Jack M Parent

 Jack M. Parent
Professor
Email:
[email protected]
Available to mentor
Jack M Parent
Jack M. Parent
Professor
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • Qualifications
    • Postdoctoral Fellow, Epilepsy Research Laboratory
      University of California, San Francisco, San Francisco, United States
      1996 - 2000
      Postdoctoral Fellowship
    • Fellow in Epilepsy and Clinical Neurophysiology, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1994 - 1996
      Postdoctoral Fellowship
    • Chief Resident, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1993 - 1994
      Chief Resident
    • Resident, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1991 - 1993
      Residency
    • Intern, Department of Internal Medicine
      University of California, San Francisco, San Francisco, United States
      1990 - 1991
      Internship
    • MD
      Yale University School of Medicine, New Haven, CT, United States
      1986 - 1990
    • AB
      Stanford University, Stanford, CA, United States
      1982 - 1986

    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Taubman Institute

    Recent Publications

     See All Publications
    • Journal Article
      Genome-wide CRISPRi screen in human iNeurons identifies novel negative mTOR regulator genes associated with focal cortical dysplasia
      Tidball AM, Luo J, Walker JC, Takla TN, Carvill GL, Parent JM. Neurobiology of Disease, 2026 Oct 15; 229: DOI:10.1016/j.nbd.2026.107602
      PMID: 42731765
    • Journal Article
      SCN1B intron 3 retention results in a nonsense-mediated decay sensitive mRNA linked to developmental and epileptic encephalopathy
      Bakshi S, Catalfio AM, Chen C, Moore C, Verma I, Minton J, Dang L, El Achkar CM, Poduri A, Parent JM, Isom LL. Proceedings of the National Academy of Sciences of the United States of America, 2026 Apr 30;
    • Journal Article
      Gene-specific machine learning model EpiPred identifies likely pathogenic variants in the epilepsy-related gene STXBP1.
      Calhoun JD, Wang C, Biar CG, Gunti JR, Lee JS, Geller AM, Hong JH, Schnell S, Dang LT, Wang Y, Parent JM, Isom LL, Uhler MD, Mefford HC, Ross ME, Aguiar-Pulido V, Carvill GL. J Clin Invest, 2026 Sep 17; DOI:10.1172/JCI207160
      PMID: 42752354
    • Journal Article
      Cryopreservation of human cortical organoids using vitrification
      Stokes K, Mojica-Perez S, Jacobs S, Huang J, Vaid S, Yuan Y, Pearson CA, Montes D, Tidball A, VanHeyningen D, Gaillard J, Dang LT, Ross ME, Isom LL, Uhler M, Niu W, Parent JM. Frontiers in Molecular Neuroscience, 2026 Sep 18; 19: 1913908 - 1913908. DOI:10.3389/fnmol.2026.1913908
    • Journal Article
      Thalamic NRXN1-mediated input to human cortical progenitors drives excitatory neurogenesis
      Nguyen CV, Martija A, Jaklic DC, White R, Yang MG, Nano PR, Soto JA, Mil J, Rana D, Martin JM, Schweiger HE, Hernandez S, Fazzari E, Liu Y, Parent JM, Mostajo-Radji MA, Geschwind DH, Bhaduri A. Science New York N Y, 2026 Sep 3; 393 (6815): eady5180 DOI:10.1126/science.ady5180
      PMID: 42691176
    • Journal Article
      Modeling Epilepsies with Human Brain Organoids: Recent Advances and Ongoing Challenges
      Walker MP, Parent JM. Epilepsy Currents, 2026 Sep 1; 26 (5): 406 - 414. DOI:10.1177/15357597261469411
    • Journal Article
      Navigating Human Astrocyte Differentiation: Direct and Rapid One-Step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network Development
      Schuurmans IME, Mordelt A, Guevara-Ferrer M, Linda K, Duineveld D, Puvogel S, Hommersom MP, Scheefhals N, Rahm L, Dyke E, Scholten GJ, Knorz C, Jimenez CG, van Egmond N, Oudakker A, Bijnagte-Schoenmaker C, van Bokhoven H, Wei W, Hofmann S, Jung-Klawitter S, Mojica-Perez S, Parent J, Carotenuto L, Weckhuysen S, Maas N, Elgersma Y, van de Ven E, Lefeber D, Lygeroudi A, de Vries HE, Jordi L, Polymenidou M, Mitchell-Garcia T, Dragan I, Dolga A, de Witte LD, van Karnebeek CDM, Ellis J, Garanto A, Nadif Kasri N. GLIA, 2026 Sep 1; 74 (9): DOI:10.1002/glia.70202
      PMID: 42452972
    • Preprint
      A CK2α–G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS
      Agrawal M, Desai M, Ghumra S, Bhorkar Y, Vaglio BJ, Stokes K, Rana K, Hill N-ZH, Nweze P, Sriram N, LoRé A, Kawaguchi R, Firestein BL, Parent J, Geschwind DH, Rebholz H, Sahoo PK. 2026 Aug 19; bioRxiv, DOI:10.64898/2026.08.11.744218

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