Joshua Meisner, MD, PhD

Dr. Meisner is a physician-scientist in Pediatric Cardiology at the University of Michigan. His clinical focus is in cardiovascular genetics collaborating in the hypertrophic cardiomyopathy, muscular dystrophy, cardiovascular genetics and aortopathy, and RASopathy multidisciplinary clinics. He also sees general cardiology and molecular and biochemical cardiology patients in his individual clinics. His translational research laboratory utilizes induced pluripotent stem cell cardiomyocyte (iPSC CM) and innovative mouse models to understanding the of pathophysiology and clinical course that leads to cardiomyopathy in children and young adults secondary to metabolic disorders (e.g. TANGO2 related metabolic encephalopathy and arrhythmia syndrome), growth signaling (e.g. RASopathies), and disruption of the cardiomyocyte contractile apparatus (e.g. MYBPC3 hypertrophic cardiomyopathy).

My research interests focus on optimizing the care in pediatric rare disease across the spectrum from clinical research, translational studies, and basic science on the molecular mechanics of disease across the following core pathologies:

1. The driving mechanisms and translational therapeutics in MYBPC3 related hypertrophic cardiomyopathy
2. The role of dysfunctional mitochondrial metabolism as a driver of hypertrophic pathophysiology
3. Molecularly guided therapies for RASopathies
4. TANGO2 Deficiency Disorder
5. Optimizing cellular and animal based models of pediatric onset cardiomyopathy