diagram of genomes
Genome Structure & Function

Our genome is intricately structured at multiple levels in the cell. However, how these structural aspects affect cellular function and cause disease is largely unknown. 

Our researchers are uncovering these mysteries of our genome by employing cutting-edge experimental and computational approaches. Our work encompasses the realms of basic, applied and clinical research. For example, we investigate: the molecular mechanisms driving de novo variants in germ cells; how ‘jumping genes’ or retrotransposons affect the structure our genome function; and how transcriptional regulatory elements direct gene expression at the proper time and space. 

We also develop and employ cutting-edge approaches to address these questions including novel single-cell genomics,  and super-resolution microscopy, nascent RNA sequencing, massively parallel mutagenesis, and transcriptional assays with big data analysis tools.

Please browse the profiles of the Evolutionary & Population Genetics faculty below to explore the research of individual laboratories.

Principal Investigators
Anthony Antonellis headshot Anthony Antonellis
James V Neel Collegiate Professor of Human Genetics
Professor of Human Genetics
Chair, Department of Human Genetics
Professor of Neurology
Alan Boyle Alan P Boyle, PhD
Associate Professor of Computational Medicine and Bioinformatics
Associate Professor of Human Genetics
MPHOTO-HumnGeneticsHdsGrps24(130) Margit Burmeister, PhD
Associate Chair, Department of Computational Medicine and Bioinformatics
Program Director, Bioinformatics Graduate Program
Professor of Human Genetics
Professor of Psychiatry
Research Professor, Michigan Neuroscience Institute and Professor of Computational Medicine and Bioinformatics
Sally Camper Sally A Camper
Margery Shaw Distinguished University Professor of Human Genetics and Internal Medicine
Professor of Human Genetics
Professor of Internal Medicine
David Ginsburg headshot David Ginsburg
James V Neel Distinguished University Professor of Internal Medicine and Human Genetics
Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Internal Medicine
Professor of Human Genetics
Professor of Pediatrics
Research Professor
Life Sciences Institute
HmGenFcltyHdsGrps21(117) Saher S Hammoud
Associate Professor of Human Genetics
Associate Professor of Urology
Associate Professor of Obstetrics and Gynecology
Shigeki Iwase Shigeki Iwase PhD
Associate Professor of Human Genetics
Associate Professor of Pediatrics
Sundeep Kalantry, PhD Sundeep Kalantry
Professor
Jacob Kitzman headshot Jacob Kitzman, PhD
Associate Professor of Human Genetics
Associate Professor of Computational Medicine and Bioinformatics
labcoat Jeffrey Kidd
Professor of Human Genetics
Professor of Computational Medicine and Bioinformatics
Kenneth Kwan Kenneth Kwan
Associate Professor of Human Genetics and Research
Associate Professor
Michigan Neuroscience Institute
Lukaszewicz,-Agnieszka_2023.jpg Agnieszka Lukaszewicz
Assistant Professor
MPHOTO-HumnGeneticsHdsGrps24(323) Hayley S McLoughlin, PhD
Assistant Professor of Neurology
Assistant Professor of Human Genetics
HumanGenStffHdsGrps22(212) Miriam H Meisler
Myron Levine Distinguished University Professor of Human Genetics
Professor of Human Genetics
Professor of Neurology
Ryan Mills Ryan E Mills, PhD
Program Director of DCMB Computing Infrastructure
Professor of Computational Medicine and Bioinformatics
Professor of Human Genetics
HumanGenStffHdsGrps22(288).jpg John V Moran
Gilbert S Omenn Collegiate Professor of Human Genetics
Professor of Human Genetics and Professor of Internal Medicine
Program Associate
PhD Graduate Program in Genetics and Genomics
S_Moon.jpg Stephanie L Moon
Assistant Professor of Human Genetics
J_Mueller.jpg Jacob L Mueller
Associate Professor of Human Genetics
Associate Chair, Department of Human Genetics
Program Director, Human Genetics
Associate Professor of Obstetrics and Gynecology
Associate Professor of Urology
Xander Nuttle Xander Nuttle
Assistant Professor of Human Genetics
Steven Parker Stephen CJ Parker, PhD
Professor of Computational Medicine and Bioinformatics
Professor of Human Genetics
Professor of Biostatistics
Lev Prasov Lev Prasov
Assistant Professor of Ophthalmology and Visual Sciences
Assistant Professor of Human Genetics
Rajesh-C.-Rao,-M.D..jpg Rajesh Rao
Leonard G Miller Professor of Ophthalmology and Visual Sciences
Associate Professor of Ophthalmology and Visual Sciences
Associate Professor of Pathology
Associate Professor of Human Genetics
JoAnn Sekiguchi JoAnn M Sekiguchi
Associate Professor of Internal Medicine
Associate Professor of Human Genetics
Associate Chair, Department of Human Genetics and Program Director, Human Genetics
Jordan Shavit, MD, PhD Jordan Shavit
Henry and Mala Dorfman Family Professor of Pediatric Hematology/Oncology
Professor of Pediatrics
Professor of Human Genetics
profile-peter-todd-2014 Peter K Todd, MD, PhD
Chester and Anne Alecks Sackett Endowed Professor
Professor of Neurology
Associate Chair for Research
Department of Neurology
Medical Director
Neurology and Professor of Human Genetics
HmGenFcltyHdsGrps21(045) Thomas E Wilson, MD, PhD
Professor of Pathology
Professor of Human Genetics
Associate Medical Director, Molecular Diagnostics Laboratory
Program Assistant
MGP Fellowship Director