Akira Ono, PhD
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About
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus).
Links
Ono Lab
Qualifications
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visiting fellowNational Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, Bethesda, United States
1996 - 2000
Postdoctoral Fellowship
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postdoctoral fellowNational Institute of Health (Japan), Japan
1994 - 1996
Postdoctoral Research
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PhDUniversity of Tokyo, Tokyo, Japan
1991 - 1994
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MSUniversity of Tokyo, Tokyo, Japan
1989 - 1991
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BSWaseda University, Tokyo, Japan
1985 - 1989
Center Memberships
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Center MemberGlobal REACH
Research Overview
My lab is interested in the relationships between virus life cycle and cellular structures. In particular, our research focuses on roles played by cellular membranes during replication and spread of retroviruses (e.g., HIV-1) and orthomyxoviruses (e.g., influenza A virus). Current major areas of research in my laboratory are:
i) molecular mechanisms that determine the sites of virus assembly,
ii) relationships among virus assembly, plasma membrane microdomains, and cortical actin cytoskeletons,
iii) roles played by cell polarity and virus morphology in virus spread,
iv) incorporation of host plasma membrane proteins into nascent virus particles and their effects on virus spread, and
v) roles played by macropinocytosis in virus entry.
Recent Publications
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2026 Jan 28;PresentationInvited Symposium Talk "Wolfgang (Bill) Joklik Lecture: Assembly at the Plasma Membrane: What’s in the Envelope can Change Your Fate"
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Mahmoud RM, Hiyoshi M, Abdelnaser RA, Monde K, Monde N, Koma T, Mizuno H, Habash SA, Takahashi N, Maeda Y, Ono A, Suzu S. Plos Pathogens, 2026 Jun 1; 22 (6 June):Journal ArticleM-Sec promotes the production of infectious HIV-1 virus through the exocyst complex in macrophages
DOI:10.1371/journal.ppat.1013717 PMID: 42224353 -
Ono A. 2026 Apr 16;PresentationSeminar "HIV-1 Assembly and Spread — Roles Played by Plasma Membrane Acidic Phospholipids and tRNAs"
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Mahmoud RM, Hiyoshi M, Abdelnaser RA, Monde K, Monde N, Koma T, Mizuno H, Habash SA, Takahashi N, Maeda Y, Ono A, Suzu S. bioRxiv, 2025 Nov 13;Journal ArticleM-Sec promotes the production of infectious HIV-1 virus through the exocyst complex.
DOI:10.1101/2025.11.13.688207 PMID: PMC12642479 -
Abdelnaser RA, Hiyoshi M, Takahashi N, Kimura S, Hase K, Ohno H, Monde K, Ono A, Suzu S. Journal of Leukocyte Biology, 2025 Nov 1; 117 (11):Journal ArticleTNFAIP2 increases macrophage response to CSF-1 through multiple effects on CSF-1 receptor
DOI:10.1093/jleuko/qiaf151 PMID: 41158107 -
Koma T, Kotani O, Kamba K, Miyakawa K, Morita T, Nakamura H, Yokoyama M, Doi N, Kondo T, Nagata T, Ryo A, Adachi A, Ono A, Katahira M, Nomaguchi M, Sato H. Journal of Virology, 2025 Oct 1; 99 (10):Journal ArticlePositive correlation between structural disorder of the HIV-1 Gag N-terminal segment and progeny virus particle formation
DOI:10.1128/jvi.00887-25 PMID: 40956082 -
2026 Jan 28;PresentationInvited Talk "Phosphatidylinositol (4,5)-bisphosphate promotes incorporation of host transmembrane proteins and Env into HIV-1 particles"
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de Souza Cardoso R, Ono A. 2025 Sep 16;Proceeding / Abstract / PosterPhosphatidylinositol (4,5)-bisphosphate promotes incorporation of host transmembrane proteins and Env into HIV-1 particles
