Sharan Srinivasan, MD, PhD
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About
Dr. Sharan Srinivasan is an Assistant Professor within the Movement Disorders Division in the Department of Neurology at the University of Michigan. He attended Northwestern University for his bachelor's degree and obtained his combined M.D. Ph.D. at the University of Michigan. He then completed his residency in Neurology at the University of Michigan before pursuing a movement disorders fellowship at Mass General Brigham (Harvard). He returned to the University of Michigan in 2022 to continue his clinical and scientific efforts in caring for and treating cerebellar ataxias.
Center Memberships
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Center MemberFrankel Institute for Heart and Brain Health
Research Overview
His clinical and research interests involve the pathophysiology of cerebellar ataxias, particularly hereditary polyglutamine disorders. His passion is in developing novel therapeutics via a multidisciplinary approach, combining strategies from organic chemistry, molecular biology, neuro-circuitry, and emerging genetic technologies. His focus has been on targeting impaired neuronal circuitry within these disorders, amelioration of which has been shown to improve motor symptoms and delay degeneration.
Lab website: srinivasanlab.com
Recent Publications
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He D, Yano S, Li S, Gary A, Mook A, Lu H, Srinivasan S, Todd P, Shakkottai V, Das S. Genetics in Medicine Open, 2026 Mar 7; 4: 104134Journal ArticleP644: Spinocerebellar ataxia type 50: Recurrent p.(Gly389Arg) variant highlights a shared molecular mechanism and expands the clinical spectrum
DOI:10.1016/j.gimo.2026.104134 -
Srinivasan S, Mook A, Rochman M, Yun J, Chen H, Mu W, Wilmot G, Rosenthal L, Uhlmann W. 2025 Aug 28;Journal ArticlePractice Recommendations for Genetic Testing of Ataxias
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Peppel L, Lai R-Y, Rummey C, Opal P, Schmahmann JD, Gomez CM, Paulson H, Zesiewicz TA, Perlman S, Wilmot G, Ying SH, Onyike CU, Bushara KO, Geschwind MD, Figueroa KP, Pulst SM, Subramony SH, Duquette A, Ashizawa T, Hamedani AG, Davis MY, Srinivasan SR, Burns MR, Amokrane N, Moore LR, Shakkottai VG, Rosenthal LS, Kuo S-H, Lin C-YR. J Neuropsychiatry Clin Neurosci, 2025 May 12; appineuropsych20250006Journal ArticleSuicidal Ideation in Spinocerebellar Ataxia.
DOI:10.1176/appi.neuropsych.20250006 PMID: 40350965 -
Soto I, Bonomo M, Nelthrope B, Sierra M, Paulson H, Shorrock H, Srinivasan S. 2025 May 27;Proceeding / Abstract / PosterImproving Neuronal Function as Treatment for Spinocerebellar Ataxias (SCAs)
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Bonomo M, Soto I, Guo A, Paulson H, Srinivasan S. 2024 Nov 27;Proceeding / Abstract / PosterCircuit Modulation as a Pharmacomimetic of Cardiovascular Exercise in Spinocerebellar Ataxia
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Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. Neurology, 2024 Apr 11; 102 (7_supplement_1):Journal ArticleDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic (P7-3.017)
DOI:10.1212/wnl.0000000000205545 -
Albertson R, Paulson H, Srinivasan S, Shakkottai V, Todd P. 2024 Apr 17;Proceeding / Abstract / PosterDiagnostic Yield of Genetic Testing Over Five Years in a Tertiary Ataxia Clinic
DOI:10.1212/WNL.0000000000205545 -
Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills AM, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V. Cerebellum, 2024 Feb 1; 23 (1): 31 - 51.Journal ArticleClinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping
DOI:10.1007/s12311-022-01471-8 PMID: 36190676
