Ursula H Jakob

 headshot of Ursula Jakob
Patricia S Yaeger Collegiate Professor of Molecular, Cellular and Developmental Biology
Professor of Molecular, Cellular and Developmental Biology
College of Literature, Science, and the Arts
Professor of Biological Chemistry
Medical School
[email protected]
Available to mentor
Ursula H Jakob
headshot of Ursula Jakob
Professor
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    • Recent Publications

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    • Journal Article
      Polyphosphate modulates the stress-responsive formation of functional RNA-protein condensates in bacteria and mammalian cells
      Guan J, Hurto RL, Rai A, Bhattrai J, Azaldegui CA, Ortiz-Rodríguez LA, Liu Q, Biteen JS, Freddolino L, Jakob U. Plos Biology, 2026 Apr 1; 24 (4): e3003775 DOI:10.1371/journal.pbio.3003775
      PMID: 42044170
    • Journal Article
      Checking in on proteostasis
      Sakata E, Hegde RS, Zhao YG, Ito T, Radford SE, Hatzgolou M, Jakob U, Park E, Lin Y, Deuerling E, Yang P, Choe YJ. Nature Structural and Molecular Biology, 2026 Mar 1; 33 (3): 367 - 371. DOI:10.1038/s41594-026-01772-0
      PMID: 41826759
    • Journal Article
      Polyphosphate: a cellular Swiss army knife
      Rai A, Jakob U. Current Opinion in Biotechnology, 2025 Jun 1; 93: DOI:10.1016/j.copbio.2025.103303
      PMID: 40222262
    • Journal Article
      Cryosectioning and immunofluorescence of C. elegans reveals endogenous polyphosphate in intestinal endo-lysosomal organelles
      Quarles E, Petreanu L, Narain A, Jain A, Rai A, Wang J, Oleson B, Jakob U. Cell Reports Methods, 2024 Oct 21; 4 (10): DOI:10.1016/j.crmeth.2024.100879
      PMID: 39413779
    • Journal Article
      Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils
      Huettemann P, Mahadevan P, Lempart J, Tse E, Dehury B, Edwards BFP, Southworth DR, Sahoo BR, Jakob U. Plos Biology, 2024 Oct 1; 22 (10): DOI:10.1371/journal.pbio.3002650
      PMID: 39480879
    • Journal Article
      Author Correction: Fundamentals of redox regulation in biology (Nature Reviews Molecular Cell Biology, (2024), 25, 9, (701-719), 10.1038/s41580-024-00730-2)
      Sies H, Mailloux RJ, Jakob U. Nature Reviews Molecular Cell Biology, 2024 Sep 1; 25 (9): 758 DOI:10.1038/s41580-024-00754-8
      PMID: 38886589
    • Journal Article
      Cellular oxidants and the proteostasis network: balance between activation and destruction
      Ulfig A, Jakob U. Trends in Biochemical Sciences, 2024 Sep 1; 49 (9): 761 - 774. DOI:10.1016/j.tibs.2024.07.001
      PMID: 39168791
    • Journal Article
      Fundamentals of redox regulation in biology
      Sies H, Mailloux RJ, Jakob U. Nature Reviews Molecular Cell Biology, 2024 Sep 1; 25 (9): 701 - 719. DOI:10.1038/s41580-024-00730-2
      PMID: 38689066