Professor of Internal Medicine
Professor of Microbiology and Immunology
Professor of Ecology and Evolutionary Biology
College of Literature, Science, and the Arts
[email protected]
Available to mentor
Adam Lauring, MD, PhD
Professor
Dr. Lauring is a physician-scientist with a research interest in the genetics and evolution of RNA viruses
Lauring Lab
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MDUniversity of Washington, Seattle, 2002
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PhDUniversity of Washington, Seattle, 2000
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BSYale University, New Haven, 1994
Dr. Lauring’s laboratory has worked in three main areas. First, they study the importance of mutation rate and mutational tolerance to the evolution of poliovirus and influenza virus. More recently, they have utilized next generation sequencing of patient samples to define the within-host evolution and transmission of influenza virus, poliovirus, and SARS-CoV-2. Since the beginning of the COVID pandemic, his laboratory has collaborated with large teams to study the genomic epidemiology of respiratory viruses and the effectiveness of vaccines against them.
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Lewis NM, Harker EJ, Leis A, Zhu Y, Talbot HK, Grijalva CG, Halasa N, Chappell JD, Johnson CA, Rice TW, Casey JD, Lauring AS, Gaglani M, Ghamande S, Columbus C, Steingrub JS, Shapiro NI, Duggal A, Felzer J, Prekker ME, Peltan ID, Brown SM, Hager DN, Gong MN, Mohamed A, Exline MC, Khan A, Wilson JG, Mosier J, Qadir N, Chang SY, Ginde AA, Mohr NM, Mallow C, Harris ES, Johnson NJ, Srinivasan V, Gibbs KW, Kwon JH, Vaughn IA, Ramesh M, Safdar B, DeCuir J, Surie D, Dawood FS, Ellington S, Self WH, Martin ET. Vaccine, 2024 Nov 7; 43 (Pt 2): 126492Journal ArticleAssessment and mitigation of bias in influenza and COVID-19 vaccine effectiveness analyses - IVY Network, September 1, 2022-March 30, 2023.
DOI:10.1016/j.vaccine.2024.126492 PMID: 39515195 -
DeCuir J, Surie D, Zhu Y, Lauring AS, Gaglani M, McNeal T, Ghamande S, Peltan ID, Brown SM, Ginde AA, Steinwand A, Mohr NM, Gibbs KW, Hager DN, Ali H, Frosch A, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Khan A, Busse LW, Duggal A, Wilson JG, Qadir N, Chang SY, Mallow C, Kwon JH, Exline MC, Shapiro NI, Columbus C, Vaughn IA, Ramesh M, Safdar B, Mosier JM, Casey JD, Talbot HK, Rice TW, Halasa N, Chappell JD, Grijalva CG, Baughman A, Womack KN, Rhoads JP, Swan SA, Johnson C, Lewis N, Ellington S, Dawood FS, McMorrow M, Self WH, Investigating Respiratory Viruses in the Acutely Ill (IVY) Network . Influenza Other Respir Viruses, 2024 Nov; 18 (11): e70027Journal ArticleEffectiveness of Original Monovalent and Bivalent COVID-19 Vaccines Against COVID-19-Associated Hospitalization and Severe In-Hospital Outcomes Among Adults in the United States, September 2022-August 2023.
DOI:10.1111/irv.70027 PMID: 39496339 -
Hager DN, Zhu Y, Sohn I, Stubblefield WB, Streiff MB, Gaglani M, Steingrub JS, Duggal A, Felzer JR, O'Rourke M, Peltan ID, Mohamed A, Stiller R, Wilson JG, Qadir N, Ginde AA, Zepeski AE, Mallow C, Lauring AS, Johnson NJ, Gibbs KW, Kwon JH, Self WH, Investigating Respiratory Viruses in the Acutely Ill (IVY) Network . J Infect Dis, 2024 Oct 15;Journal ArticleEffectiveness of the original monovalent mRNA COVID-19 vaccination series against hospitalization for COVID-19-associated venous thromboembolism.
DOI:10.1093/infdis/jiae502 PMID: 39405261 -
Fowlkes AL, Peretz A, Greenberg D, Hirsch A, Martin ET, Levine MZ, Edwards L, Radke S, Lauring AS, Ferdinands JM, Zhang C, Yoo YM, Dreiher J, Newes-Adeyi G, Azziz-Baumgartner E, Fry AM, Monto AS, Balicer R, Thompson MG, Katz MA. Int J Infect Dis, 2024 Oct 10; 149: 107260Journal ArticleRandomised immunogenicity trial comparing 2019-2020 recombinant and egg-based influenza vaccines among frequently vaccinated healthcare personnel in Israel.
DOI:10.1016/j.ijid.2024.107260 PMID: 39395753 -
Olp MD, Laufer VA, Valesano AL, Zimmerman A, Woodside KJ, Lu Y, Lauring AS, Cusick MF. Life (Basel), 2024 Sep 19; 14 (9):Journal ArticleHLA-C Peptide Repertoires as Predictors of Clinical Response during Early SARS-CoV-2 Infection.
DOI:10.3390/life14091181 PMID: 39337964 -
Olp M, Laufer V, Valesano A, Zimmerman A, Woodside K, Najor M, Lu Y, Lauring A, Cusick M. Human Immunology, 2024 Sep; 85: 110860Journal ArticleHLA-C peptide repertoires as predictors of clinical response during early SARS-CoV-2 infection
DOI:10.1016/j.humimm.2024.110860 -
Monto AS, Foster-Tucker JE, Callear AP, Leis AM, Godonou E-T, Smith M, Truscon R, Johnson E, Thomas LJ, Thompson MS, Fry AM, Flannery B, Malosh RE, Petrie JG, Lauring AS, Martin ET. J Infect Dis, 2024 Aug 24;Journal ArticleRespiratory Viral Infections from 2015 to 2022 in the HIVE Cohort of American Households: Incidence, illness characteristics, and seasonality.
DOI:10.1093/infdis/jiae423 PMID: 39179953 -
Bendall EE, Zhu Y, Fitzsimmons WJ, Rolfes M, Mellis A, Halasa N, Martin ET, Grijalva CG, Talbot HK, Lauring AS. bioRxiv, 2024 Aug 19;Journal ArticleInfluenza A virus within-host evolution and positive selection in a densely sampled household cohort over three seasons.
DOI:10.1101/2024.08.15.608152 PMID: 39229225
Health Lab
A Michigan Medicine virologist speaks about the implications of H5N1 influenza, or bird flu, and whether a new pandemic could be on the horizon.
News Release
An $18 million National Science Foundation grant will establish a new center to bring computer science, infectious disease, engineering, and the arts together to predict and prevent global pandemics
News Release
A new NIH award will establish the Michigan Infectious Disease Genomics (MIDGE) Center, the goal of which is to use whole genome sequencing and functional genomic assays to determine how genetic differences among strains or isolates affect the behavior, transmission, and drug resistance of viral, bacterial, and fungal pathogens.
Department News
The Department of Microbiology and Immunology (M&I) celebrated 25 years of its NIH T32 training grant that supports the Molecular Mechanisms in Microbial Pathogenesis Training Program (MMMP) with a scientific symposium, held June 18, 2024.
Medical School News
Many Michigan Medicine labs are taking time to ensure that they are doing their part to support the Medical School’s major initiatives, including the push for carbon neutrality.
