Gilbert S Omenn, MD, PhD
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About
Gil Omenn is Harold T. Shapiro Distinguished University Professor of the Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, Internal Medicine, Human Genetics, and Public Health at the University of Michigan, Ann Arbor, USA. He served as Executive Vice President for Medical Affairs and as Chief Executive Officer of the University of Michigan Health System from 1997 to 2002. He was Dean of the School of Public Health, and Professor of Medicine and Environmental Health, University of Washington, Seattle, 1982-1997. He is the leader of the global Human Proteome Project (HPP) of the Human Proteome Organization (HUPO). His current research is focused on proteogenomics of alternative splicing in cancers. Splice variants are a major source of protein diversity in multi-cellular organisms with multi-exonic genes. Splice isoforms are good candidates for more specific biomarkers and therapeutic targets. He is author of 700 publications. Omenn has visited China 12 times since 1976. He is an honorary faculty of Peking Union Medical College, affiliate faculty of the Institute for Systems Biology in Seattle, member of the U.S. National Academy of Medicine, past president of the American Association for the Advancement of Science, board member of the Weizmann Institute of Science in Israel, and a director of several biotech companies. He served as a White House Fellow at the U.S. Atomic Energy Commission and as associate director of the White House Office of Science & Technology Policy and Office of Management & Budget. He earned the B.A. from Princeton University, M.D. from Harvard Medical School, and PhD in genetics from University of Washington. He is a musician and tennis player.
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberInstitute for Healthcare Policy and Innovation
Research Overview
Dr. Omenn's research focuses on proteo-genomics of cancers and proteomics informatics. He long chaired and remains active in the Human Proteome Organization (HUPO) global Human Proteome Project (www.thehpp.org). There are datasets for application of analytical tools, and there are research teams eager to engage in collaborative studies in the Chromosome-centric HPP and Biology and Disease-driven HPP initiatives. He is a co-founder of the Consortium for Clinical Characterization of Covid-19 using Electronic Health Records (4CE) organized by the i2b2tranSMART Foundation and Harvard colleagues. He has long-standing interests in mechanisms of genetic predispositions to risks from environmental and occupational exposures (eco-genetics) and science-based risk analyses.
Recent Publications
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Zheng J, Lin AY, Huffman A, Masci AM, Racz R, Wu G, Roan K, Ong E, Sarntivijai S, Hu J, Asfaw E, Kahn H, Li X, Zhang X, Monickaraj J, Kosar N, Li J, Manuel W, Abeysinghe R, Rehana H, Bansal B, Pan Y, Guo J, He V, Song J, Seleznev AI, Hur K, He A, Davydov A, Yang Q, Ostropolets A, Vita R, Peters B, Ruttenberg A, Diehl AD, Hoyt CT, Roncaglia P, Huntley RP, Scheuermann RH, Courtot M, Todd T, Sayers S, Chen F, Li X, Yeh FY, Xiang Z, Ozgur A, Whetzel PL, Musen MA, Mungall CJ, Leitner WW, Cui L, Colby LA, Mobley HLT, Athey BD, Omenn GS, Cowell LG, Tao C, Hur J, Smith B, He Y. Scientific Data, 2026 Dec 1; 13 (1):Journal ArticleVO: The Vaccine Ontology
DOI:10.1038/s41597-026-07298-w PMID: 42062309 -
Kay A, Mamer L, Schmitzberger F, Janke A, Omenn G, Najarian K. 2026 Oct 29;Proceeding / Abstract / PosterSurrogate Interpretable Models as Explainable Devices for LLMs Used on Unstructured Clinical Text Question & Answering
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Kay A, Takher D, Liu W, Wittrup E, Omenn GS, Najarian K. Advanced Intelligent Discovery, 2026 Sep 13;Journal ArticleCurrent Standards of Monitoring Models in Healthcare Settings
DOI:10.1002/aidi.70160 -
Ahadi S, Babačić H, Cantrell LS, Hornburg D, Müller-Reif JB, Dagley LF, Guerrera IC, Albrecht V, Edfors F, Yu X, Sun Z, Moritz RL, Schmidt F, Hauck SM, Deutsch EW, Omenn GS, Schwenk JM, Geyer PE. J Proteome Res, 2026 Sep 4; 25 (9): 4367 - 4379.Journal ArticleUnlocking the Circulating Proteome: Toward Clinical Translation.
