Akira Ono, PhD
Professor
[email protected]

Available to mentor

Akira Ono, PhD
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus).

    Links
    • Ono Lab
    Qualifications
    • visiting fellow
      National Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, 2000
    • postdoctoral fellow
      National Institute of Health (Japan), Japan, 1996
    • PhD
      University of Tokyo, Tokyo, 1994
    • MS
      University of Tokyo, Tokyo, 1991
    • BS
      Waseda University, Tokyo, 1989
    Center Memberships
    • Center Member
      Global REACH
    Research Overview

    My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus). Current major areas of research in my laboratory are:
    i) molecular mechanisms that determine the sites of virus assembly,
    ii) relationships among virus assembly, plasma membrane microdomains, and cortical actin cytoskeletons,
    iii) roles played by cell polarity and virus morphology in virus spread,
    iv) incorporation of host plasma membrane proteins into nascent virus particles and their effects on virus spread, and
    v) roles played by macropinocytosis in virus entry.

    Recent Publications See All Publications
    • Presentation
      Invited Talk, "The roles Gag plays in HIV-1 particle assembly and subsequent steps"
      2023 Dec 1;
    • Presentation
      Invited State-of-the-Art Talk "The roles played by the plasma membrane components in HIV-1 assembly and beyond"
      2022 Oct 1;
    • Journal Article
      The Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes
      de Souza Cardoso R, Ono A. Viruses, 16 (11): 1714 DOI:10.3390/v16111714
    • Preprint
      PIP2 promotes the incorporation of CD43, PSGL-1 and CD44 into nascent HIV-1 particles.
      de Souza Cardoso R, Murakami T, Jacobovitz B, Veatch SL, Ono A. 2024 Sep 5; DOI:10.1101/2024.09.05.611432
      PMID: 39282414
    • Journal Article
      iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection.
      Hill BD, Zak AJ, Raja S, Bugada LF, Rizvi SM, Roslan SB, Nguyen HN, Chen J, Jiang H, Ono A, Goldstein DR, Wen F. JCI Insight, 2024 May 30; 9 (12): DOI:10.1172/jci.insight.172140
      PMID: 38814732
    • Presentation
      Seminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
      2024 Apr 19;
    • Presentation
      Seminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread"
      2024 Apr 3;
    • Journal Article
      The "basics" of HIV-1 assembly.
      Sumner C, Ono A. PLoS Pathog, 2024 Feb; 20 (2): e1011937 DOI:10.1371/journal.ppat.1011937
      PMID: 38300900
    Featured News & Stories
    Department News
    Meet Vicky Wang, an undergraduate student in Dr. Akira Ono’s lab
    Meet Vicky Wang, an undergraduate student in Dr. Akira Ono’s lab