Laboratory equipment in the DCMB
4D Nucleome

4D nucleome research analyzes the 3D spatial organization of DNA, RNA, and protein in the nucleus of cells, over time (4D). This research yields further insights into the interactions among these components and how they influence various cellular behaviors, including regulation processes along the DNA-RNA-protein production chain.  

This research answers foundational questions toward a better understanding of normal and dysfunctional biological processes that lead to diseases, at the cellular level. 

This research overlaps with the study of Genomics, regulatory genomics and epigenomics and of the Application to complex genetic diseases

The following DCMB faculty members work in this area. 

Associated Faculty
Brian Athey Brian D Athey, PhD
Michael Savageau Collegiate Professor
Chair, Department of Computational Medicine and Bioinformatics
Professor of Computational Medicine and Bioinformatics
Professor of Psychiatry
Minji Kim Minji Kim, PhD
Assistant Professor of Computational Medicine and Bioinformatics
Jie Liu Jie Liu, PhD
Assistant Professor of Computational Medicine and Bioinformatics
Assistant Professor of Electrical Engineering and Computer Science
Rajapakse-Indika.jpeg Indika Rajapakse, PhD
Professor of Computational Medicine and Bioinformatics
Professor of Mathematics
College of Literature, Science, and the Arts
Joshua Welch Joshua Welch, PhD
Associate Professor of Computational Medicine and Bioinformatics
Associate Professor of Electrical Engineering and Computer Science