DOI:10.1021/acs.jproteome.6c00277 PMID: 42695895 -
Sun Y, Jun A, Liu Z, Sun R, Qian L, Payne SH, Bittremieux W, Ralser M, Li C, Chen Y, Dong Z, Perez-Riverol Y, Khan A, Sander C, Aebersold R, Vizcaíno JA, Krieger JR, Yao J, Han W, Zhang L, Zhu Y, Xuan Y, Sun BB, Qiao L, Hermjakob H, Tang H, Gao H, Deng Y, Zhong Q, Chang C, Bandeira N, Li M, E W, Sun S, Yang Y, Omenn GS, Zhang Y, Xu P, Fu Y, Liu X, Overall CM, Wang Y, Deutsch EW, Chen L, Cox J, Demichev V, He F, Huang J, Jin H, Liu C, Li N, Luan Z, Song J, Yu K, Wan W, Wang T, Zhang K, Zhang L, Bell PA, Mann M, Zhang B, Guo T. Nature Methods, 2026 Sep 1; 23 (9): 1697 - 1709.Journal ArticleAI proteomics: from protein identification to virtual cells
DOI:10.1038/s41592-026-03085-y PMID: 42521824 -
Ahadi S, Hornburg D, Babačić H, Müller-Reif JB, Cantrell LS, Edfors F, Hauck SM, Deutsch EW, Omenn GS, Geyer PE, Schwenk JM. EMBO Molecular Medicine, 2026 Aug 12; 18 (8): 3011 - 3016.Journal ArticleTranslational bottlenecks in blood-based proteomics
DOI:10.1038/s44321-026-00468-8 PMID: 42265367 -
Cieslik M, Gong J, Petralia F, Cuevas MVR, Tignor N, Jain R, Gritsenko M, Chowdhury S, Kitata RB, Ma W, Hsiao Y, Deng Y, Clauser K, Byrd A, Krek A, Ibing S, Chen L, Song X, Day N, Kim H, Hu Y, Weitz K, Chu R, Lalli P, Schepmoes A, Eder J, Sagendorf T, Petyuk V, Clendinen C, Flores J, Moore R, Monroe M, Hernandez G, Ctortecka C, Verzani E, Lippincott I, Beaumont K, Li Y-C, Marino G, Yu F, Zhang Y, Cruz G, Hosseini N, Shang Y, Clark N, Newton C, Freeman M, Dou Y, Choi S, Aranha M, Edwards N, An E, Zhang X, Robles A, Lazar A, Shi T, Ding L, Zhang B, Mani DR, Omenn G, Gillette M, Carr S, Dhanasekaran S, Mesri M, Thiagarajan M, Nesvizhskii A, Zhang H, Hostetter G, Ma'ayan A, Kyle J, Abelin J, Harms P, Paulovich A, Davar D, Liu T, Wang P. Cancer Discovery, 2026 Jan 29; In Press:Journal ArticleA comprehensive proteogenomic, immunopeptidomic, and metabolomic atlas decodes immunogenicity in cutaneous melanoma
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Chu SCA, Hsiao Y, Wang C, Kyle JE, Jain R, Deng Y, Gritsenko MA, Henry LE, Lei JT, Dou Y, Tercan B, Shi Z, Gondal MN, Tsai CF, Elizarraras JM, Chu RK, Yu F, Joshi SK, Jing X, Polasky DA, Weitz KK, Li GX, Paurus VL, Clendinen CS, Schepmoes AA, Lalli PM, Eder JG, Flores JE, Stratton KG, Pino JC, Posso C, Petyuk VA, Sagendorf TJ, Xu Y, Ibrahim OM, Moore RJ, Zhao R, Chen J, Monroe ME, Thiagarajan M, Hostetter G, Newton C, An E, Robles AI, Zhang X, Edwards NJ, Lu Y, Zhang H, Abdelhakim H, Piehowski PD, Mesri M, Smith RD, Kumar-Sinha C, Tognon CE, Dunlap J, Traer E, Ding L, Tyner JW, Chinnaiyan AM, Omenn GS, Rodland KD, Dhanasekaran SM, Gosline SJC, Nesvizhiskii AI, Zhang B, Liu T, Cieslik MP, Zaalishvili K, Xu Y, Wiznerowicz M, Williams BO, Wang Y, Wang P, Wang C, Vucic M, Venkatachari S, Vatanian N, Tsai CF, Thangudu RR, Garcia-Buntley SS, Shutack Y, Satpathy S, Rudnick P, Rohrer D, Rivero G, Prilutskaya M, Potapova O, Eser PO, Pilozzi A, Pico A, Petralia F, Paulovich AG, Parolia A, Pandey A, Nyce K, Noyama J, McGarvey P, Mays M, Mannan R, Mani DR. Nature Cancer, 2026 Jun 1; 7 (6): 993 - 1015.Journal ArticleIntegrated proteogenomic and metabolomic profiling of acute myeloid leukemias to identify molecular subtypes and associated therapy targets
DOI:10.1038/s43018-026-01175-6 PMID: 42286338
Featured News & Stories
Highlighted Publications: January - May 2026
Omenn Lecture explores how AI is transforming medicine
Mark your calendars: Aviv Regev to give Omenn lecture March 25
Gil Omenn, M.D., Ph.D. Receives the prestigious AAAS Philip Hauge Abelson Prize
Highlighted Publications - January 2025