Alison Holley Affinati
Assistant Professor of Internal Medicine
Department of Internal Medicine, Division of Endocrinology
2800 Plymouth Rd, Building 25-3700
Ann Arbor, United States
[email protected]

Available to mentor
Alison Holley Affinati
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • Post-doctoral research fellow, Laboratory of Dr. Martin Myers
      University of Michigan Medical School, Ann Arbor, 2021
    • Endocrinology Fellowship Program
      University of Michigan–Ann Arbor, Ann Arbor, 2020
    • Internal Medicine Residency Program
      University of Michigan–Ann Arbor, Ann Arbor, 2017
    • B.S.
      Boston University, Boston, 2005
    Center Memberships
    • Center Member
      Taubman Institute
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    I study how the central nervous system regulates glucose homeostasis, with a specific focus on the role of the ventromedial hypothalamus in glucose and energy metabolism.

    Recent Publications See All Publications
    • Journal Article
      Peak insulin drip rate associated with decreased infections post-solid organ transplant.
      Upadrasta G, Affinati A, Kumar S, Zelada H, Fulkerson C, Gupta S, Pollack T, Andrei A-C, Oakes DJ, Schmidt K, Therasse A, Grady K, Pham D, Wilcox J, Levitsky J, Parikh N, Ladner D, Aleppo G, Molitch ME, Wallia A. Clin Transplant, 2024 Jan; 38 (1): e15239 DOI:10.1111/ctr.15239
      PMID: 38289889
    • Journal Article
      Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
      Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG. J Clin Invest, 2023 Oct 2; 133 (19): DOI:10.1172/JCI157515
      PMID: 37581939
    • Chapter
      Brain Regulation of Feeding and Energy Homeostasis
      Affinati AH, Elias CF, Olson DP, Myers MG. 2023 Metabolic Syndrome, 1 - 19. DOI:10.1007/978-3-319-12125-3_22-2
    • Chapter
      Brain Regulation of Feeding and Energy Homeostasis
      Affinati AH, Elias CF, Olson DP, Myers MG. 2023 Metabolic Syndrome, 283 - 301. DOI:10.1007/978-3-031-40116-9_22
    • Journal Article
      Leptin promotes striatal dopamine release via cholinergic interneurons and regionally distinct signaling pathways.
      Mancini M, Patel JC, Affinati AH, Witkovsky P, Rice ME. J Neurosci, 2022 Jul 20; 42 (35): 6668 - 6679. DOI:10.1523/JNEUROSCI.0238-22.2022
      PMID: 35906070
    • Journal Article
      This Week in The Journal
      Mancini M, Patel JC, Affinati AH, Witkovsky P, Rice ME. Journal of Neuroscience, 2022 Aug 31; 42 (35): 6667 DOI:10.1523/JNEUROSCI.twij.42.35.2022
    • Journal Article
      153-OR: Ventromedial Hypothalamic Nucleus Controls Glucose Metabolism through Adipose Tissue Lipolysis
      AFFINATI A, FLAK J, KODUR N, HASHSHAM A, TOMLINSON AJ, KRAMER NB, LI C, MYERS MG. Diabetes, 2022 Jun 1; 71 (Supplement_1): DOI:10.2337/db22-153-or
    • Journal Article
      Immune Checkpoint Inhibitors and Risk of Type 1 Diabetes.
      Chen X, Affinati AH, Lee Y, Turcu AF, Henry NL, Schiopu E, Qin A, Othus M, Clauw D, Ramnath N, Zhao L. Diabetes Care, 2022 May 1; 45 (5): 1170 - 1176. DOI:10.2337/dc21-2213
      PMID: 35238899