Stroke Program

The Stroke Program has a broad research agenda from molecular biology to community based participatory research. Researchers are investigating genetic syndromes that pre-dispose to stroke syndromes. Vascular biology and possible neuro-toxicities of medications used to treat stroke are also being investigated.

A Focus on Health Disparities

The group has a fundamental interest in health disparities and uses the disease stroke as a common, expensive and severe model disease to look at the impact on minority populations and women. The U-M Stroke Program is the home of two stroke surveillance studies: the Brain Attack Surveillance in Corpus Christi (BASIC) and the Greater Cincinnati/Northern Kentucky Stroke Study. In addition to epidemiology, behavioral interventions are conducted by the group to reduce the impact of disease, particularly through a community-based participatory research approach in partnership with the Flint community.

The intersection of sleep apnea and stroke is a critically important research focus of the stroke group. The role of sleep apnea as an explanatory variable in health disparities is a part of this investigation. In addition, the U-M Stroke and Sleep Medicine Programs are conducting a definitive trial, called Sleep SMART, to evaluate whether treating sleep apnea reduces post-stroke disability or helps prevent another stroke, ACS, or death. Finally, the team is exploring the role of stroke and dementia and brain health.

Healthcare Resource Utilization and Cost-Effectiveness Research

A third focus of the research group is health care resource utilization and cost-effectiveness studies looking at the prevention, treatment and recovery from stroke. These efforts are intended to provide a scientific basis for rational health care decision making.

National and Regional Leadership

An NINDS funded Emergency Neurology Clinical Trials Network is a prominent focus of our work. The University of Michigan is also a Regional Coordinating Center for the NINDS-funded StrokeNet. We are supported by numerous NIH and American Heart Association Awards.

BASIC Sleep & Sleep Apnea Projects

Our group has investigated multiple aspects of sleep apnea and sleep.

BASIC Project

Our research addresses critical issues specific to stroke in the areas of prevention, treatment, education, and advocacy.


NIH-funded project in collaboration with the University of Michigan and the Diocese of Corpus Christi.

NIH-Funded Clinical Trials in Stroke

As a Regional Coordinating Center as part of StrokeNet, the University of Michigan participates in NIH-funded trials including acute stroke, prevention, and rehabilitation/recovery trials. We currently participate in the following:

Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke
Site Principal Investigator: Joe Carrera, MD

Anticoagulation in ICH Survivors for Prevention and Recovery
Site Principal Investigator: Aditya Pandey, MD

Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis
Site Principal Inestigator: Nick Osborne, MD, MS

Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation
Site Principal Investigator: Jessica Pruente, MD

Mult-Arm Optimization of Stroke Thrombolysis
Site Principal Investigator: Cemal Sozener, MD, M.Eng.

Statins Use in intracerebral hemorrhage patients
Site Principal Investigator: Aditya Pandey, MD

Sleep for Stroke Management and Recovery Trial
Primary Principal Investigators and event adjudicators are at the University of Michigan