Robert T Kennedy
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About
Robert Kennedy is a Professor of Chemistry and Pharmacology. His research interests are in bioanalytical chemistry with an emphasis on microfluidics, mass spectrometry, chromatography, and electrophoresis. He develops these methods to study neurotransmitter dynamics in vivo, hormone secretion, and for high-throughput experimentation.
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My Background
Qualifications
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PhDUniversity of North Carolina-Chapel Hill, United States
1984 - 1988
Center Memberships
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Center MemberCaswell Diabetes Institute
Research Overview
We develop and apply bioanalytical methods for studying hormone and neurtransmitter secretion. We develop microfluidic chips to culture cells and integrate methods to measure releasate. We also coupling sampling probes to analytical methods for in vivo brain chemical measurements. We develop metabolomics methods for studying biological systems. We have focused LC-MS/MS, capillary electrophoresis, and sensors for analysis. We have applied to study of islets of Langerhans and various rodent models in the brain.
Recent Publications
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Murray BE, Diehl RC, Pott M, Holland-Moritz DA, Narayan ARH, Kennedy RT. Analyst, 2026 Mar 16;Journal ArticleUtilizing Venturi effect for automated high-throughput droplet-MS from well plates.
DOI:10.1039/d6an00065g PMID: PMC12990301 -
Snyder RT, Wortman AK, Xin Y, Penabad LI, Rich LC, Schindler CS, Kennedy RT, Stephenson CRJ. Journal of Chemical Education, 2026 Feb 20;Journal ArticleA 3‑D Printed Millifluidic Reactor for Continuous Flow Photocatalysis in the Teaching Laboratory
DOI:10.1021/acs.jchemed.5c01125 -
Glynos NG, Huels ER, Groenhout T, Raghu A, Nelson A, Kim Y, Zeid AM, Liu T, Mashour GA, Kennedy RT, Pal D. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2026 Feb 4; 46 (5):Journal ArticleNeurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
DOI:10.1523/JNEUROSCI.0742-24.2025 PMID: 41419333 -
Murray BE, Pott M, Beekwilder J, Kennedy RT. Analytical Methods, 2026 Jan 1;Journal ArticleRapid analysis of terpenes produced by fermentation using flow injection analysis coupled to APCI MS
DOI:10.1039/d5ay02027a -
White T, Bain I, Cain CN, Popov P, Evans CR, Kennedy RT. ACS Measurement Science Au, 2025 Dec 17; 5 (6): 879 - 889.Journal ArticleSampling Probes Microfabricated from Parylene-C for In Vivo Neurochemical Monitoring
DOI:10.1021/acsmeasuresciau.5c00102 -
Cain CN, Ma C-H, Popov P, Kennedy RT. Anal Chem, 2025 Dec 9; 97 (48): 26439 - 26448.Journal ArticleImproving the Detection of Analyte Degeneracies in Untargeted Liquid Chromatography-Tandem Mass Spectrometry Data.
DOI:10.1021/acs.analchem.5c03704 PMID: PMC12961633 -
Mavrakis E, Knecht GT, Unger MJ, Narayan ARH, Kennedy RT. Analytical Chemistry, 2025 Dec 9; 97 (48): 26607 - 26615.Journal ArticlePhenotyping and Selection of Cells Using Mass Spectrometry and a Microfluidic Droplet Printer
DOI:10.1021/acs.analchem.5c05032 -
Hershey ND, Popov P, Oliver N, Dugan CE, Kennedy RT. ACS Chemical Neuroscience, 2025 Sep 3; 16 (17): 3398 - 3409.Journal ArticleDetection of Neuronal Glutamate in Brain Extracellular Space In Vivo Using Microdialysis and Metabolic Labeling with Glutamine
DOI:10.1021/acschemneuro.5c00518 PMID: 40838767