Gilbert S Omenn, MD, PhD

Gilber Omenn
Harold T Shapiro Distinguished University Professor of Medicine
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
Professor of Human Genetics
Medical School and Professor of Environmental Health Sciences
School of Public Health
Email:
[email protected]
Available to mentor
Gilbert S Omenn, MD, PhD
Gilber Omenn
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
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  • About

    Gil Omenn is Harold T. Shapiro Distinguished University Professor of the Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, Internal Medicine, Human Genetics, and Public Health at the University of Michigan, Ann Arbor, USA. He served as Executive Vice President for Medical Affairs and as Chief Executive Officer of the University of Michigan Health System from 1997 to 2002. He was Dean of the School of Public Health, and Professor of Medicine and Environmental Health, University of Washington, Seattle, 1982-1997. He is the leader of the global Human Proteome Project (HPP) of the Human Proteome Organization (HUPO). His current research is focused on proteogenomics of alternative splicing in cancers. Splice variants are a major source of protein diversity in multi-cellular organisms with multi-exonic genes. Splice isoforms are good candidates for more specific biomarkers and therapeutic targets. He is author of 700 publications. Omenn has visited China 12 times since 1976. He is an honorary faculty of Peking Union Medical College, affiliate faculty of the Institute for Systems Biology in Seattle, member of the U.S. National Academy of Medicine, past president of the American Association for the Advancement of Science, board member of the Weizmann Institute of Science in Israel, and a director of several biotech companies. He served as a White House Fellow at the U.S. Atomic Energy Commission and as associate director of the White House Office of Science & Technology Policy and Office of Management & Budget. He earned the B.A. from Princeton University, M.D. from Harvard Medical School, and PhD in genetics from University of Washington. He is a musician and tennis player.

    Center Memberships

    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Institute for Healthcare Policy and Innovation

    Research Overview

    Dr. Omenn's research focuses on proteo-genomics of cancers and proteomics informatics. He long chaired and remains active in the Human Proteome Organization (HUPO) global Human Proteome Project (www.thehpp.org). There are datasets for application of analytical tools, and there are research teams eager to engage in collaborative studies in the Chromosome-centric HPP and Biology and Disease-driven HPP initiatives. He is a co-founder of the Consortium for Clinical Characterization of Covid-19 using Electronic Health Records (4CE) organized by the i2b2tranSMART Foundation and Harvard colleagues. He has long-standing interests in mechanisms of genetic predispositions to risks from environmental and occupational exposures (eco-genetics) and science-based risk analyses.

