Daniel R Wahl, MD, PhD
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
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About
Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.
Links
Wahl Lab Personal page on department website
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberTaubman Institute
Research Overview
Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.
Recent Publications
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Peterson ER, Parsels LA, Li Z, Zhao X, Hess LD, Guo Y, Messinger D, Parsels JD, Wang Z, Qin T, Valvo VM, Franson AT, Castro MG, Yadav VN, Lawrence TS, Koschmann C, Zhang Q, Wahl DR, Morgan MA. Mol Cancer Ther, 2026 Jul 14;Journal ArticleH3K27M enhances basal ATM signaling but is not required for radiosensitization of diffuse midline glioma via ATM inhibition with AZD1390.
DOI:10.1158/1535-7163.MCT-24-1019 PMID: 42444560 -
Al-Zahrani KN, Langille ER, Nurtanto J, Obersterescu A, Teng K, Lowden C, Dessapt J, Chiu CH, Caldwell LV, Cook DP, Pérez-Castro MA, Berman JM, Tsai R, Bahcheli AT, Mbamalu G, Wu S, Narimatsu M, Lopes AG, Fotiadou I, Chan K, Zhang L, Bang KWA, Parsons MJ, Mourao L, Temel EI, McCulla L, Sravya P, Zhang L, Sajjakulnukit P, Lyssiotis CA, Borowsky AD, Scheele CLGJ, Wahl DR, Jackson HW, Stewart KS, Fuchs E, Egan SE, Pujana MA, Reimand J, Wrana JL, Schramek D. Nature, 2026 Jul 8;Journal ArticleAneuploidy selects for the acquisition of driver genes in breast cancer.
DOI:10.1038/s41586-026-10752-9 PMID: 42420452 -
Pathak A, Sravya P, Colon B, Ciervo E, Zhou Y, Teran Pumar OY, León BE, Mitchell J, Assenza Tavares Coroa PH, Mateo-Victoriano B, Scott AJ, Gannamedi DP, Wong HKA, Zhang L, Lee J, Kay K, Karaca E, Chin DH, Amirian H, Karaman I, Shrestha P, Sellick K, Dean D, Bilbao Cortes D, Datta J, Welford SM, Franco MC, Kurmi K, Shah AH, Cheng F, Lathia JD, Rai P, Lombard DB, Lyssiotis CA, Watson DC, Ceccarelli M, Wahl DR, Bayik D. Nat Cancer, 2026 Jun 23;Journal ArticleGABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.
DOI:10.1038/s43018-026-01192-5 PMID: 42337052 -
Vo T, Savary C, Jackson ER, Douglas AM, Murdoch HJ, Jayaraman R, Bessler N, Persson ML, McEwen H, McLachlan T, Duchatel RJ, Petraello B, Agnihotri S, Anastas J, Baker SJ, Becher OJ, Castel D, Chavez L, Koldobskiy MA, Deogharkar A, Mota M, Dirks PB, Doherty R, de la Nava D, Duncan B, du Chatinier A, Galban S, Marques JG, Hanson CM, Hara T, Herrington C, Ji S, Jones C, Kleinman CL, Krug B, Lin FY, Lu QR, Messinger D, Mody RJ, Mukherji D, Parthasarathy A, Peterson E, Phoenix TN, Pichumani K, Prensner JR, Ramakrishna S, Ramsoomair CK, Sajjakulnukit P, Sarmashghi S, Syed S, Tamplin OJ, Trout M, Freytag S, Valvo VM, Wahl DR, Al-Holou WN, Wechsler-Reya RJ, Koschmann C, Venneti S, Filbin MG, Dun MD. Neuro-Oncology Pediatrics, 2026 Jun 7; wuag036Journal ArticleCutting through complexity: Spatial multi-omics in the fight against DIPG/DMG
DOI:10.1093/neuped/wuag036 -
Scott AJ, Lyssiotis CA, Wahl DR. Nat Metab, 2026 Apr 29;Journal ArticleBrain cells refine nitrogen choice with maturity.
DOI:10.1038/s42255-026-01519-7 PMID: 42056504 -
Syed S, Tripathy A, Ji S, Alomary Y, de la Nava Martin D, Mota M, Chakravarthy R, Huang D-L, Wang Z, Li Z, Zhang Q, Lawrence T, Wahl D, Koschmann C, Venneti S, Rehemtulla A, Al-Holou W. Neurosurgery, 2026 Mar 17; 72 (Supplement_1): 109 - 109.Journal Article393 THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors
DOI:10.1227/neu.0000000000003964_393 -
Wahl D. 2026 May 20;PresentationMeasuring and targeting altered metabolism in brain cancer
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Hong C-C, Wahl D, Bogler O. 2026 May 20;PresentationWhat Reviewers Look for in Your RPG Application: Perspectives from Reviewers
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