Rovin BH, Lim SS, Majithia V, Dall'Era M, Looney RJ, Erkan D, Saxena A, Olsen NJ, Ko K, Guthridge JM, Goldmuntz E, Springer J, D'Aveta C, Keyes-Elstein L, Barry B, Pinckney A, McNamara J, James JA. Lancet Rheumatol, 2024 Mar; 6 (3): e168 - e177. DOI:10.1016/S2665-9913(23)00320-X
      PMID: 38301682
    • Journal Article
      Associations between CD70 methylation of T cell DNA and age in adults with systemic lupus erythematosus and population controls: The Michigan Lupus Epidemiology & Surveillance (MILES) Program.
      Somers EC, Goodrich JM, Wang L, Harlow SD, Marder W, Hassett AL, Zick SM, McCune WJ, Gordon C, Barbour KE, Helmick CG, Strickland FM. J Autoimmun, 2023 Dec 7; 142: 103137 DOI:10.1016/j.jaut.2023.103137
      PMID: 38064919
    • Journal Article
      Cost-related prescription non-adherence and patient-reported outcomes in systemic lupus erythematosus: The Michigan Lupus Epidemiology & Surveillance program.
      Minhas D, Marder W, Hassett AL, Zick SM, Gordon C, Harlow SD, Wang L, Barbour KE, Helmick CG, McCune WJ, Somers EC. Lupus, 2023 Aug; 32 (9): 1075 - 1083. DOI:10.1177/09612033231186113
      PMID: 37378450
    • Journal Article
      Activation of a Latent Epitope Causing Differential Binding of Antineutrophil Cytoplasmic Antibodies to Proteinase 3.
      Casal Moura M, Thompson GE, Nelson DR, Fussner LA, Hummel AM, Jenne DE, Emerling D, Fervenza FC, Kallenberg CGM, Langford CA, McCune WJ, Merkel PA, Monach PA, Seo P, Spiera RF, St Clair EW, Ytterberg SR, Stone JH, Robinson WH, Specks U, WGET and RAVE-ITN Research Groups . Arthritis Rheumatol, 2023 May; 75 (5): 748 - 759. DOI:10.1002/art.42418
      PMID: 36515151
    • Journal Article
      Glucocorticoid-induced osteoporosis in premenopausal women: management for the rheumatologist.
      Chakrabarti K, McCune WJ. Curr Opin Rheumatol, 2023 May 1; 35 (3): 161 - 169. DOI:10.1097/BOR.0000000000000934
      PMID: 36943706
    • Journal Article
      Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature.
      Coit P, Roopnarinesingh X, Ortiz-Fernández L, McKinnon-Maksimowicz K, Lewis EE, Merrill JT, McCune WJ, Wren JD, Sawalha AH. Ann Rheum Dis, 2022 Oct; 81 (10): 1428 - 1437. DOI:10.1136/annrheumdis-2022-222656
      PMID: 35710306
    • Journal Article
      Advances in the clinical use of hydroxychloroquine levels.
      Chakrabarti K, McCune WJ. Curr Opin Rheumatol, 2022 May 1; 34 (3): 151 - 157. DOI:10.1097/BOR.0000000000000872
      PMID: 35440530
    • Preprint
      Hypomethylation of miR-17-92 cluster in lupus T cells and no significant role for genetic factors in the lupus-associated DNA methylation signature
      Coit P, Roopnarinesingh X, Ortiz-Fernandez L, Maksimowicz-McKinnon K, Lewis EE, Merrill JT, McCune WJ, Wren JD, Sawalha AH. medRxiv, DOI:10.1101/2022.02.21.22271293