Available to mentor
The Giessen Lab is interested in the structure, function, and engineering of protein organelles, protein machines, and enzyme filaments. Our current focus lies on microbial protein organelles, compartments, and filaments involved in detoxification, nutrient utilization, and natural product biosynthesis, as well as on the discovery and characterization of novel enzyme machines and assemblies involved in the biosynthesis of bioactive compounds. We endeavor to leverage our molecular level insights into large protein assemblies for synthetic biology applications in drug delivery, biocatalysis, and bionanotechnology. Our interdisciplinary work utilizes techniques and approaches spanning the fields of biochemistry, structural biology (cryo-EM and x-ray crystallography), microbiology and synthetic biology.
Giessen Lab Website Tobias W. Giessen - Google Scholar
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Postdoctoral Research FellowHarvard Medical School, Systems Biology, 2018
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Postdoctoral Research FellowWyss Institute for Biologically Inspired Engineering at Harvard, Synthetic Biology, 2018
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Postdoctoral Research FellowLoewe Center for Synthetic Microbiology, Marburg, 2014
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PhD in BiochemistryPhilipps-University Marburg, Marburg, 2013
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Diplom (BS/MS) in ChemistryPhilipps-University Marburg, Marburg, 2010
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Benisch R, Giessen TW. 2024 Mar 5;PreprintStructural and biochemical characterization of an encapsulin-associated rhodanese from Acinetobacter baumannii.
DOI:10.1101/2024.02.19.581022 PMID: 38464153 -
Giessen T, Kwon S.PatentProtein-based bacterial nanocompartments
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Benisch R, Andreas MP, Giessen TW. Sci Adv, 2024 Feb 2; 10 (5): eadk9345Journal ArticleA widespread bacterial protein compartment sequesters and stores elemental sulfur.
DOI:10.1126/sciadv.adk9345 PMID: 38306423 -
Szyszka TN, Andreas MP, Lie F, Miller LM, Adamson LSR, Fatehi F, Twarock R, Draper BE, Jarrold MF, Giessen TW, Lau YH. 2024 Feb 6;PreprintPoint mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.
DOI:10.1101/2024.02.05.579038 PMID: 38370832 -
Badieyan S, Andreas MP, Shi J, Aiken C, Giessen TW, Cianfrocco MA. Biophysical Journal, 2024 Feb; 123 (3): 125aJournal ArticleA team of dynein motor proteins drives microtubule-based trafficking of HIV-1
DOI:10.1016/j.bpj.2023.11.860 -
Badieyan S, Lichon D, Andreas MP, Gillies JP, Peng W, Shi J, DeSantis ME, Aiken CR, Böcking T, Giessen TW, Campbell EM, Cianfrocco MA. 2023 Dec 2;PreprintHIV-1 binds dynein directly to hijack microtubule transport machinery.
DOI:10.1101/2023.08.29.555335 PMID: 37693451 -
Kwon S, Andreas MP, Giessen TW. J Struct Biol, 2023 Dec; 215 (4): 108022Journal ArticleStructure and heterogeneity of a highly cargo-loaded encapsulin shell.
DOI:10.1016/j.jsb.2023.108022 PMID: 37657675 -
Andreas MP, Giessen TW. 2023 Sep 25;PreprintCyclodipeptide oxidase is an enzyme filament.
DOI:10.1101/2023.09.25.559410 PMID: 37808672