Assistant Professor of Biological Chemistry
[email protected]
Available to mentor
Yan Zhang
Assistant Professor
The overarching goal of my lab is (i) to decipher the fascinating biology of diverse CRISPR-Cas systems in bacteria, and (ii) to convert their novel features into new biotechnologies and gene therapy strategies for treating human diseases. We use a multidisciplinary approach blending cell biology, genetics, biochemistry, next-generation sequencing, bioinformatics, and animal models to uncover brand-new CRISPR systems from nature, invent gene-editing tools, and leverage CRISPR therapeutics to tackle a wide range of genetic disorders.
https://yanzhanglab.med.umich.edu/
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Geslewitz WE, Cardenas A, Zhou X, Zhang Y, Criss AK, Seifert HS. mBio, 2024 Feb 14; 15 (2): e0302523Journal ArticleDevelopment and implementation of a Type I-C CRISPR-based programmable repression system for Neisseria gonorrhoeae.
DOI:10.1128/mbio.03025-23 PMID: 38126782 -
Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Nam KH, Zhang Y, Ke A. Mol Cell, 2024 Feb 1; 84 (3): 463 - 475.e5.Journal ArticleExploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
DOI:10.1016/j.molcel.2023.12.034 PMID: 38242128 -
Hou Z, Tan R, Zhang Y. Trends Biochem Sci, 2023 Jan; 48 (1): 9 - 10.Journal ArticleSnapshots of a tiny ancestral nuclease of Cas9.
DOI:10.1016/j.tibs.2022.08.008 PMID: 36100522 -
Tan R, Krueger RK, Gramelspacher MJ, Zhou X, Xiao Y, Ke A, Hou Z, Zhang Y. Mol Cell, 2022 Feb 17; 82 (4): 852 - 867.e5.Journal ArticleCas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems.
DOI:10.1016/j.molcel.2021.12.032 PMID: 35051351 -
Hou Z, Hu C, Ke A, Zhang Y. Curr Protoc, 2022 Feb; 2 (2): e361Journal ArticleIntroducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3.
DOI:10.1002/cpz1.361 PMID: 35129865 -
Gramelspacher MJ, Hou Z, Zhang Y. Methods, 2020 Feb 1; 172: 32 - 41.Journal ArticleBiochemical characterization of RNA-guided ribonuclease activities for CRISPR-Cas9 systems.
DOI:10.1016/j.ymeth.2019.06.018 PMID: 31228550 -
Dolan AE, Hou Z, Xiao Y, Gramelspacher MJ, Heo J, Howden SE, Freddolino PL, Ke A, Zhang Y. Mol Cell, 2019 Jun 6; 74 (5): 936 - 950.e5.Journal ArticleIntroducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.
DOI:10.1016/j.molcel.2019.03.014 PMID: 30975459 -
Hou Z, Zhang Y. Science, 2019 Jul 5; 365 (6448): 25 - 26.Journal ArticleInserting DNA with CRISPR.
DOI:10.1126/science.aay2056 PMID: 31273110
Department News
Yan Zhang, PhD, Jeanne Stuckey, PhD, Markus Ruetz, PhD, Michael Cianfrocco, PhD, and Wei Cheng, PhD, have been promoted.
Department News
Assistant Professor Yan Zhang of the Department of Biological Chemistry at U-M Medical School is the recipient of an NSF CAREER award.
Department News
PhD student Mason Myers of the Zhang lab at U-M Medical School is a lead author of "Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications."
Department News
Yan Zhang lab receives Research Scouts Award for collaborative project
