Catherine C Kaczorowski, BA, PhD
Elinor Levine Professor of Dementia Research and Professor of Neurology
Medical School
[email protected]
Available to mentor
Catherine C Kaczorowski, BA, PhD
Professor
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Qualifications
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FellowshipMedical College of Wisconsin, Neuroproteomics of Alzheimer's, Milwaukee, WI, United States
2009 - 2012
Postdoctoral Fellowship
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FellowshipUniversity of Wisconsin–Milwaukee, Psychology, Cognitive Aging, Milwaukee, WI, United States
2007 - 2009
Postdoctoral Fellowship
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PhDNorthwestern University - Institue for Neuroscience, Evanston, IL, United States
2001 - 2006
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BAUniversity of Wisconsin–Milwaukee, Milwaukee, WI, United States
1997 - 2000
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N/AFront Range Community College, Westminster, CO, United States
1996 - 1997
Center Memberships
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberAI and Digital Health Innovation
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Center MemberFrankel Institute for Heart and Brain Health
Research Overview
My laboratory pioneers techniques to identify and validate genetic and cellular mechanisms that promote resilience to cognitive aging, Alzheimer's disease, and other age-related dementias. By combining mouse and human systems; genomic, anatomic, and behavioral approaches; and integrative analyses across multiple scales, data types, environmental factors, and species, we are accelerating discovery of the precise genetic mechanisms of cognitive resilience that could yield the next generation of targets and therapeutic strategies for promoting brain health. We are now uniquely poised to propel the field of personalized medicine forward using our genetically diverse, yet reproducible models of human neurodegenerative dementias, having already contributed conceptual and technical advances that revolutionized our ability to study complex diseases, specifically human AD dementia.
Recent Publications
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Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet, 2021 Apr; 17 (4): e1009406Proceeding / Abstract / PosterPLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.
DOI:10.1371/journal.pgen.1009406 PMID: PMC8031396 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao P-C, Tsai L-H, Haure-Mirande J-V, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein H-U, Accelerating Medicines Partnership-Alzheimer’s Disease Consortium , Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Cell Rep, 2020 Jul 14; 32 (2): 107908Journal ArticleMeta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
DOI:10.1016/j.celrep.2020.107908 PMID: PMC7428328 -
Wan Y-W, Al-Ouran R, Mangleburg CG, Lee TV, Allison K, Neuner S, Kaczorowski C, Phillip V, Howell G, Martini-Stoica H, Zheng H, Kim JW, Dawson V, Dawson T, Pao P-C, Tsai L-H, Haure-Mirande J-V, Wang M, Ehrlich ME, Mei H, Zhong X, Chakrabarty P, Levites Y, Golde TE, Levey AI, Consortium AMP-AD, Logsdon B, Mangravite L, Liu Z, Shulman JM. 2019 Jan 6; bioRxiv,PreprintFunctional dissection of Alzheimer’s disease brain gene expression signatures in humans and mouse models
DOI:10.1101/506873 -
Grudny MM, Rodriguez N, Murdy TJ, Simon ZD, Vo Q, Li W, Burns MR, Lamb DG, Kaczorowski CC, Chakrabarty P, Febo M. 2026 Apr 29;PreprintDissociable species-specific impact of Aβ on static and dynamic functional connectomes.
DOI:10.64898/2026.04.26.720907 PMID: 42094552 -
Korstanje R, Strong R, Salmon AB, Bogue MA, Curran SP, Diaz V, Fernandez E, Ginsburg B, Han M, Harrison DE, Kaczorowski C, Kaeberlein M, Kennedy BK, Kumar N, LaCroix-Fralish M, Leiser SF, Nelson JF, Polymenis M, Reifsnyder PC, Rosenthal NA, Silva E, Tower J, Miller RA. Geroscience, 2026 Jan 1;Journal ArticleAstaxanthin, meclizine, mitoglitazone, pioglitazone, alpha-ketoglutarate, mifepristone, methotrexate, and atorvastatin-telmisartan do not increase lifespan in UM-HET3 mice
DOI:10.1007/s11357-026-02201-2 -
Tian Y, Hornburg K, Austin W, Cook JJ, Qi Y, White LE, Killmar JT, Kaczorowski CC, Ashbrook DG, Johnson GA, Williams RW. Nature Neuroscience, 2026 Jan 1;Journal ArticleMagnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice
DOI:10.1038/s41593-025-02199-4 PMID: 41748785 -
Gómez-Pascual A, Glikman DM, Ng HX, Tomkins JE, Lu L, Xu Y, Ashbrook DG, Kaczorowski C, Kempermann G, Killmar J, Mozhui K, Ohlenschläger O, Aebersold R, Ingram DK, Williams EG, Jucker M, Overall RW, Williams RW, de Bakker DEM. Cell Systems, 2026 Jan 1;Journal ArticleThe Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus
DOI:10.1016/j.cels.2025.101488 -
Fish LA, Canchi S, Telpoukhovskaia M, Luquez T, Algoo J, Hadad N, Gurdon B, Dai M, Ouellette AR, Neuner SM, Dunn AR, Willcox JAL, Wu Y, Dumitrescu L, Bellur O, Zhang J, O'Connell KM, Dammer EB, Seyfried NT, Muzumdar S, Gillis J, Robson P, Arnold M, Hohman TJ, Philip VM, Menon V, Kaczorowski CC. Alzheimers Dement, 2025 Dec; 21 Suppl 1 (Suppl 1): e096281Journal ArticleBasic Science and Pathogenesis.
DOI:10.1002/alz70855_096281 PMID: PMC12725527
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