Henry L Paulson, MD PhD
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About
Dr. Paulson is the Lucile Groff Professor of Neurology in the Department of Neurology at the University of Michigan, where he also serves as Director of the Michigan Alzheimer’s Disease Center. Dr. Paulson received his MD and PhD degrees from Yale University, completed residency and fellowship training at the University of Pennsylvania, and previously taught at the University of Iowa. His research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with an emphasis on repeat expansion diseases and age-related dementias. He is a member of the National Academy of Medicine, an elected fellow of the American Association for the Advancement of Science, and a recipient of the Landis Outstanding Mentor Award from the National Institutes of Health.
Qualifications
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movement disorders and neurogeneticsUniversity of Pennsylvania Health System, Philadelphia, United States
1994 - 1997
Clinical Fellowship
Center Memberships
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Center MemberTaubman Institute
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Paulson's basic and clinical research focuses on age-related neurodegenerative diseases including Alzheimer's and related dementias as well as hereditary movement disorders including the ataxias. He directs the Michigan Alzheimer's Disease Center, which supports a wide range research projects to understand the causes and treatment of cognitive impairment. His laboratory studies the molecular mechanisms of various neurodegenerative diseases, with the goal of identifying therapeutic targets that can lead to treatments for currently fatal disorders.
Recent Publications
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Mahajan A, Dwivedi AK, Galvin JE, Maixner SM, Paulson HL, Manning CA, Fields JA, Boeve BF, Mills KA, Morrow C, Pontone GM, Armstrong MJ. Neurology, 2026 Apr 15; 106 (9):Journal ArticleCognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies
DOI:10.1212/wnl.0000000000214934 -
Dunietz GL, Lyu X, Paulson H, Chervin R, Shedden K, Braley T. Sleep, 2026 May 10; 49 (Supplement_1): a509 - a509.Journal Article1142 Obstructive Sleep Apnea, Use of Positive Airway Pressure Therapy, and Dementia Incidence: A Longitudinal Study of Medicare Beneficiaries
DOI:10.1093/sleep/zsag091.1141 -
Irfan B, Pal S, Reader J, Bakulski KM, Paulson H, Giordani B. Medicine, 2026 Feb 20; 105 (8): e47717Journal ArticleLinking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis
DOI:10.1097/MD.0000000000047717 PMID: 41731796 -
Wang X, Bakulski KM, Walker E, Mukherjee B, Dodge H, Albin RL, Paulson HL, Park SK. Alzheimer S and Dementia, 2026 Feb 1; 22 (2):Journal ArticleExposure to lead and incidence of Alzheimer's disease and all-cause dementia in the United States
DOI:10.1002/alz.71075 -
Walker E, Rodríguez-Carmona Y, Wang X, Mukherjee B, Arboleda-Merino L, Hao W, Dodge H, Albin RL, Paulson HL, Park SK, Bakulski KM. 2026 Jan 21; medRxiv,PreprintCadmium Exposure and Incidence of All-Cause Dementia and Alzheimer’s Disease in US Adults
DOI:10.64898/2026.01.16.26344271 -
Robertson JW, Adanyeguh I, Arpin DJ, Ashizawa T, Bender B, Cendes F, Chen X, Coarelli G, Coutinho L, Deistung A, Dogan I, Durr A, Faber J, Fernandez-Ruiz J, Ferreira M, França MC, Göricke SL, Han S, Klockgether T, Liu C, Luo J, Martinez ARM, Ono SE, Onyike CU, Öz G, Paulson H, Prince JL, Reetz K, Rezende TJR, Synofzik M, Ghizoni Teive HA, Thomopoulos SI, Thompson PM, Timmann D, Vaillancourt D, van de Warrenburg B, van Gaalen J, Wang X, Wegner P, Ying SH, Harding IH, Hernandez-Castillo CR. Movement Disorders, 2026 Jan 1;Journal ArticleA Severity-Agnostic Atrophy Pattern in Spinocerebellar Ataxia Type 3: Volumetrics from ENIGMA-Ataxia
DOI:10.1002/mds.70349 PMID: 42108727 -
Jung Y, Counts SE, Hampstead BM, Peltier SJ, Paulson HL, Giordani B, Bhaumik AK, Beck JS, Damoiseaux JS. Aging Brain, 2026 Mar 6; 9: 100157Journal ArticlePlasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline
DOI:10.1016/j.nbas.2026.100157 -
Rezende TJR, Petit E, Park YW, du Montcel ST, Joers JM, DuBois JM, Arnold HM, Povazan M, Özdemir I, Banan G, Valabregue R, Ehses P, Faber J, Onyike CU, Barker PB, Schmahmann JD, Ratai EM, Subramony SH, Mareci TH, Bushara KO, Paulson H, Klockgether T, Durr A, Ashizawa T, Lenglet C, Öz G. Annals of Clinical and Translational Neurology, 2026 Jan 1;Journal ArticleValue of MRI Outcomes for Preventive and Early-Stage Trials in Spinocerebellar Ataxias 1 and 3
DOI:10.1002/acn3.70325 PMID: 41665609
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