Associate Chair, Clinical Research
Associate Professor of Radiation Oncology
Radiation Oncology
1500 E Medical Center Dr
Ann Arbor, MI 48109
[email protected]
1500 E Medical Center Dr
Ann Arbor, MI 48109
Available to mentor
Michelle Mierzwa, MD
Clinical Associate Professor
Dr. Mierzwa has 13 years of clinical experience in treatment of head and neck cancer. Her clinical research interests have included novel chemoradiation regimens for head and neck cancers, as well as imaging markers and biomarkers of tumor response to radiation and toxicity. Specifically, she collaborates with the Departments of Otolaryngology and Medical Oncology to develop clinical trials to identify for oropharynx cancer patients who may be eligible for de-escalation of chemoradiation or may require intensified therapy. She is also the PI of an ongoing novel oropharynx cancer surveillance and survivorship protocol.
RadOnc Bio
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ResidencyUniversity of Cincinnati, Division of Radiology, 2008
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InternshipChrist Hospital, Internal Medicine, 2004
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MDUniversity of Cincinnati - College of Medicine, 231 Albert Sabin Way, 2003
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MSVanderbilt Universtiy, 2201 West End Ave, 1999
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BSVanderbilt University, Nashville, 1997
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Center MemberRogel Cancer Center
- Advanced imaging techniques and imaging markers of response to radiotherapy in head and neck cancer
- Development of prognostic and predictive biomarkers in head and neck cancer
- Outcome modelling for tumor control and toxicity in head and neck cancer treated with radiotherapy Clinical trial development to de-escalate radiotherapy in oropharynx cancer
- Clinical trial development using imaging markers to improve tumor control in high-risk head and neck cancer treated with radiotherapy
- Head and neck cancer
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Hochfelder C, Walline H, Bhambhani C, Brummel C, Sandford E, Akhdar R, Casper K, Chinn SB, Heft-Neal ME, Malloy K, Shah JL, Shuman A, Spector M, Stucken CL, Worden F, Prince ME, Mierzwa ML, Swiecicki PL, Tewari M, Brenner C. International Journal of Radiation Oncology • Biology • Physics, 2024 Apr; 118 (5): e62 - e63.Journal ArticleCLIA Validation of a New High Performance HPV ctDNA Assay Covering Multiple High Risk HPV Types
DOI:10.1016/j.ijrobp.2024.01.139 -
Gharzai LA, Morris E, Nguyen-Tan PF, Rosenthal DI, Gillison M, Harari PM, Garden AS, Zanotti K, Caudell JJ, Jones CU, Mitchell DL, Krempl GA, Ridge JA, Gensheimer MF, Bonner JA, Le QT, Torres-Saavedra P, Mierzwa ML, Schipper M. International Journal of Radiation Oncology • Biology • Physics, 2024 Apr; 118 (5): e14Journal ArticleSurrogate Endpoints in p16-Positive Squamous Cell Carcinoma of the Oropharynx
DOI:10.1016/j.ijrobp.2024.01.035 -
Swiecicki PL, Bellile E, Dragovic AF, McHugh J, Udager A, Mierzwa ML, Shah J, Heft Neal M, Rosko A, Malloy KM, Casper K, Chinn SB, Shuman AG, Stucken C, Chepeha DB, Wolf GT, Bradford CR, Eisbruch A, Prince MEP, Worden FP, Spector ME. Clin Cancer Res, 2024 Mar 22;Journal ArticleUpfront neck dissection for treatment selection and improvement in quality of life as a novel treatment paradigm for deintensification in HPV+ OPSCC.
DOI:10.1158/1078-0432.CCR-23-3247 PMID: 38517480 -
Cao Y, Davarani SN, You D, Feiweier T, Casper K, Balis U, Udager A, Balter J, Mierzwa M. J Magn Reson Imaging, 2024 Mar; 59 (3): 929 - 938.Journal ArticleIn Vivo Microstructure Imaging in Oropharyngeal Squamous Cell Carcinoma Using the Random Walk With Barriers Model.
DOI:10.1002/jmri.28831 PMID: 37366349 -
Gharzai LA, Morris E, Suresh K, Nguyen-Tân PF, Rosenthal DI, Gillison ML, Harari PM, Garden AS, Koyfman S, Caudell JJ, Jones CU, Mitchell DL, Krempl G, Ridge JA, Gensheimer MF, Bonner JA, Filion E, Dunlap NE, Stokes WA, Le Q-T, Torres-Saavedra P, Mierzwa M, Schipper MJ. Lancet Oncol, 2024 Mar; 25 (3): 366 - 375.Journal ArticleSurrogate endpoints in clinical trials of p16-positive squamous cell carcinoma of the oropharynx: an individual patient data meta-analysis.
DOI:10.1016/S1470-2045(24)00016-0 PMID: 38423050 -
Bhambhani C, Kang Q, Hovelson DH, Sandford E, Olesnavich M, Dermody SM, Wolfgang J, Tuck KL, Brummel C, Bhangale AD, He K, Gutierrez MG, Lindstrom RH, Liu C-J, Tuck M, Kandarpa M, Mierzwa M, Casper K, Prince ME, Krauss JC, Talpaz M, Henry NL, Giraldez MD, Ramnath N, Tomlins SA, Swiecicki PL, Brenner JC, Tewari M. JCI Insight, 2024 Feb 8; 9 (6):Journal ArticlectDNA transiting into urine is ultrashort and facilitates noninvasive liquid biopsy of HPV+ oropharyngeal cancer.
DOI:10.1172/jci.insight.177759 PMID: 38516891 -
Mayo CS, Feng MU, Brock KK, Kudner R, Balter P, Buchsbaum JC, Caissie A, Covington E, Daugherty EC, Dekker AL, Fuller CD, Hallstrom AL, Hong DS, Hong JC, Kamran SC, Katsoulakis E, Kildea J, Krauze AV, Kruse JJ, McNutt T, Mierzwa M, Moreno A, Palta JR, Popple R, Purdie TG, Richardson S, Sharp GC, Satomi S, Tarbox LR, Venkatesan AM, Witztum A, Woods KE, Yao Y, Farahani K, Aneja S, Gabriel PE, Hadjiiski L, Ruan D, Siewerdsen JH, Bratt S, Casagni M, Chen S, Christodouleas JC, DiDonato A, Hayman J, Kapoor R, Kravitz S, Sebastian S, Von Siebenthal M, Bosch W, Hurkmans C, Yom SS, Xiao Y. Int J Radiat Oncol Biol Phys, 2023 Nov 1; 117 (3): 533 - 550.Journal ArticleOperational Ontology for Oncology (O3): A Professional Society-Based, Multistakeholder, Consensus-Driven Informatics Standard Supporting Clinical and Research Use of Real-World Data From Patients Treated for Cancer.
DOI:10.1016/j.ijrobp.2023.05.033 PMID: 37244628 -
Gharzai LA, Mierzwa ML, Peipert JD, Kirtane K, Casper K, Yadav P, Rothrock N, Cella D, Shaunfield S. JAMA Otolaryngol Head Neck Surg, 2023 Oct 1; 149 (10): 884 - 890.Journal ArticleMonitoring Adverse Effects of Radiation Therapy in Patients With Head and Neck Cancer: The FACT-HN-RAD Patient-Reported Outcome Measure.
DOI:10.1001/jamaoto.2023.2177 PMID: 37589994
