Santhi K Ganesh
David J Pinsky M.D. Professor in Cardiovascular Medicine
Professor of Internal Medicine
Professor of Human Genetics and Program Director, Internal Medicine
[email protected]

Available to mentor

Santhi K Ganesh
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Ganesh is Professor (with tenure) of Internal Medicine and Professor of Human Genetics where she is jointly appointed. Her clinical work is in the Division of Cardiovascular Medicine and Section of Vascular Medicine, focused on the evaluation and care of patients with cardiovascular diseases and potential genetic disorders. Dr. Ganesh runs an independent research laboratory as Principal Investigator with extramural funding from NIH and other foundations and professional organizations. The laboratory is working to define the genetic basis of cardiovascular diseases and study these genetic effects in model systems, bringing together trainees from all levels and faculty from diverse clinical and scientific backgrounds. Dr. Ganesh has published over 130 scientific papers in high impact journals. Her contributions include the discovery of clinically actionable gene findings and understanding of new biology underlying several vascular diseases, including fibromuscular dysplasia, spontaneous coronary artery dissection., and hypertensive disorders. As a testament to her impact in the field, she has received numerous awards and honorifics. She is the inaugural David J. Pinsky Endowed Professor of Cardiovascular Medicine at the University of Michigan, and has received awards from the American Heart Association, Doris Duke Charitable Foundation, and National Institutes of Health. She serves as the Director for the M-BRISC initiative at the University of Michigan Cardiovascular Center focused on understanding sex differences of cardiovascular diseases. She is a distinguished teacher and mentor, and collaborates effectively across disciplines.

    Qualifications
    • Postdoctoral fellowship
      National Institutes of Health, NHLBI and NHGRI
    • Postdoctoral fellowship
      Johns Hopkins Institute of Genetic Medicine, Baltmore
    • Internal Medicine Residency
      University of Michigan, USA
    • Cardiology Fellowship
      Johns Hopkins School of Medicine, USA
    • MD
      Northwestern University Feinberg School of Medicine, Chicago
    • BA
      Northwestern University, Chicago
    Center Memberships
    • Center Member
      Precision Health Initiative
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Taubman Institute
    Research Overview

    The Ganesh Laboratory is working to understand the genetic basis of vascular diseases. The lab uses computational approaches to discovery genetic drivers of disease, and fundamental bench research to model genetic effects and understand mechanisms of disease so that new therapies may be developed. Disease areas include poorly understood and rare diseases such as fibromuscular dysplasia, spontaneous coronary artery dissections, and midaortic syndrome., as well as more common problems such as hypertension, including hypertensive disorders of pregnancy.
    Please visit www.ganeshlab.org for more information.

    Recent Publications See All Publications
    • Journal Article
      Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.
      Yaacov O, Mathiyalagan P, Berk-Rauch HE, Ganesh SK, Zhu L, Hoffmann TJ, Iribarren C, Risch N, Lee D, Chakravarti A. Hypertension, 2024 May 15; DOI:10.1161/HYPERTENSIONAHA.123.22538
      PMID: 38747164
    • Journal Article
      Sex-specific genetic architecture of blood pressure.
      Yang M-L, Xu C, Gupte T, Hoffmann TJ, Iribarren C, Zhou X, Ganesh SK. Nat Med, 2024 Mar; 30 (3): 818 - 828. DOI:10.1038/s41591-024-02858-2
      PMID: 38459180
    • Preprint
      Coordination between cytoskeletal organization, cell contraction and extracellular matrix development, is depended on LOX for aneurysm prevention.
      Aviram R, Zaffryar-Eilot S, Kaganovsky A, Odeh A, Melamed S, Militsin R, Pinnock CB, Shemesh A, Palty R, Ganesh SK, Hasson P. 2024 Feb 29; DOI:10.1101/2024.02.23.581837
      PMID: 38464309
    • Proceeding / Abstract / Poster
      5 Peripartum dapagliflozin improves late life cardiovascular outcomes in a mouse model of superimposed preeclampsia
      Hesson A, Sangtani A, Langen ES, Hunker K, Kumar N, Ganesh SK. American Journal of Obstetrics and Gynecology, 2024 Jan; 230 (1): s4 DOI:10.1016/j.ajog.2023.11.019
    • Preprint
      Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressure
      Yaacov O, Mathiyalagan P, Berk-Rauch HH, Ganesh SK, Zhu L, Hoffmann TJ, Iribarren C, Risch N, Lee D, Chakravarti A. medRxiv, DOI:10.1101/2023.12.07.23299084
    • Journal Article
      Advancements in the Genetics of Spontaneous Coronary Artery Dissection.
      Katz AE, Ganesh SK. Curr Cardiol Rep, 2023 Dec; 25 (12): 1735 - 1743. DOI:10.1007/s11886-023-01989-1
      PMID: 37979122
    • Journal Article
      Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension.
      Hesson AM, Langen ES, Plazyo O, Gudjonsson JE, Ganesh SK. BMC Med Genomics, 2023 May 2; 16 (1): 91 DOI:10.1186/s12920-023-01522-x
      PMID: 37131171
    • Journal Article
      Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure.
      Lee D, Han SK, Yaacov O, Berk-Rauch H, Mathiyalagan P, Ganesh SK, Chakravarti A. Cell Rep, 2023 Nov 28; 42 (11): 113351 DOI:10.1016/j.celrep.2023.113351
      PMID: 37910504