    Recent Publications

    See All Publications
    • Journal Article
      VO: The Vaccine Ontology
      Zheng J, Lin AY, Huffman A, Masci AM, Racz R, Wu G, Roan K, Ong E, Sarntivijai S, Hu J, Asfaw E, Kahn H, Li X, Zhang X, Monickaraj J, Kosar N, Li J, Manuel W, Abeysinghe R, Rehana H, Bansal B, Pan Y, Guo J, He V, Song J, Seleznev AI, Hur K, He A, Davydov A, Yang Q, Ostropolets A, Vita R, Peters B, Ruttenberg A, Diehl AD, Hoyt CT, Roncaglia P, Huntley RP, Scheuermann RH, Courtot M, Todd T, Sayers S, Chen F, Li X, Yeh FY, Xiang Z, Ozgur A, Whetzel PL, Musen MA, Mungall CJ, Leitner WW, Cui L, Colby LA, Mobley HLT, Athey BD, Omenn GS, Cowell LG, Tao C, Hur J, Smith B, He Y. Scientific Data, 2026 Dec 1; 13 (1): DOI:10.1038/s41597-026-07298-w
      PMID: 42062309
    • Proceeding / Abstract / Poster
      Surrogate Interpretable Models as Explainable Devices for LLMs Used on Unstructured Clinical Text Question & Answering
      Kay A, Mamer L, Schmitzberger F, Janke A, Omenn G, Najarian K. 2026 Oct 29;
    • Journal Article
      Current Standards of Monitoring Models in Healthcare Settings
      Kay A, Takher D, Liu W, Wittrup E, Omenn GS, Najarian K. Advanced Intelligent Discovery, 2026 Sep 13; DOI:10.1002/aidi.70160
    • Journal Article
      Unlocking the Circulating Proteome: Toward Clinical Translation.
      Ahadi S, Babačić H, Cantrell LS, Hornburg D, Müller-Reif JB, Dagley LF, Guerrera IC, Albrecht V, Edfors F, Yu X, Sun Z, Moritz RL, Schmidt F, Hauck SM, Deutsch EW, Omenn GS, Schwenk JM, Geyer PE. J Proteome Res, 2026 Sep 4; 25 (9): 4367 - 4379. DOI:10.1021/acs.jproteome.6c00277
      PMID: 42695895
    • Journal Article
      AI proteomics: from protein identification to virtual cells
      Sun Y, Jun A, Liu Z, Sun R, Qian L, Payne SH, Bittremieux W, Ralser M, Li C, Chen Y, Dong Z, Perez-Riverol Y, Khan A, Sander C, Aebersold R, Vizcaíno JA, Krieger JR, Yao J, Han W, Zhang L, Zhu Y, Xuan Y, Sun BB, Qiao L, Hermjakob H, Tang H, Gao H, Deng Y, Zhong Q, Chang C, Bandeira N, Li M, E W, Sun S, Yang Y, Omenn GS, Zhang Y, Xu P, Fu Y, Liu X, Overall CM, Wang Y, Deutsch EW, Chen L, Cox J, Demichev V, He F, Huang J, Jin H, Liu C, Li N, Luan Z, Song J, Yu K, Wan W, Wang T, Zhang K, Zhang L, Bell PA, Mann M, Zhang B, Guo T. Nature Methods, 2026 Sep 1; 23 (9): 1697 - 1709. DOI:10.1038/s41592-026-03085-y
      PMID: 42521824
    • Journal Article
      Translational bottlenecks in blood-based proteomics
      Ahadi S, Hornburg D, Babačić H, Müller-Reif JB, Cantrell LS, Edfors F, Hauck SM, Deutsch EW, Omenn GS, Geyer PE, Schwenk JM. EMBO Molecular Medicine, 2026 Aug 12; 18 (8): 3011 - 3016. DOI:10.1038/s44321-026-00468-8
      PMID: 42265367
    • Journal Article
      A comprehensive proteogenomic, immunopeptidomic, and metabolomic atlas decodes immunogenicity in cutaneous melanoma
      Cieslik M, Gong J, Petralia F, Cuevas MVR, Tignor N, Jain R, Gritsenko M, Chowdhury S, Kitata RB, Ma W, Hsiao Y, Deng Y, Clauser K, Byrd A, Krek A, Ibing S, Chen L, Song X, Day N, Kim H, Hu Y, Weitz K, Chu R, Lalli P, Schepmoes A, Eder J, Sagendorf T, Petyuk V, Clendinen C, Flores J, Moore R, Monroe M, Hernandez G, Ctortecka C, Verzani E, Lippincott I, Beaumont K, Li Y-C, Marino G, Yu F, Zhang Y, Cruz G, Hosseini N, Shang Y, Clark N, Newton C, Freeman M, Dou Y, Choi S, Aranha M, Edwards N, An E, Zhang X, Robles A, Lazar A, Shi T, Ding L, Zhang B, Mani DR, Omenn G, Gillette M, Carr S, Dhanasekaran S, Mesri M, Thiagarajan M, Nesvizhskii A, Zhang H, Hostetter G, Ma'ayan A, Kyle J, Abelin J, Harms P, Paulovich A, Davar D, Liu T, Wang P. Cancer Discovery, 2026 Jan 29; In Press:
    • Journal Article
      Integrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets
      Chu SCA, Hsiao Y, Wang C, Kyle JE, Jain R, Deng Y, Gritsenko MA, Henry LE, Lei JT, Dou Y, Tercan B, Shi Z, Gondal MN, Tsai CF, Elizarraras JM, Chu RK, Yu F, Joshi SK, Jing X, Polasky DA, Weitz KK, Li GX, Paurus VL, Clendinen CS, Schepmoes AA, Lalli PM, Eder JG, Flores JE, Stratton KG, Pino JC, Posso C, Petyuk VA, Sagendorf TJ, Xu Y, Ibrahim OM, Moore RJ, Zhao R, Chen J, Monroe ME, Thiagarajan M, Hostetter G, Newton C, An E, Robles AI, Zhang X, Edwards NJ, Lu Y, Zhang H, Abdelhakim H, Piehowski PD, Mesri M, Smith RD, Kumar-Sinha C, Tognon CE, Dunlap J, Traer E, Ding L, Tyner JW, Chinnaiyan AM, Omenn GS, Rodland KD, Dhanasekaran SM, Gosline SJC, Nesvizhiskii AI, Zhang B, Liu T, Cieslik MP, Zaalishvili K, Xu Y, Wiznerowicz M, Williams BO, Wang Y, Wang P, Wang C, Vucic M, Venkatachari S, Vatanian N, Tsai CF, Thangudu RR, Garcia-Buntley SS, Shutack Y, Satpathy S, Rudnick P, Rohrer D, Rivero G, Prilutskaya M, Potapova O, Eser PO, Pilozzi A, Pico A, Petralia F, Paulovich AG, Parolia A, Pandey A, Nyce K, Noyama J, McGarvey P, Mays M, Mannan R, Mani DR. Nature Cancer, 2026 Jun 1; 7 (6): 993 - 1015. DOI:10.1038/s43018-026-01175-6
      PMID: 42286338

    Featured News & Stories

    Department News

    Highlighted Publications: January - May 2026

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Aviv Regev and Gilbert S. Omenn
    Department News

    Omenn Lecture explores how AI is transforming medicine

    The Kahn Auditorium was standing room only for the ninth annual Ommen Lecture, this year presented by Aviv Regev, PhD.
    A photo of Aviv Regev, PhD
    Department News

    Mark your calendars: Aviv Regev to give Omenn lecture March 25

    The ninth annual Gilbert S. Omenn Lecture is approaching, with this year’s talk presented by Aviv Regev, PhD titled “From Cell Atlases to Medicines, with AI”
    Gilbert Omenn, M.D., Ph.D.
    Medical School News

    Gil Omenn, M.D., Ph.D. Receives the prestigious AAAS Philip Hauge Abelson Prize

    Gilbert S. Omenn, M.D., Ph.D. is the recipient of the 2026 AAAS Philip Hauge Abelson Prize, which honors an individual who has made significant contributions to the advancement of science in the United States through their research, policy work or public service.
    Department News

    Highlighted Publications - January 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Martha Darling, PhD, and Gilbert Omenn, MD, PhD
    Department News

    Dr. Gilbert S. Omenn and Martha Darling receive honorary Ph.D. degrees from the Weizmann Institute of Science

    Dr. Gilbert S. Omenn and Martha Darling receive honorary Ph.D. degrees from the Weizmann Institute of Science