Daniel R Wahl, MD, PhD
Achtenberg Family Professor of Radiation Oncology
Associate Professor of Radiation Oncology and Associate Professor of Neurosurgery
Medical School
Office:
University of Michigan–Ann Arbor
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
Email:
[email protected]
Phone:
Available to mentor
Daniel R Wahl, MD, PhD
Professor
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About
Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.
Links
Wahl Lab Personal page on department website
Center Memberships
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Center MemberRogel Cancer Center
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Center MemberTaubman Institute
Research Overview
Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.
Recent Publications
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Peterson ER, Parsels LA, Li Z, Zhao X, Hess LD, Guo Y, Messinger D, Parsels JD, Wang Z, Qin T, Valvo VM, Franson AT, Castro MG, Yadav VN, Lawrence TS, Koschmann C, Zhang Q, Wahl DR, Morgan MA. Mol Cancer Ther, 2026 Jul 14;Journal ArticleH3K27M enhances basal ATM signaling but is not required for radiosensitization of diffuse midline glioma via ATM inhibition with AZD1390.
DOI:10.1158/1535-7163.MCT-24-1019 PMID: 42444560 -
Pathak A, Sravya P, Colon B, Ciervo E, Zhou Y, Teran Pumar OY, León BE, Mitchell J, Assenza Tavares Coroa PH, Mateo-Victoriano B, Scott AJ, Gannamedi DP, Wong HKA, Zhang L, Lee J, Kay K, Karaca E, Chin DH, Amirian H, Karaman I, Shrestha P, Sellick K, Dean D, Bilbao Cortes D, Datta J, Welford SM, Franco MC, Kurmi K, Shah AH, Cheng F, Lathia JD, Rai P, Lombard DB, Lyssiotis CA, Watson DC, Ceccarelli M, Wahl DR, Bayik D. Nature Cancer, 2026 Jul 1; 7 (7): 1080 - 1093.Journal ArticleGABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells
DOI:10.1038/s43018-026-01192-5 PMID: 42337052 -
Vo T, Savary C, Jackson ER, Douglas AM, Murdoch HJ, Jayaraman R, Bessler N, Persson ML, McEwen H, McLachlan T, Duchatel RJ, Petraello B, Agnihotri S, Anastas J, Baker SJ, Becher OJ, Castel D, Chavez L, Koldobskiy MA, Deogharkar A, Mota M, Dirks PB, Doherty R, de la Nava D, Duncan B, du Chatinier A, Galban S, Marques JG, Hanson CM, Hara T, Herrington C, Ji S, Jones C, Kleinman CL, Krug B, Lin FY, Lu QR, Messinger D, Mody RJ, Mukherji D, Parthasarathy A, Peterson E, Phoenix TN, Pichumani K, Prensner JR, Ramakrishna S, Ramsoomair CK, Sajjakulnukit P, Sarmashghi S, Syed S, Tamplin OJ, Trout M, Freytag S, Valvo VM, Wahl DR, Al-Holou WN, Wechsler-Reya RJ, Koschmann C, Venneti S, Filbin MG, Dun MD. Neuro-Oncology Pediatrics, 2026 Jun 7; 2 (3): wuag036Journal ArticleCutting through complexity: Spatial multi-omics in the fight against diffuse intrinsic pontine glioma/diffuse midline glioma
DOI:10.1093/neuped/wuag036 -
Scott AJ, Lyssiotis CA, Wahl DR. Nature Metabolism, 2026 May 1; 8 (5): 1006 - 1008.Journal ArticleBrain cells refine nitrogen choice with maturity
DOI:10.1038/s42255-026-01519-7 PMID: 42056504 -
Syed S, Tripathy A, Ji S, Alomary Y, de la Nava Martin D, Mota M, Chakravarthy R, Huang D-L, Wang Z, Li Z, Zhang Q, Lawrence T, Wahl D, Koschmann C, Venneti S, Rehemtulla A, Al-Holou W. Neurosurgery, 2026 Apr 24; 72 (Supplement_1): 109 - 109.Proceeding / Abstract / Poster393 THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors
DOI:10.1227/neu.0000000000003964_393 -
Wang K, Deal AM, Shen CJ, Pacholke HD, Wardell A, Pearlstein KA, Weiner AA, Xu V, Danquah F, Wahl DR, Jackson WC, Dess RT, Dragovic AF, Shah JL, Dow J, Mierzwa ML, Lawrence TS, Marks LB, Chera BS, Kim MM. International Journal of Radiation Oncology Biology Physics, 2026 Mar 15; 124 (4): 1024 - 1032.Journal ArticleParotid-Sparing Versus Conventional Whole Brain Radiation Therapy: A Multi-Institutional Randomized Clinical Trial
DOI:10.1016/j.ijrobp.2025.10.022 PMID: 41161645 -
Wahl D. 2026 May 20;PresentationMeasuring and targeting altered metabolism in brain cancer
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Hong C-C, Wahl D, Bogler O. 2026 May 20;PresentationWhat Reviewers Look for in Your RPG Application: Perspectives from Reviewers
Featured News & Stories
Department News
Brain cancer digital twin predicts treatment outcomes
A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.
Health Lab
Dietary changes could provide a therapeutic avenue for brain cancer
A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.
Illuminate
Nurturing High-Risk, High-Reward Ideas
The Forbes Institute fosters cross-disciplinary collaboration, encouraging partnerships among faculty from various disciplines across the University of Michigan campus. Learn more about their research into tumor dormancy.
Philanthropy News
Dedicated football fans create professorship for life-saving research after wife’s glioblastoma treatment
U-M football fans Jim and Connie Achtenberg are turning their experience with glioblastoma into hope by funding research at Rogel Cancer Center.
