Thanh Hoang, PhD
Assistant Professor of Ophthalmology and Visual Sciences
Assistant Professor of Cell and Developmental Biology
Medical School
The University of Michigan
1000 Wall Street
Ann Arbor, MI 48105
[email protected]
1000 Wall Street
Ann Arbor, MI 48105
Available to mentor
Thanh Hoang, PhD
Assistant Professor
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Qualifications
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Postdoctoral FellowJohns Hopkins University, Neuroscience, Baltimore, United States
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PhD, NeuroscienceMiami University, Oxford, Ohio, United States
2012 - 2016
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MSc, NeuroscienceUniversity of Tasmania, Neuroscience, Hobart, Australia
2010 - 2012
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BS (Hons), BiotechnologyUniversity of Tasmania, Hobart, Australia
2006 - 2010
Research Overview
The central nervous system (CNS) is a highly complex structure composed of diverse subtypes of neurons and glia. Neurons in the retina, like elsewhere in the CNS, are highly susceptible to diseases, and their loss often result in blindness. Our research focuses on studying cell type specification during neural development and regeneration of lost neurons via cell fate reprogramming as a potential therapy for neurodegenerative diseases. Using a combination of multiomic and genetic tools, We are particularly interested in exploring the regenerative capacity and neuroprotective roles of glial cells: retinal Müller glia and astrocytes, in injury and neurodegenerative disorders.https://hoanglabregen.com/
Links
Hoang Lab
Recent Publications
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Bernstein SL, Mehrabian Z, Guo Y, Jouffroy J, Mead B, Tomarev S, Durmaz E, Epstein JA, Kronk A, Blackshaw S, Hoang T. Proceedings of the National Academy of Sciences of the United States of America, 2026 May 5; 123 (18):Journal ArticleHopx(+) optic nerve head-astrocytes counter neuronal stress and glaucoma damage
DOI:10.1073/pnas.2515277123 -
Singh KK, Jin Y, Hu MW, Palazzo I, Cano M, Hoang T, Bhutto I, Wang S, Sinha D, Blackshaw S, Qian J, Handa JT. Proceedings of the National Academy of Sciences of the United States of America, 2026 Jan 20; 123 (3):Journal ArticleMolecular underpinnings of induced degenerative heterogeneity in the retinal pigment epithelium
DOI:10.1073/pnas.2505412123 PMID: 41543898 -
Appel H, Carmen-Orozco RP, Santiago CP, Hoang T, Blackshaw S. bioRxiv, 2025 Sep 29;Journal ArticlePtbp1 is not required for retinal neurogenesis and cell fate specification.
DOI:10.1101/2025.07.02.662808 PMID: PMC12236599 -
Le N, Awad S, Palazzo I, Hoang T, Blackshaw S. Elife, 2025 May 19; 14:Journal ArticleViral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia.
DOI:10.7554/eLife.106450 PMID: PMC12088672 -
Hoang T. 2025 Aug 7;PresentationThe association for research in Vision and Ophthalmology (ARVO)
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Hoang T. 2025 Jul 29;PresentationInvited Presentation Department of Biology
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Emmerich K, Hageter J, Hoang T, Lyu P, Sharrock AV, Ceisel A, Thierer J, Chunawala Z, Nimmagadda S, Palazzo I, Matthews F, Zhang L, White DT, Rodriguez C, Graziano G, Marcos P, May A, Mulligan T, Reibman B, Saxena MT, Ackerley DF, Qian J, Blackshaw S, Horstick E, Mumm JS. Development, 2024 Aug 1; 151 (15):Journal ArticleA large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.
DOI:10.1242/dev.202754 PMID: PMC11361637 -
Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. Nat Commun, 2024 Jul 15; 15 (1): 5943Journal ArticleA combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.
DOI:10.1038/s41467-024-50033-5 PMID: PMC11251169
Featured News & Stories
Department News
New Publication from the Hoang Lab!
"Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina," has been published in Science Advances.
