Joshua Meisner, MD, PhD

 Joshua Meisner
Assistant Professor of Pediatrics
Medical School
Available to mentor
Joshua Meisner, MD, PhD
Joshua Meisner
Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Dr. Meisner is a physician-scientist in Pediatric Cardiology at the University of Michigan. His clinical focus is in cardiovascular genetics collaborating in the hypertrophic cardiomyopathy, muscular dystrophy, cardiovascular genetics and aortopathy, and RASopathy multidisciplinary clinics. He also sees general cardiology and molecular and biochemical cardiology patients in his individual clinics. His translational research laboratory utilizes induced pluripotent stem cell cardiomyocyte (iPSC CM) and innovative mouse models to understanding the of pathophysiology and clinical course that leads to cardiomyopathy in children and young adults secondary to metabolic disorders (e.g. TANGO2 related metabolic encephalopathy and arrhythmia syndrome), growth signaling (e.g. RASopathies), and disruption of the cardiomyocyte contractile apparatus (e.g. MYBPC3 hypertrophic cardiomyopathy).

    Qualifications
    • Pediatric Cardiology Fellowship
      University of Michigan, Pediatric Cardiology, Ann Arbor, United States
      2018 - 2021
      Residency
    • Pediatric Resident
      University of Michigan, Pediatrics, Ann Arbor, United States
      2015 - 2018
      Residency
    • MD, PhD, Biomedical Engineering
      University of Virginia, Charlottesville, Virginia, United States
      2006 - 2015
    • MS, Biomedical Engineering
      Texas A&M University, College Station, Texas, United States
      2005 - 2006
    • BS, Biomedical Engineering
      Texas A&M University, College Station, Texas, United States
      2000 - 2004

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center

    Research Overview

    1. Mechanisms and translational therapeutics in MYBPC3 related hypertrophic cardiomyopathy
    2. Outcomes in pediatric cardiomyopathy.
    3. TANGO2 Related Metabolic Encephalopathy and Arrhythmia
    4. Molecular guided therapies for pediatric cardiomyopathy
    5. Role of lymphatic function in congenital heart disease and protein losing enteropathy

    Recent Publications

     See All Publications
    • Proceeding / Abstract / Poster
      LONGITUDINAL AORTIC ROOT GROWTH AND OUTCOMES IN PEDIATRIC MARFAN SYNDROME COMPARED BY BASELINE DILATION STATUS: A MULTICENTER STUDY FROM CLARITY
      Bita S, Spence C, Espahbodi N, Gwin C, Stephens S, Yetman A, Tierney S, Iannucci G, Sallee D, Nees S, Jones E, Camarda J, Holmes K, Drant S, Prakash S, Tunks R, McBridge K, Renella P, Dilorenzo M, Channing A, Steele J, Milewicz D, Meisner J, Lu J, Quezada Liuti E, Niaz T, Jacob B, Dawson T, Martin-Sheehan J, Soludczyk E, Weigand J, Morris S. 2026 Oct 4;
    • Journal Article
      Targeted Anti-IL-1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L-Related Arrhythmogenic Cardiomyopathy.
      Renberg A, Coppersmith S, Merritt O, Heider A, Helms A, Michniacki T, Luxford J, Josephi-Taylor S, Roberts P, Meisner J. Am J Med Genet A, 2026 Apr 3; DOI:10.1002/ajmg.a.70156
      PMID: 41928611
    • Presentation
      Determining the Mechanical and Metabolic Pathogenesis of MYBPC3 Related Hypertrophic Cardiomyopathy
      Meisner J. 2026 May 8;
    • Proceeding / Abstract / Poster
      A Triple Diagnosis Case Illustrating the Need for Continued Re-Evaluation
      Reeves S, Sloan-Heggen C, Whitt Z, Meisner J, Ames E, Lejman M. 2026 Mar 10;
    • Proceeding / Abstract / Poster
      AAV Gene Replacement Therapy in Mybpc3 Related Hypertrophic Cardiomyopathy Mouse Model Improves Ventricular Function
      Meisner J, Bullard A, Lange J, Friedline S, Previs M, Helms A. 2026 Mar 9;
    • Journal Article
      P407: A triple diagnosis case illustrating the need for continued re-evaluation
      Reeves S, Sloan-Heggen C, Lejman M, Whitt Z, Meisner J, Ames E. Genetics in Medicine Open, 2026 Mar 7; 4: 103901 DOI:10.1016/j.gimo.2026.103901
    • Journal Article
      Preparing for Tomorrow, Today
      Russell MW, Meisner JK. Journal of the American College of Cardiology, 2026 Jan 1; DOI:10.1016/j.jacc.2026.04.007
    • Presentation
      2025 TANGO2 Virtual Research Symposium
      2025 Oct 24;