Alison Holley Affinati
Assistant Professor
Department of Internal Medicine, Division of Endocrinology
2800 Plymouth Rd, Building 25-3700
Ann Arbor, United States
[email protected]

Available to mentor
Alison Holley Affinati
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    Qualifications
    • Post-doctoral research fellow, Laboratory of Dr. Martin Myers
      University of Michigan Medical School, Ann Arbor, 2021
    • Endocrinology Fellowship Program
      University of Michigan–Ann Arbor, Ann Arbor, 2020
    • Internal Medicine Residency Program
      University of Michigan–Ann Arbor, Ann Arbor, 2017
    • MD, PhD
      Northwestern Feinberg School of Medicine, 2015
    • B.S.
      University of Chicago, 2007
    • B.S.
      Boston University, 2005
    Center Memberships
    • Center Member
      Taubman Institute
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    I study how the central nervous system regulates glucose homeostasis, with a specific focus on the role of the ventromedial hypothalamus in glucose and energy metabolism.

    Recent Publications See All Publications
    • Presentation
      Mapping the Neural Circuits that Drive Stress-Induced Hyperglycemia
      Affinati A. 2025 Apr 17;
    • Proceeding / Abstract / Poster
      Stressed Out: Glucose and Glipr1 – expressing neurons as keys to uncovering the neurocircuitry that controls stress-induced hyperglycemia
      Wloszek J, Mancuso A, Su J, Robichaud P, Affinati A. 2025 Apr 14;
    • Journal Article
      Leptin activates dopamine and GABA neurons in the substantia nigra via a local pars compacta-pars reticulata circuit.
      Mancini M, Hikima T, Witkovsky P, Patel JC, Stone DW, Affinati AH, Rice ME. J Neurosci, 2025 Mar 24; DOI:10.1523/JNEUROSCI.1539-24.2025
      PMID: 40127936
    • Presentation
      Neural Circuits that Control Physiologic Glucose Homeostasis
      Affinati A. 2025 Mar 5;
    • Presentation
      Targeting Neural Circuits to Optimize Glucose Control
      Affinati A. 2024 Nov 21;
    • Presentation
      A Hypothlamic-Adipose-Liver Axis for Glucose Mobilization
      Affinati A. 2024 Sep 17;
    • Proceeding / Abstract / Poster
      Disentangling the neural circuits that drive diabetes
      Affinati A. 2024 Jul 28;
    • Presentation
      Hypothalamic Control of Metabolism: Modulating Gluconeogenic Substrate Availability to Maintain Glucose Homeostasis
      Affinati A. 2024 Jul 11;