Adam Courtney, PhD

 headshot of Adam Courtney
Assistant Professor
Office:
University of Michigan Medical School
Pharmacology
1150 W. Medical Center Dr. MSRB3 2220E
Ann Arbor, Michigan 48109
Email:
[email protected]
Available to mentor
Adam Courtney, PhD
headshot of Adam Courtney
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

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    • Qualifications
    • Cancer Research Institute (CRI) Fellow
      University of California, San Francisco, San Francisco, CA, United States
      2012 - 2018
      Postdoctoral Research
    • PhD, Biochemistry
      University of Wisconsin, Madison, Madison, WI, United States
      2004 - 2011
    • BS, Biochemistry
      University of Waterloo, Waterloo, Ontario, Canada
      1999 - 2004

    Center Memberships
    • Center Member
      Rogel Cancer Center

    Research Overview

    My research group at the University of Michigan seeks to evaluate how modulation of T cell signaling pathways can alter an immune response to cancer. My research group investigates the specialized signaling pathways found in T cells. Because these signaling pathways coordinate T cell function, in principle, we should be able to manipulate them to better harness T cells as therapeutic entities for the treatment of disease.

    Links
    • Courtney Lab

    Recent Publications

     See All Publications
    • Journal Article
      Abstract B113: Rewiring T cell signaling to activate STAT proteins in T cells that target pancreatic cancer
      Rosario-Crespo A, Aleck GA, Jin Y, Castaneda NM, Pfieffer EL, Chanda MK, Courtney AH. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b113 - b113. DOI:10.1158/1538-7445.pancreatic26-b113
    • Journal Article
      CRISPR-Cas9 screen identifies eIF4G2 as a regulator of CD8+ T cell dysfunction
      Holcomb EA, Jiang L, Pearson AN, James J, Tate A, Wang A, Dasgupta A, Clauwaert J, Armas ND, Elaimy AL, Palagama DS, Goodwin SK, Kwiatkowski MH, Morgan MA, Courtney AH, Gijón M, Carty SA, Huber AK, Zou W, Prensner JR, Green MD. Journal of Immunology, 2026 Sep 22;
    • Journal Article
      Regulation of immune-cell signaling and function by the Src-family kinases
      Sauer ML, Courtney AH, Zikherman J, Freedman TS. Annual Reviews of Immunology, 2026 Sep 22; 45:
    • Journal Article
      Targeting CCR1 Remodels the Tumor Microenvironment and Relieves Immunosuppression in Pancreatic Cancer
      Zhang Y, Kadiyala P, Yan W, Brown K, Avritt FR, Donahue KL, Procario MC, Okoye JO, Giridharan T, Elhossiny AM, Espinoza CE, Awad D, Lasse Opsahl EL, Medina-Cabrera PI, Velez-Delgado A, Menjivar RE, Yang OA, Yang S, He X, Gupta S, Tariq R, Brandt AR, Wang X, Dendekker A, Nwosu ZC, Carpenter ES, Courtney AH, Bednar F, Frankel TL, Lyssiotis CA, Zheng B, Kryczek I, Pasca Di Magliano M. Cancer Immunology Research, 2026 Aug 1; 14 (8): 1233 - 1253. DOI:10.1158/2326-6066.CIR-25-1300
      PMID: 42207977
    • Presentation
      Rewiring signaling pathways to prevent T cell dysfunction in tumors
      Courtney A. 2026 Sep 21;
    • Journal Article
      Characterization of a Cytokine-Independent STAT5 Activator
      Aleck GA, Jin Y, Gu Z, Courtney AH. Biomedicines, 2026 May 1; 14 (5): DOI:10.3390/biomedicines14051097
    • Journal Article
      Immunocompetent Murine Models Recapitulate the Heterogeneous Tumor-Immune Microenvironment of Human Liposarcoma
      Shafer AM, Kenna E, Golden LAF, Elhossiny AM, Perry KD, Wilkowski J, Yan W, Kaczkofsky B, McGue J, Bresler SC, Courtney AH, Dalman JM, Galbán CJ, Jiang W, Espinoza CE, Chugh R, Iyer MK, Frankel TL, Magliano MPD, Dlugosz AA, Angeles CV. Clinical Cancer Research, 2025 Dec 1; 31 (23): 5078 - 5095. DOI:10.1158/1078-0432.CCR-25-1628
      PMID: 40928975
    • Journal Article
      Liver Metastases License Neutrophils through IL1 to Potentiate Cancer Progression
      Pearson AN, Waninger J, Huber AK, Holcomb EA, James JG, Kyi J, Elaimy AL, Wang Z, Lasse-Opsahl EL, SenGupta S, Elliott DA, Choi E, Zhang Q, Morgan MA, Chang DT, Lawrence TS, Courtney A, Shah YM, Knight JS, Di Magliano MP, Yoo S, Crivelli S, Parent CA, Ramnath N, Bryant AK, Zou W, Green MD. Cancer Immunology Research, 2025 Dec 1; 13 (12): 2023 - 2036. DOI:10.1158/2326-6066.CIR-24-1074
      PMID: 40906822

    Featured News & Stories

         cancer cell drawing in blue ink on off white background with floating yellow dots two of them
    Health Lab

    Researchers engineer a herpes virus to turn on T cells for immunotherapy

    The University of Michigan team identified herpesvirus saimiri, which infects the T cells of squirrel monkeys, as a source of proteins that activate pathways in T cells that are needed to promote T cell survival.