Eileen S Carpenter, MD, PhD

 carpenter-eileen
Assistant Professor of Internal Medicine, Medical School
Office:
University of Michigan–Ann Arbor
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Email:
[email protected]
Available to mentor
Eileen S Carpenter, MD, PhD
carpenter-eileen
Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Eileen received her undergraduate chemical engineering degree from the Cooper Union and her combined MD/PhD from SUNY Stony Brook University through the Medical Scientist Training Program. She then joined the University of Michigan and completed her internal medicine residency and gastroenterology fellowship through their fast-track research pathway. She recently joined faculty at the University of Michigan and has an appointment at the University of Michigan affiliate, VA Ann Arbor Healthcare System. Her clinical practice is focused on treating patients with benign and malignant diseases of the pancreas. In her free time, she enjoys taking care of her three kids, playing the piano, volunteering at church, /and serving on the local Little League board.

    Qualifications
    • Fellowship
      University of Michigan, Internal Medicine, Gastroenterology, Ann Arbor, United States
      2017 - 2020
      Clinical Fellowship
    • Residency
      University of Michigan, Internal Medicine, Ann Arbor, Michigan, United States
      2015 - 2017
      Residency

    Center Memberships
    • Center Member
      Rogel Cancer Center

    Research Overview

    Dr. Carpenter’s recent research accomplishments include establishing a pipeline using endoscopic fine needle biopsies of pancreatic tumors for a wide variety of techniques, including single-cell RNA sequencing, mass cytometry, and organoid culture. The Carpenter lab is currently focused on extending existing pipelines to study chemoresistance using longitudinal matched samples in patients pre- and post-chemotherapy, with the goal of identifying new immunotherapeutic targets to overcome chemo-refractory disease in pancreatic ductal adenocarcinoma.

    Recent Publications

     See All Publications
    • Presentation
      Exploring the Neural Niche in Pancreatic Cancer
      Carpenter E. 2026 Oct 14;
    • Journal Article
      Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer
      Elhossiny AM, Kadiyala P, Okoye JO, Hiraki HL, Procario MC, Giridharan T, Watkoske HR, Tannus Ruckert M, Wang J, Griffith BD, Bray AW, Mills JN, Espinoza CE, Zeller J, Peterson N, Bednar F, Zhang Y, Rao A, Lyssiotis CA, Szczepanski JM, Shi J, Deshpande A, Maitra A, Fertig EJ, Carpenter ES, Frankel TL, Pasca Di Magliano M. Cancer Discovery, 2026 Oct 1; 16 (10): 2060 - 2084. DOI:10.1158/2159-8290.CD-25-2001
      PMID: 42165710
    • Proceeding / Abstract / Poster
      Abstract B003: Developing an all-human model of perineural invasion in pancreatic cancer
      Casimiro-Núñez RA, Willey S, Hiraki H, Henstridge AZ, Azorsa PA, Goldwasser M, Koenig F, Sahai V, Peterson N, Machicado JD, Kwon R, Schulman AR, Wamsteker E, Philips G, Menees SB, Xia JY, Rao A, Shi J, Saadeh Y, Szerlip N, Biesterveld B, Frankel TL, Bednar F, Pasca di Magliano M, Callaghan B, Todd PK, Carpenter ES. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b003 - b003. DOI:10.1158/1538-7445.pancreatic26-b003
    • Proceeding / Abstract / Poster
      Abstract B078: Developing an all-human preclinical model of PDAC immunoreactivity
      Azorsa PA, Goldwasser M, Sahai V, Peterson N, Machicado JD, Kwon R, Schulman AR, Phillips G, Menees SB, Wamsteker E, Xia JY, Shi J, Frankel TL, Bednar F, Di Magliano MP, Carty S, Carpenter ES. Cancer Research, 2026 Sep 27; 86 (18_Supplement_2): b078 - b078. DOI:10.1158/1538-7445.pancreatic26-b078
    • Presentation
      Wired for innervation: Modeling the neural niche in pancreatic cancer
      Carpenter E. 2026 Jun 16;
    • Journal Article
      Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer.
      Henstridge AZ, Azorsa PA, Arya N, Elhossiny AM, Kadiyala P, Goldwasser M, Branch G, Sahai V, Peterson N, Machicado JD, Kwon RS, Schulman AR, Wamsteker E-J, Philips GM, Menees SB, Xia JY, Hogenson TL, Rao A, Shi J, Frankel TL, Bednar F, Pasca di Magliano M, Lyssiotis CA, Truty MJ, Fernandez-Zapico ME, Carpenter ES. Cancer Res, 2026 Sep 29; DOI:10.1158/0008-5472.CAN-26-0823
    • Journal Article
      Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer.
      Zhang Y, Kadiyala P, Yan W, Brown K, Avritt FR, Donahue KL, Procario MC, Okoye JO, Giridharan T, Elhossiny AM, Espinoza CE, Awad D, Lasse Opsahl EL, Medina-Cabrera PI, Velez-Delgado A, Menjivar RE, Yang OA, Yang S, He X, Gupta S, Tariq R, Brandt AR, Wang X, denDekker A, Nwosu ZC, Carpenter ES, Courtney AH, Bednar F, Frankel TL, Lyssiotis CA, Zheng B, Kryczek I, Pasca Di Magliano M. Cancer Immunol Res, 2026 Jun 2; DOI:10.1158/2326-6066.CIR-25-1300
    • Proceeding / Abstract / Poster
      296b LONGITUDINAL ANALYSIS OF MATCHED PATIENT BIOSPECIMENS REVEALS NEURAL REPROGRAMMING OF CANCER-ASSOCIATED FIBROBLASTS FOLLOWING CHEMOTHERAPY IN PANCREATIC DUCTAL ADENOCARCINOMA
      Henstridge A, Sahai V, Peterson N, Machicado JD, Kwon R, Schulman AR, Wamsteker E-J, Philips GM, Menees SB, Xia JY, Hogenson T, Shi J, Frankel T, Bednar F, Di Magliano MP, Lyssiotis CA, Truty MJ, Fernandez-Zapico ME, Carpenter E. Gastrointestinal Endoscopy, 2026 May 3; 103 (5): s - 2850. DOI:10.1016/s0016-5107(26)06672-1

    Featured News & Stories
    Illuminate

    Tackling Pancreatic Cancer, Bench to Bedside

    Learn how Dr. Eileen Carpenter's translational research laboratory studies pancreatic cancer at the molecular level—how it develops, metastasizes and becomes resistant to therapy. The goal is to identify new therapeutic targets and strategies to overcome chemoresistance so patients may live longer, healthier lives.
    Department News

    New Publication by Carpenter, ElHossiny and Kadiyala (Pasca di Magliano Lab)

    A new Publication by Carpenter, ElHossiny and Kadiyala (Pasca di Magliano Lab) was published in Cancer Discovery.
         A scientific diagram of immunofluoresence
    Department News

    Donor pancreas tissue helps define ‘new normal’ in pancreatic cancer research

    A research partnership between Michigan Medicine and Gift of Life Michigan has revealed a new pathway to understanding the progression of pancreatic cancer.