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Morphology & Imaging Core

The Morphology & Imaging Core in the U-M Medical School Department of Ophthalmology & Visual Sciences provides specialized histology services for vision researchers, focusing on the processing of ocular and brain tissues. We support investigators through expert sample preparation, publication-quality imaging assistance and technical training.

For More Information

Project Priorities
Comprehensive Tissue Processing
Imaging Analysis & Publication Support
Technical Training & Consultation

Our Services
  • Process ocular and brain tissues for light microscopy, immunocytochemistry and in situ hybridization.
  • Prepare and fix specimens for electron microscopy to be analyzed at other facilities.
  • Provide training in tissue processing, microtomy, staining, and immunohistological techniques.
  • Assist with image analysis and the production of publication-quality figures.

Contact

Brad Nelson, Manager/Technician
Email: [email protected]
Phone: 734-615-7991
Fax: 734-936-3815

Check the status of a work order

Reserve equipment

Instrumentation

Note: Some pieces of equipment must be reserved for use. Reserve equipment

  • Cryostar NX50 Cryostat
  • Leica CM3050 Cryostat
  • Lecia CM3050S disposable blade cryostat
  • Reichert steel knife sharpener
  • Leitz rotary microtome for plastic sectioning
  • Tissue-Tek Paraffin processing and embedding station
  • Access to Shandon AS 325 paraffin microtome
  • Shandon Tissue Processor Embedding Station
  • Standard light level biological stains and staining setup available
  • Two research-quality Leica DM 6000 microscopes with 2X-100X objectives, differential interference contrast optics (DIC), and transmitted and epi-fluorescence light sources. The microscope is fitted with duel digital cameras (greyscale for fluorescence, color for high resolution color stain) and interfaced with an HP computer with Leica’s LAS-X for image capture and analysis.
  • Epson Expression 1680 Flatbed scanner with dedicated G5 iMac running Adobe Creative suite (Adobe Photoshop, Illustrator, In-Design with PageMaker plug-in, Acrobat and Go-Live). Also, Microsoft Office X, and OCR software
  • Nikon Super Coolscan 5000ED slide scanner, also associated with a G5 iMac
  • Access to the UM Microscopy and Image Analysis Laboratory (MIAL) in the Department of Cell and Developmental Biology for use of a BioRad or Zeiss laser scanning confocal microscope and a Philips transmission electron microscope
  • Olympus EX51 Microscope
  • Leica 205FA Fluorecence Stereo Microscope
  • Leica MetaMorph & LAS-AF Offline Imaging Workstation
  • Leica SP5 Confocal Microscope
  • Leica SPX5 2-Photon Laser-Scanning Confocal Microscope
  • LMD7000 Laser Micro dissection Microscope

Equipment Reservation Calendars

Note: Log into the MiCores reservation calendar site to view these calendars.

Core Director
See all Ophthalmology & Visual Sciences faculty Jillian N. Pearring

Jillian N Pearring, PhD
Skillman Early Career Professor of Pediatric Ophthalmology
Associate Professor of Ophthalmology and Visual Sciences
Associate Professor of Cell and Developmental Biology
Medical School