Nadejda Bozadjieva Kramer, PhD
Department of Surgery
2800 Plymouth Rd, NCRC B25-3688
Ann Arbor, Michigan 48109
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About
Dr. Bozadjieva Kramer’s research efforts leverage both basic and translational science towards a better understanding of the critical factors behind metabolic dysfunction. Her passion is to develop the best interventions to meet the enormous unmet needs of patients with obesity and metabolic disorders.
Dr. Bozadjieva Kramer holds research appointments in the Ann Arbor Veterans Affairs Health Systems and Michigan Medicine, Department of Surgery. She has received several funding awards, including Department of Veterans Affairs Career Development Award, University of Michigan Center for Gastrointestinal Research Pilot Award, , Michigan Institute for Clinical & Health Research Fellowship award and Michigan Nutrition and Obesity Research Center Pilot Award..
Links
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Qualifications
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Postdoctoral Research FellowUniversity of Michigan, Surgery, Ann Arbor, United States
2016 - 2022
Postdoctoral Research
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PhD, Cellular and Molecular BiologyUniversity of Michigan, Ann Arbor, United States
2011 - 2016
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MS, Integrated BiosciencesUniversity of Minnesota, Duluth, United States
2009 - 2011
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BS, Cell and Molecular BiologyUniversity of Minnesota, Duluth, United States
2005 - 2009
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberFrankel Institute for Heart and Brain Health
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Dr. Bozadjieva Kramer's overall research interests focus on the pancreas-gut-liver axis, understanding the roles enterohepatic and nutrient signaling play in obesity, comorbidities (Type 2 diabetes, MASLD, and MASH) and how these change after rapid weight loss (diet, pharmacological, or surgery-induced weight loss). These projects employ extensive metabolic techniques including surgical, molecular, pharmacological, and physiological expertise in clinical and preclinical models.
Recent Publications
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Kwon JJ, Li J, Liu JYC, Patsalis C, Wu P, Kawase YH, Ky A, Pasternak C, Mason DD, Bozadjieva-Kramer N, Loebel C, Lumeng CN, O’Rourke RW. International Journal of Molecular Sciences, 2025 Nov 1; 26 (22):Journal ArticleA Hydrogel Culture System Regulates Human Adipocyte Function
DOI:10.3390/ijms262210865 PMID: 41303352 -
Blok NB, Evers SS, Lewis AG, Toure MH, Bozadjieva-Kramer N, Seeley RJ, Myronovych A. Surgery for Obesity and Related Diseases, 2025 Nov 1; 21 (11): 1198 - 1209.Journal ArticleTowards a better mouse model of vertical sleeve gastrectomy
DOI:10.1016/j.soard.2025.06.017 PMID: 40841215 -
Blok NB, Bozadjieva-Kramer N. American Journal of Physiology Regulatory Integrative and Comparative Physiology, 2025 Aug 1; 329 (2): R326 - R328.Journal ArticleUnlocking the gut: microbiome’s role in energy metabolism
DOI:10.1152/ajpregu.00158.2025 PMID: 40637165 -
Blok NB, Myronovych A, McMahon G, Bozadjieva-Kramer N, Seeley RJ. American Journal of Physiology Endocrinology and Metabolism, 2025 Apr 1; 328 (4): E513 - E523.Journal ArticleThe evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature
DOI:10.1152/ajpendo.00401.2024 PMID: 39998384 -
Shin JH, Bozadjieva-Kramer N, Shao Y, Mercer AJ, Lyons-Abbott S, Awan RR, Lewis A, Seeley RJ. American Journal of Physiology Endocrinology and Metabolism, 2025 Mar 1; 328 (3): E447 - E456.Journal ArticleIntraduodenal administration of Reg3g improves gut barrier function and mitigates hepatic steatosis in mice
DOI:10.1152/ajpendo.00132.2024 PMID: 39970263 -
Hes C, Gui LT, Bay A, Alvarez F, Katz P, Paul T, Bozadjieva-Kramer N, Seeley RJ, Piccirillo CA, Sabatini PV. Molecular Metabolism, 2025 Jan 1; 91:Journal ArticleGDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
DOI:10.1016/j.molmet.2024.102070 PMID: 39608751 -
Wean J, Baranwal S, Miller N, Shin JH, O'Rourke RW, Burant CF, Seeley RJ, Rothberg AE, Bozadjieva-Kramer N. Diabetes and Metabolism, 2024 Sep 1; 50 (5):Journal ArticleGut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss
DOI:10.1016/j.diabet.2024.101570 PMID: 39134173 -
Bozadjieva-Kramer N, Shin JH, Blok NB, Jain C, Das NK, Polex-Wolf J, Knudsen LB, Shah YM, Seeley RJ. Endocrinology United States, 2024 Sep 1; 165 (9):Journal ArticleLiraglutide Impacts Iron Homeostasis in a Murine Model of Hereditary Hemochromatosis
DOI:10.1210/endocr/bqae090 PMID: 39045670
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