Roman Giger, PhD
Dr Richard Mark Newman Research Professor of Cell and Developmental Biology
Professor of Cell and Developmental Biology
Professor of Neurology
[email protected]

Available to mentor
Roman Giger, PhD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • PhD
      University of Zurich, Zurich, 1995
    • MS
      University of Zurich, Zurich, 1991
    • BS
      University of Zurich, Zurich, 1990
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Biosciences Initiative
    Research Overview

    Nervous system regeneration, sciatic nerve, optic nerve, axon growth, neuroinflammation, axon-glia interaction, myelination, mouse genetics

    Links
    • Giger Lab
    Recent Publications See All Publications
    • Journal Article
      Structure and function of Semaphorin-5A glycosaminoglycan interactions.
      Nagy GN, Zhao X-F, Karlsson R, Wang K, Duman R, Harlos K, El Omari K, Wagner A, Clausen H, Miller RL, Giger RJ, Jones EY. Nat Commun, 2024 Mar 28; 15 (1): 2723 DOI:10.1038/s41467-024-46725-7
      PMID: 38548715
    • Preprint
      Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.
      Hoard TM, Liu K, Cadigan KM, Giger RJ, Allen BL. 2024 May 29; DOI:10.1101/2024.05.29.596372
      PMID: 38854152
    • Preprint
      Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
      Schmitd LB, Hafner H, Ward A, Asghari Adib E, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao X-F, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ. 2024 Apr 17; DOI:10.1101/2024.03.04.583374
      PMID: 38496662
    • Journal Article
      Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration.
      Passino R, Finneran MC, Hafner H, Feng Q, Huffman LD, Zhao X-F, Johnson CN, Kawaguchi R, Oses-Prieto JA, Burlingame AL, Geschwind DH, Benowitz LI, Giger RJ. Cell Rep, 2024 Mar 26; 43 (3): 113931 DOI:10.1016/j.celrep.2024.113931
      PMID: 38492223
    • Journal Article
      Abstract 1390 Repair Schwann Cell Reprogramming After Peripheral Nerve Injury
      Vitale S, Giger R, Schmitd LB, Haffner H. Journal of Biological Chemistry, 2024 Mar; 300 (3): 106740 DOI:10.1016/j.jbc.2024.106740
    • Journal Article
      DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses.
      Asghari Adib E, Shadrach JL, Reilly-Jankowiak L, Dwivedi MK, Rogers AE, Shahzad S, Passino R, Giger RJ, Pierchala BA, Collins CA. Cell Rep, 2024 Feb 27; 43 (2): 113801 DOI:10.1016/j.celrep.2024.113801
      PMID: 38363678
    • Preprint
      Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature
      Childs C, Poling H, Chen K, Tsai Y-H, Wu A, Sweet C, Vallie A, Eiken M, Huang S, Schreiner R, Xiao Z, Conchola A, Anderman M, Holloway E, Singh A, Giger R, Mahe M, Walton K, Loebel C, Helmrath M, Rafii S, Spence J. 2023 bioRxiv, DOI:10.1101/2023.11.06.565830
    • Journal Article
      Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse.
      Doherty R, MacLeod BL, Nelson MM, Ibrahim MMH, Borges BC, Jaradat NW, Finneran MC, Giger RJ, Corfas G. Sci Rep, 2022 Oct 14; 12 (1): 17267 DOI:10.1038/s41598-022-21598-2
      PMID: 36241655
    Featured News & Stories
    Department News
    April 25, 2024 New Publication from the Giger Lab!
    "Structure and function of Semaphorin-5A glycosaminoglycan interactions," has been published in Nature Communications.