Daniel R Wahl, MD, PhD

 Daniel Wahl, MD, PhD
Professor
Office:
University of Michigan–Ann Arbor
Department of Radiation Oncology
1500 East Medical Center Drive, UH B2C490 SPC 5010
Ann Arbor, MI 48109-5010
Email:
[email protected]
Phone:
Available to mentor
Daniel R Wahl, MD, PhD
Daniel Wahl, MD, PhD
Professor
  • About
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  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Dr. Wahl is a physician scientist at the University of Michigan specializing in cancers of the central nervous system. His research focuses on the development of new treatment strategies for brain tumors and his laboratory group is especially interested in interactions between radiation and abnormal metabolism in glioblastoma. In the clinic, he cares for a wide variety of patients with both malignant and benign tumors of the central nervous system.

    Links
    • Wahl Lab
    • Personal page on department website

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Taubman Institute

    Research Overview

    Dr. Wahl's research focuses on developing strategies to overcome treatment resistance in aggressive brain tumors. He has a particular interest in understanding and interrupting the links between altered metabolism and radiation resistance in glioblastoma.

    Recent Publications

     See All Publications
    • Presentation
      Measuring and Targeting Altered Metabolism in Glioblastoma
      Wahl D. 2026 Oct 22;
    • Presentation
      Measuring and Targeting Metabolism in Brain Cancer
      Wahl D. 2026 Oct 22;
    • Preprint
      Lactate epigenetically shapes tumor cell states in H3K27M diffuse midline gliomas
      Lum J, Nuechterlein N, Sliger S, Eyunni S, Tamrazi B, Blüml S, Tian W, Deogharkar A, Sweha SR, Mota M, Bayliss J, Peterson E, Ji S, Wittwer M, Bhat K, Mott BT, Hamanishi ET, Merkuri F, Azambuja A, Conceicao H, Su F, Cao X, Pandey R, Ljare OB, Parolia A, Yadav VN, Wahl DR, Koschmann C, Simoes-Costa M, Pichumani K, Wang S, Chinnaiyan AM, Venneti S. 2026 Oct 8; bioRxiv, DOI:10.64898/2026.10.02.756321
    • Journal Article
      Hypoxia? NNoT a PROblem!
      Liang N, Lyssiotis CA, Wahl DR. Molecular Cell, 2026 Oct 1; 86 (19): 3862 - 3863. DOI:10.1016/j.molcel.2026.09.007
      PMID: 42822414
    • Journal Article
      Microenvironment-derived acetylated amino acids promote glioblastoma treatment resistance.
      Sravya P, Altay LN, Do K, Freeman J, Gokul A, Liang N, Scott AJ, Xu J, Korimerla N, Lin A, Wang H, Wilder-Romans K, Singer A, O'Brien A, Animasahun O, Meghdadi B, Baker E, Peterson ER, McCulla EC, Zhu Z, Thomas D, Andren A, Wong H, Sajjakulnukit P, Zhang L, Shankar S, Ravikumar V, Lee ZH, Carrion JAN, Bhadury S, Miller CR, Sarkaria JN, Heth JA, Huse JT, Camelo-Piragua S, Morgan MA, Lawrence TS, Rao A, Lyssiotis C, Al-Holou W, Nagrath D, Zhou W, Wahl DR. Res Sq, 2026 Sep 18; DOI:10.21203/rs.3.rs-10976328/v1
      PMID: PMC13596666
    • Preprint
      Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers.
      Huang Y, McCulla E, Park J, Yang A, Jho T, Lin A, Xu J, Wilder-Romans K, Hess LD, Li J, Liang N, Zhu Z, Kothari D, Jin K, Kim S, Premathilaka SH, Wen B, Sun D, Vinco M, Ferris SP, Morgan MA, Lawrence TS, Shah YM, Yu M, Heft Neal ME, Brenner JC, Dharmawardhane S, Rodriguez-Orengo JF, Wahl DR, Zhou W. 2026 Sep 18; DOI:10.64898/2026.09.11.750952
      PMID: 42779662
    • Journal Article
      Aneuploidy selects for the acquisition of driver genes in breast cancer
      Al-Zahrani KN, Langille ER, Nurtanto J, Obersterescu A, Teng K, Lowden C, Dessapt J, Chiu CH, Caldwell LV, Cook DP, Pérez-Castro MA, Berman JM, Tsai R, Bahcheli AT, Mbamalu G, Wu S, Narimatsu M, Lopes AG, Fotiadou I, Chan K, Zhang L, Bang KWA, Parsons MJ, Mourao L, Temel EI, McCulla L, Sravya P, Zhang L, Sajjakulnukit P, Lyssiotis CA, Borowsky AD, Scheele CLGJ, Wahl DR, Jackson HW, Stewart KS, Fuchs E, Egan SE, Pujana MA, Reimand J, Wrana JL, Schramek D. Nature, 2026 Sep 17; 657 (8132): 800 - 810. DOI:10.1038/s41586-026-10752-9
      PMID: 42420452
    • Journal Article
      Initial outcomes from a phase II study of multiparametric MR-guided high-dose response adaptive radiotherapy with concurrent temozolomide in patients with newly diagnosed glioblastoma
      Kim MM, Aryal MP, Rosen BS, Parmar HA, You D, Leung D, Clarke N, Fortunato J, Al-Holou W, Heth JA, Altshuler D, Hollon T, Kalandjian M, Sharp J, Edwards DM, Wahl DR, Lawrence TS, Suresh K, Cao Y. International Journal of Radiation Oncology • Biology • Physics, 2026 Sep 27; 126 (1): s111 DOI:10.1016/j.ijrobp.2026.06.153

    Featured News & Stories
    Department News

    Brain cancer digital twin predicts treatment outcomes

    A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.
         light blue background with pink brain with red circle area growing
    Health Lab

    Dietary changes could provide a therapeutic avenue for brain cancer

    A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.
         Max Wicha, M.D. and Sunitha Nagrath, Ph.D. Photo credit: Leisa Thompson
    Illuminate

    Nurturing High-Risk, High-Reward Ideas

    The Forbes Institute fosters cross-disciplinary collaboration, encouraging partnerships among faculty from various disciplines across the University of Michigan campus. Learn more about their research into tumor dormancy.
         The Achtenberg family dressed in Michigan gear at University Hospital.
    Philanthropy News

    Dedicated football fans create professorship for life-saving research after wife’s glioblastoma treatment

    U-M football fans Jim and Connie Achtenberg are turning their experience with glioblastoma into hope by funding research at Rogel Cancer Center.