Available to mentor
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus).
Ono Lab
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visiting fellowNational Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, 2000
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postdoctoral fellowNational Institute of Health (Japan), Japan, 1996
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PhDUniversity of Tokyo, Tokyo, 1994
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MSUniversity of Tokyo, Tokyo, 1991
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BSWaseda University, Tokyo, 1989
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Center MemberGlobal REACH
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus). Current major areas of research in my laboratory are:
i) molecular mechanisms that determine the sites of virus assembly,
ii) relationships among virus assembly, plasma membrane microdomains, and cortical actin cytoskeletons,
iii) roles played by cell polarity and virus morphology in virus spread,
iv) incorporation of host plasma membrane proteins into nascent virus particles and their effects on virus spread, and
v) roles played by macropinocytosis in virus entry.
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2023 Dec 1;PresentationInvited Talk, "The roles Gag plays in HIV-1 particle assembly and subsequent steps"
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2022 Oct 1;PresentationInvited State-of-the-Art Talk "The roles played by the plasma membrane components in HIV-1 assembly and beyond"
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de Souza Cardoso R, Ono A. Viruses, 16 (11): 1714Journal ArticleThe Effects of Viral Structural Proteins on Acidic Phospholipids in Host Membranes
DOI:10.3390/v16111714 -
de Souza Cardoso R, Murakami T, Jacobovitz B, Veatch SL, Ono A. 2024 Sep 5;PreprintPIP2 promotes the incorporation of CD43, PSGL-1 and CD44 into nascent HIV-1 particles.
DOI:10.1101/2024.09.05.611432 PMID: 39282414 -
Hill BD, Zak AJ, Raja S, Bugada LF, Rizvi SM, Roslan SB, Nguyen HN, Chen J, Jiang H, Ono A, Goldstein DR, Wen F. JCI Insight, 2024 May 30; 9 (12):Journal ArticleiGATE analysis improves the interpretability of single-cell immune landscape of influenza infection.
DOI:10.1172/jci.insight.172140 PMID: 38814732 -
2024 Apr 19;PresentationSeminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread" (scheduled)
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2024 Apr 3;PresentationSeminar "The molecular mechanisms that determine the site of HIV-1 particle assembly and the efficiency of virus spread"
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Sumner C, Ono A. PLoS Pathog, 2024 Feb; 20 (2): e1011937Journal ArticleThe "basics" of HIV-1 assembly.
DOI:10.1371/journal.ppat.1011937 PMID: 38300900