Laboratory equipment in the DCMB
4D Nucleome

4D nucleome research analyzes the 3D spatial organization of DNA, RNA, and protein in the nucleus of cells, over time (4D). This research yields further insights into the interactions among these components and how they influence various cellular behaviors, including regulation processes along the DNA-RNA-protein production chain.  

This research answers foundational questions toward a better understanding of normal and dysfunctional biological processes that lead to diseases, at the cellular level. 

This research overlaps with the study of Genomics, regulatory genomics and epigenomics and of the Application to complex genetic diseases. 

The following DCMB faculty members work in this area. 
Associated Faculty
Brian Athey Brian D Athey, PhD
Michael Savageau Collegiate Professor
Chair
Department of Computational Medicine and Bioinformatics
Professor of Computational Medicine and Bioinformatics
Professor of Psychiatry
Medical School
Minji Kim Minji Kim, PhD
Assistant Professor of Computational Medicine and Bioinformatics
Medical School
Jie Liu Jie Liu, PhD
Associate Professor of Computational Medicine and Bioinformatics, Medical School
Associate Professor of Electrical Engineering and Computer Science, College of Engineering
Indika Rajapakse Indika Rajapakse, PhD
Professor of Computational Medicine and Bioinformatics
Medical School
Professor of Mathematics
College of Literature, Science, and the Arts
Joshua Welch Joshua Welch, PhD
Associate Professor of Computational Medicine and Bioinformatics, Medical School
Associate Professor of Electrical Engineering and Computer Science, College of Engineering