We investigate:

• Intracellular signaling mechanisms regulating T cell development and activation
• Immunoglobulin class switch recombination in B cells using techniques such as bacterial artificial chromosome transgenesis
• The behavior of T cells as regulators of adaptive immune responses and as effector cells is examined in bacterial infection and organ transplantation models using combined cellular and molecular approaches.
• The mechanisms involved in processing of antigen for recognition by T cells, including intracellular assembly of major histocompatibility complex class I proteins, and their altered trafficking in virus-infected cells

We are using the latest techniques and technology, including genome engineering methods.