Available to mentor
My background includes Ph.D. in cell and developmental biology (Russian Academy of Sciences), postdoctoral work at the University of Colorado at Boulder and nine years of bioinformatics work in Pharmaceutical industry (at Pharmacia and at Pfizer). I have broad experience in identification and validation of therapeutic targets in variety of disease areas including antibacterials, CNS and dermatology. I am also interested in structural aspects of drug/target interactions and the integration of chemical and genomic domains.
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Center MemberCaswell Diabetes Institute
My research interests involve the analysis of high throughout omics data, focusing primarily on metabolomics, and the development of computational methods and tools for the analysis and integration of metabolomics data with other types of genomic data. I am also interested in biomedical ontologies and one of my current projects involves the development of Informed Consent Ontology.
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Habra H, Meijer JL, Shen T, Fiehn O, Gaul DA, Fernández FM, Rempfert KR, Metz TO, Peterson KE, Evans CR, Karnovsky A. Metabolites, 2024 Feb 15; 14 (2):Journal ArticlemetabCombiner 2.0: Disparate Multi-Dataset Feature Alignment for LC-MS Metabolomics.
DOI:10.3390/metabo14020125 PMID: 38393017 -
Iyer G, Brandenburg M, Patsalis C, Michailidis G, Karnovsky A. J Vis Exp, 2023 Nov 10; (201):Journal ArticleCorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data.
DOI:10.3791/65512 PMID: 38009735 -
Su AL, Harris SM, Elkin ER, Karnovsky A, Colacino J, Loch-Caruso RK. Chem Res Toxicol, 2023 Jun 19; 36 (6): 882 - 899.Journal ArticleTrichloroethylene Metabolite S-(1,2-Dichlorovinyl)-l-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytialization.
DOI:10.1021/acs.chemrestox.3c00007 PMID: 37162359 -
Jennaro TS, Puskarich MA, Evans CR, Karnovsky A, Flott TL, McLellan LA, Jones AE, Stringer KA. Crit Care Explor, 2023 Apr; 5 (4): e0881Journal ArticleSustained Perturbation of Metabolism and Metabolic Subphenotypes Are Associated With Mortality and Protein Markers of the Host Response.
DOI:10.1097/CCE.0000000000000881 PMID: 36998529 -
Goutman SA, Boss J, Iyer G, Habra H, Savelieff MG, Karnovsky A, Mukherjee B, Feldman EL. Muscle Nerve, 2023 Mar; 67 (3): 208 - 216.Journal ArticleBody mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles.
DOI:10.1002/mus.27744 PMID: 36321729 -
Lee J, Costa-Dookhan K, Panganiban K, MacKenzie N, Treen QC, Chintoh A, Remington G, Müller DJ, Sockalingam S, Gerretsen P, Sanches M, Karnovsky A, Stringer KA, Ellingrod VL, Tso IF, Taylor SF, Agarwal SM, Hahn MK, Ward KM. Front Psychiatry, 2023 14: 1169787Journal ArticleMetabolomic signatures associated with weight gain and psychosis spectrum diagnoses: A pilot study.
DOI:10.3389/fpsyt.2023.1169787 PMID: 37168086 -
Habra H, Kachman M, Padmanabhan V, Burant C, Karnovsky A, Meijer J. J Proteome Res, 2022 Dec 2; 21 (12): 2936 - 2946.Journal ArticleAlignment and Analysis of a Disparately Acquired Multibatch Metabolomics Study of Maternal Pregnancy Samples.
DOI:10.1021/acs.jproteome.2c00371 PMID: 36367990 -
Jennaro TS, Puskarich MA, Karnovsky A, Evans CR, Jones AE, Stringer KA. 2022 May; a5155 - a5155.Proceeding / Abstract / PosterEarly Metabolic Profiles of Patients with Septic Shock Reveal Distinct Patient Clustering Characterized by Ongoing Metabolic Dysfunction and Differential Mortality
DOI:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5155
