Daniel R Wahl, MD, PhD

Daniel Wahl, MD, PhD
Achtenberg Family Professor of Radiation Oncology
Associate Professor of Radiation Oncology
Associate Professor of Neurosurgery
Medical School
University of Michigan–Ann Arbor
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
[email protected]
Available to mentor
Daniel R Wahl, MD, PhD
Daniel Wahl, MD, PhD
Associate Professor
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  • Research Overview
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  • About

    Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.

    Links

    • Wahl Lab
    • Personal page on department website

    Center Memberships

    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute

    Research Overview

    Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.

    Recent Publications

    See All Publications
    • Journal Article
      H3K27M enhances basal ATM signaling but is not required for radiosensitization of diffuse midline glioma via ATM inhibition with AZD1390.
      Peterson ER, Parsels LA, Li Z, Zhao X, Hess LD, Guo Y, Messinger D, Parsels JD, Wang Z, Qin T, Valvo VM, Franson AT, Castro MG, Yadav VN, Lawrence TS, Koschmann C, Zhang Q, Wahl DR, Morgan MA. Mol Cancer Ther, 2026 Jul 14; DOI:10.1158/1535-7163.MCT-24-1019
      PMID: 42444560
    • Journal Article
      Aneuploidy selects for the acquisition of driver genes in breast cancer.
      Al-Zahrani KN, Langille ER, Nurtanto J, Obersterescu A, Teng K, Lowden C, Dessapt J, Chiu CH, Caldwell LV, Cook DP, Pérez-Castro MA, Berman JM, Tsai R, Bahcheli AT, Mbamalu G, Wu S, Narimatsu M, Lopes AG, Fotiadou I, Chan K, Zhang L, Bang KWA, Parsons MJ, Mourao L, Temel EI, McCulla L, Sravya P, Zhang L, Sajjakulnukit P, Lyssiotis CA, Borowsky AD, Scheele CLGJ, Wahl DR, Jackson HW, Stewart KS, Fuchs E, Egan SE, Pujana MA, Reimand J, Wrana JL, Schramek D. Nature, 2026 Jul 8; DOI:10.1038/s41586-026-10752-9
      PMID: 42420452
    • Journal Article
      GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.
      Pathak A, Sravya P, Colon B, Ciervo E, Zhou Y, Teran Pumar OY, León BE, Mitchell J, Assenza Tavares Coroa PH, Mateo-Victoriano B, Scott AJ, Gannamedi DP, Wong HKA, Zhang L, Lee J, Kay K, Karaca E, Chin DH, Amirian H, Karaman I, Shrestha P, Sellick K, Dean D, Bilbao Cortes D, Datta J, Welford SM, Franco MC, Kurmi K, Shah AH, Cheng F, Lathia JD, Rai P, Lombard DB, Lyssiotis CA, Watson DC, Ceccarelli M, Wahl DR, Bayik D. Nat Cancer, 2026 Jun 23; DOI:10.1038/s43018-026-01192-5
      PMID: 42337052
    • Journal Article
      Cutting through complexity: Spatial multi-omics in the fight against DIPG/DMG
      Vo T, Savary C, Jackson ER, Douglas AM, Murdoch HJ, Jayaraman R, Bessler N, Persson ML, McEwen H, McLachlan T, Duchatel RJ, Petraello B, Agnihotri S, Anastas J, Baker SJ, Becher OJ, Castel D, Chavez L, Koldobskiy MA, Deogharkar A, Mota M, Dirks PB, Doherty R, de la Nava D, Duncan B, du Chatinier A, Galban S, Marques JG, Hanson CM, Hara T, Herrington C, Ji S, Jones C, Kleinman CL, Krug B, Lin FY, Lu QR, Messinger D, Mody RJ, Mukherji D, Parthasarathy A, Peterson E, Phoenix TN, Pichumani K, Prensner JR, Ramakrishna S, Ramsoomair CK, Sajjakulnukit P, Sarmashghi S, Syed S, Tamplin OJ, Trout M, Freytag S, Valvo VM, Wahl DR, Al-Holou WN, Wechsler-Reya RJ, Koschmann C, Venneti S, Filbin MG, Dun MD. Neuro-Oncology Pediatrics, 2026 Jun 7; wuag036 DOI:10.1093/neuped/wuag036
    • Journal Article
      Brain cells refine nitrogen choice with maturity.
      Scott AJ, Lyssiotis CA, Wahl DR. Nat Metab, 2026 Apr 29; DOI:10.1038/s42255-026-01519-7
      PMID: 42056504
    • Journal Article
      393 THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors
      Syed S, Tripathy A, Ji S, Alomary Y, de la Nava Martin D, Mota M, Chakravarthy R, Huang D-L, Wang Z, Li Z, Zhang Q, Lawrence T, Wahl D, Koschmann C, Venneti S, Rehemtulla A, Al-Holou W. Neurosurgery, 2026 Mar 17; 72 (Supplement_1): 109 - 109. DOI:10.1227/neu.0000000000003964_393
    • Presentation
      Measuring and targeting altered metabolism in brain cancer
      Wahl D. 2026 May 20;
    • Presentation
      What Reviewers Look for in Your RPG Application: Perspectives from Reviewers
      Hong C-C, Wahl D, Bogler O. 2026 May 20;

    Featured News & Stories

    Department News

    Brain cancer digital twin predicts treatment outcomes

    A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.
    light blue background with pink brain with red circle area growing
    Health Lab

    Dietary changes could provide a therapeutic avenue for brain cancer

    A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.
    Max Wicha, M.D. and Sunitha Nagrath, Ph.D.  Photo credit: Leisa Thompson
    Illuminate

    Nurturing High-Risk, High-Reward Ideas

    The Forbes Institute fosters cross-disciplinary collaboration, encouraging partnerships among faculty from various disciplines across the University of Michigan campus. Learn more about their research into tumor dormancy.
    The Achtenberg family dressed in Michigan gear at University Hospital.
    Philanthropy News

    Dedicated football fans create professorship for life-saving research after wife’s glioblastoma treatment

    U-M football fans Jim and Connie Achtenberg are turning their experience with glioblastoma into hope by funding research at Rogel Cancer Center.