Yue Zhao, PhD
Research Assistant Professor
Computational Medicine and Bioinformatics
Medical School
[email protected]
Available to mentor
Yue Zhao, PhD
Research Assistant Professor
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Research Overview
My research focuses on developing and applying statistical methods for high-dimensional data integration in biomedical research. I have collaborated with basic science researchers and physicians to design optimal multi-omics data collection and perform advanced analyses, such as genomics, transcriptomics, proteomics, metabolomics, CRISPR-based genetic screening, and third-generation sequencing. My research goals include investigating the effects of environmental exposures on genome, epigenome, transcriptome, and epi-transcriptome in neurodegenerative diseases like ALS, as well as conducting multi-omics analysis to establish connections between exposures, omics, and disease risk.
Recent Publications
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Zhao Y, Savelieff MG, Li X, Guo K, Wang K, Li M, Li B, Iyer G, Sakowski SA, Zhao L, Teener SJ, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Hur J, Goutman SA, Sartor MA, Feldman EL. Nature Communications, 2025 Dec 1; 16 (1):Journal ArticleGene expression signatures from whole blood predict amyotrophic lateral sclerosis case status and survival
DOI:10.1038/s41467-025-64622-5 PMID: 41173979 -
Zhang Q, Peng J, Zhang Y, Liu J, He D, Zhao Y, Wang X, Li C, Kong Y, Wang R, Mao F, Wang C, Wang Q, Zhang M, Wang J, Yang HS, Liu X. Science Signaling, 2025 Mar 18; 18 (878):Journal ArticleThe kinase PLK1 promotes Hedgehog signaling–dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer
DOI:10.1126/scisignal.adi5174 PMID: 40100956 -
Li H, Wang D, Gao Q, Tan P, Wang Y, Cai X, Li A, Zhao Y, Thurman AL, Malekpour SA, Zhang Y, Sala R, Cipriano A, Wei CL, Sebastiano V, Song C, Zhang NR, Au KF. Nature Biotechnology, 2025 Jan 1;Journal ArticleImproving gene isoform quantification with miniQuant
DOI:10.1038/s41587-025-02633-9 -
Zhao Y, Li X, Wang K, Iyer G, Sakowski SA, Zhao L, Teener S, Bakulski KM, Dou JF, Traynor BJ, Karnovsky A, Batterman SA, Feldman EL, Sartor MA, Goutman SA. Ebiomedicine, 2024 Nov 1; 109:Journal ArticleEpigenetic age acceleration is associated with occupational exposures, sex, and survival in amyotrophic lateral sclerosis
DOI:10.1016/j.ebiom.2024.105383 PMID: 39369616 -
Gökbaǧ B, Tang S, Fan K, Cheng L, Yu L, Zhao Y, Li L. Nucleic Acids Research, 2024 Jan 5; 52 (D1): D1418 - D1428.Journal ArticleSLKB: synthetic lethality kno wledg e base
DOI:10.1093/nar/gkad806 PMID: 37889037 -
Bhayana S, Zhao Y, Merchant M, Cummins T, Dougherty JA, Kamigaki Y, Pathmasiri W, McRitchie S, Mariani LH, Sumner S, Klein JB, Li L, Smoyer WE, Mahan J, Patel H, Ransom RF, Pan C, Geary DF, Chang ML, Gibson KL, Iorember FM, Brophy PD, Srivastava T, Greenbaum LA. Kidney International Reports, 2023 Jun 1; 8 (6): 1239 - 1254.Journal ArticleMultiomics Analysis of Plasma Proteomics and Metabolomics of Steroid Resistance in Childhood Nephrotic Syndrome Using a “Patient-Specific” Approach
DOI:10.1016/j.ekir.2023.03.015 -
Liu J, Zhao Y, He D, Jones KM, Tang S, Allison DB, Zhang Y, Chen J, Zhang Q, Wang X, Li C, Wang C, Li L, Liu X. Cell Reports Medicine, 2023 Apr 18; 4 (4):Journal ArticleA kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
DOI:10.1016/j.xcrm.2023.101015 PMID: 37075701 -
Zhao Y, Yu L, Wu X, Li H, Coombes KR, Au KF, Cheng L, Li L. Bioinformatics, 2022 Dec 1; 38 (23): 5245 - 5252.Journal ArticleCEDA: integrating gene expression data with CRISPR-pooled screen data identifies essential genes with higher expression
DOI:10.1093/bioinformatics/btac668 PMID: 36250792
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Researchers develop models to help diagnose ALS earlier through blood biomarkers
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