Leslie Satin

portrait of Leslie Satin
Joanne I Moore Research Professor of Pharmacology
Professor of Pharmacology and Professor of Internal Medicine
Medical School
University of Michigan Medical School
Pharmacology
Brehm Tower 5128, Kellogg Eye Center, 1000 Wall St.
Ann Arbor, MI 48105
[email protected]
Available to mentor
Leslie Satin
portrait of Leslie Satin
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Dr. Les Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology and also an investigator in the Brehm Diabetes Research Center and the Caswell Diabetes Institute. He is an affiliate professor of MEND, in Internal Medicine. He trained at UCLA, SUNY Stony Brook, and the University of Washington, Seattle, where he was in the Department of Physiology and Biophysics of the UW Medical School and a fellow in Metabolism and Endocrinology at the Seattle Veterans Affairs Medical Center. Dr. Satin was trained in the areas of membrane biophysics, neurobiology, electrophysiology and ion channels. He has been on the faculty at UM since 2008. In 2016, Dr. Satin was visiting professor at the University of Uppsala in Uppsala, Sweden with Drs. Anders Tengholm and Sebastian Barg in the Department of Medical Cell Biology.

    Qualifications

    • fellow
      University of Washington, Seattle, Physiology and Biophysics, Seattle, United States
      1984 - 1990
      Postdoctoral Research
    • postdoctoral fellow
      SUNY Stony Brook, Neurobiology and Behavior, Stony Brook NY, United States
      1982 - 1984
      Postdoctoral Fellowship

    Center Memberships

    • Center Member
      Weil Institute for Critical Care Research
    • Center Member
      Caswell Diabetes Institute

    Research Overview

    Pancreatic islets, beta cell stimulus secretion coupling, beta cell biology, oscillations in biological systems, calcium signaling in organelles and cytosol, mathematical modeling, genetically encoded sensors, live cell imaging.

    Recent Publications

    See All Publications
    • Journal Article
      Subcellular Compartmentalization of Glucose Mediated Insulin Secretion
      Wang Z, Gurlo T, Satin LS, Fraser SE, Butler PC. Cells, 2025 Feb 1; 14 (3): DOI:10.3390/cells14030198
      PMID: 39936989
    • Proceeding / Abstract / Poster
      The Mechanisms of Pulsatile Basal Insulin Secretion
      Liu C, Fletcher PA, Marinelli I, Bertram R, Satin LS, Sherman AS. 2024 Jul 27;
    • Proceeding / Abstract / Poster
      The Mechanisms of Pulsatile Basal Insulin Secretion
      Liu C, Fletcher PA, Marinelli I, Bertram R, Satin LS, Sherman AS. 2024 Jul 27;
    • Journal Article
      Do We Need a New Hypothesis for KATP Closure in b-Cells? Distinguishing the Baby From the Bathwater
      Satin LS, Corradi J, Sherman AS. Diabetes, 2024 Jun 1; 73 (6): 844 - 848. DOI:10.2337/db24-0131
      PMID: 38640066
    • Journal Article
      Proinsulin Folding and Trafficking Defects Trigger a Common Pathological Disturbance of Endoplasmic Reticulum Homeostasis
      Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour S, Satin L, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman R, Liu M, Arvan P. Protein Science, 2024 Mar 3; 33 (4): DOI:10.1002/pro.4949
    • Presentation
      Oscillatory Metabolism and Insulin Secretion
      Satin LS. 2025 Apr 28;
    • Proceeding / Abstract / Poster
      Amino acids modulate beta cell KATP activity via the PEP cycle and OXPHOS
      Corradi J, Satin LS. 2024 Apr 26;
    • Proceeding / Abstract / Poster
      Amino acids modulate beta cell KATP activity via the PEP cycle and OXPHOS
      Corradi J, Satin LS. 2024 Apr 26;

    Featured News & Stories

    Department News

    Dr. Les Satin has book published for IOP Press

    Dr. Les Satin has book published for IOP Press
    Department News

    Les Satin interviewed in March 2023 Biophysical Society Bulletin

    Les Satin, University of Michigan Medical School professor, was interviewed in March 2023 Biophysical Society Bulletin.