Changyang Linghu
Michigan Neuroscience Institute
2800 Plymouth Rd
Ann Arbor, MI 48109
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About
Changyang Linghu is an assistant professor in the Department of Cell and Developmental Biology, member of the Single Cell Spatial Analysis Program and the Michigan Neuroscience Institute, and affiliate faculty in the Department of Biomedical Engineering at the University of Michigan, Ann Arbor. Before joining U-M, he obtained a Bachelor of Engineering from Tsinghua University and completed his Ph.D. at Massachusetts Institute of Technology working with Dr. Ed Boyden. His lab (Spatial Biodynamics Lab: spatialbiodynamics.org) is on a mission to unravel emergent properties of cell populations that drive essential brain functions, via scalable and multiplexable interrogation of cell physiology in vivo.
Dr. Linghu is the recipient of the Klingenstein Fellowship Award in Neuroscience (2025), Research Scout Scholar from UMich (2025), NIH Director's New Innovator Award (2024), MIT Technology Review's Global 35 Innovators Under 35 (TR35) (2024), Glenn and AFAR Junior Faculty Grant (2024), Chan Zuckerberg Initiative Collaborative Pairs Pilot Project Award (2024), Whitehall Foundation Three-Year Research Grant (2024), GenScript Life Science Research Grant (2024), Bioengineering in Brain Cancer Challenge Seed Fund Award from UMich (2024), Spatial Analytics of Cancer Challenge Seed Fund Award from UMich (2023), Biological Sciences Scholar (BSSP) from UMich (2022), MIT Spot Award (for community service) (2022), MIT Technology Review 35 Innovators Under 35 China (TR35 China) (2021), Bioengineering Rising Star Speaker from Princeton University (2021), J. Douglas Tan Postdoctoral Fellow (2020), McGovern Graduate Fellow (2018), and MIT Presidential Fellow (supported by Irwin Mark Jacobs and Joan Klein Jacobs) (2013).
The Spatial Biodynamics Lab is at the intersection of the Medical School, Neuroscience Institute, Biosciences Initiative, and Biomedical Engineering at the University of Michigan, and provides a unique and world's top interdisciplinary research and training environment.
Links
Spatial Biodynamics Lab Google Scholar X (Twitter) linkedin Bluesky
Qualifications
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J. Douglas Tan Postdoctoral FellowMassachusetts Institute of Technology, McGovern Institute for Brain Research, Cambridge, United States
2020 - 2022
Postdoctoral Fellowship
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Ph.D.Massachusetts Institute of Technology, Cambridge, United States
2013 - 2019
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M.S.Massachusetts Institute of Technology, Cambridge, United States
2013 - 2016
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B.E.Tsinghua University, Beijing, China
2009 - 2013
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Exchange Undergrad CertificateUniversity of Wisconsin–Madison, Madison, United States
2011 - 2012
Research Overview
Biotechnology, Neuroscience, Molecular Recording, Biosensors and Bioactuators, Biomedical and Optical Imaging, Protein Engineering, Signaling Network Dynamics, Gene Expression Histories, Mechanobiology
Recent Publications
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Shi D, Hou Y, Yan Y, Zhang T-H, Joesten WC, Liu P, Wang Y, Gautam M, Lim J, Zheng L, Gould J, Ko B, Niu X, Cheng M-C, Hsieh J-C, Levet F, Cai D, Draelos A, Cai DJ, Wei D, Linghu C. 2026 May 24; bioRxiv,PreprintSimultaneous brain-wide single-cell recording resolves spatiotemporal memory architecture
DOI:10.64898/2026.05.21.726120 -
Zheng L, Shi D, Yan Y, Zhou B, Lim J, Hou Y, An B, Adhinarta JK, Lin M, Ko B, Joesten WC, Gautam M, Huez EDM, Kim EC, Klyder EG, Chang B, Pitchiaya S, Roberts MT, Cai DJ, Boyden ES, Wei D, Liò P, Linghu C. Nature, 2026 Jan 26;Journal ArticleScalable and multiplexed recorders of gene regulation dynamics across weeks.
DOI:10.1038/s41586-026-10156-9 PMID: 41588170 -
Chaikof EL, Chen J, Gillette MU, Boyer LA, Deans TL, Li P, Hilton IB, Daniels K, Goyal Y, Mei Y, Linghu C, Loveless TB, Truong DM, Blatchley MR, Gu M, Bashor CJ, Yang JH, Raman R, Reddy AB, Saha K, Davis J, Gupta K, Gao XJ, Galloway KE. Cell Systems, 2025 Dec 17; 16 (12):Journal ArticleIntegrating synthetic biology to understand and engineer the heart, lung, blood, and sleep systems
DOI:10.1016/j.cels.2025.101446 PMID: 41412113 -
Zheng L, Yan Y, Zhou B, Lim J, Shi D, An B, Ko B, Klyder E, Pitchiaya S, Cai DJ, Boyden ES, Wei D, Liò P, Linghu C. 2025 May 10;PreprintMultiplexed, scalable analog recording of gene regulation dynamics over weeks using intracellular protein tapes.
DOI:10.1101/2025.05.10.653182 PMID: 40654887 -
Zhang J, Newman J, Wang Z, Qian Y, Feliciano-Ramos P, Guo W, Honda T, Chen ZS, Linghu C, Etienne-Cummings R, Fossum E, Boyden E, Wilson M. Nature Communications, 2024 Dec 1; 15 (1):Journal ArticlePixel-wise programmability enables dynamic high-SNR cameras for high-speed microscopy
DOI:10.1038/s41467-024-48765-5 PMID: 38802338 -
Linghu C, An B, Shpokayte M, Celiker OT, Shmoel N, Zhang R, Zhang C, Park D, Park WM, Ramirez S, Boyden ES. Nature Biotechnology, 2023 May 1; 41 (5): 640 - 651.Journal ArticleRecording of cellular physiological histories along optically readable self-assembling protein chains
DOI:10.1038/s41587-022-01586-7 PMID: 36593405 -
Linghu C, Chen IW, Tanese D, Zampini V, Shemesh OA. 2022 Jan 1; 2501: Methods in Molecular Biology, 229 - 257.ChapterSingle-Cell Resolution Optogenetics Via Expression of Soma-Targeted Rhodopsins
DOI:10.1007/978-1-0716-2329-9_11 PMID: 35857231 -
Linghu C, Johnson SL, Valdes PA, Shemesh OA, Park WM, Park D, Piatkevich KD, Wassie AT, Liu Y, An B, Barnes SA, Celiker OT, Yao CC, Yu CC, Wang R, Adamala KP, Bear MF, Keating AE, Boyden ES. Cell, 2020 Dec 10; 183 (6): 1682 - 1698.e24.Journal ArticleSpatial Multiplexing of Fluorescent Reporters for Imaging Signaling Network Dynamics
DOI:10.1016/j.cell.2020.10.035 PMID: 33232692
Featured News & Stories
A protein tape-recorder enables scientists to measure and decode cellular processes at scale and over time
