Caitlin M Oconnor
Research Assistant Professor
Internal Medicine
[email protected]

Available to mentor
Caitlin M Oconnor
Research Investigator
  • Qualifications
  • Recent Publications
    • Qualifications
    • Postdoctoral Research Fellow
      University of Michigan, Ann Arbor, 2022
    • PhD
      Case Western Reserve University, Cleveland, 2019
    • BA
      Saint Mary's University of Minnesota, Winona, 2010
    Recent Publications See All Publications
    • Preprint
      Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
      Avelar RA, Gupta R, Carvette G, da Veiga Leprevost F, Colina J, Teitel J, Nesvizhskii AI, O'Connor CM, Hatzoglou M, Shenolikar S, Arvan P, Narla G, DiFeo A. 2024 Mar 28; DOI:10.21203/rs.3.rs-4013396/v1
      PMID: 38585734
    • Journal Article
      Abstract B006: Mutant PPP2R1A induces the expression and secretion of IGFBP2 to promote uterine serous carcinoma metastasis
      Haanen TJ, Boock S, Taylor S, O'Connor C, DiFeo A, Narla G. Clinical Cancer Research, 2024 Mar 1; 30 (5_Supplement): b006 - b006. DOI:10.1158/1557-3265.endo24-b006
    • Journal Article
      Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
      Rasool RU, O'Connor CM, Das CK, Alhusayan M, Verma BK, Islam S, Frohner IE, Deng Q, Mitchell-Velasquez E, Sangodkar J, Ahmed A, Linauer S, Mudrak I, Rainey J, Zawacki KP, Suhan TK, Callahan CG, Rebernick R, Natesan R, Siddiqui J, Sauter G, Thomas D, Wang S, Taylor DJ, Simon R, Cieslik M, Chinnaiyan AM, Busino L, Ogris E, Narla G, Asangani IA. Nat Commun, 2023 Aug 29; 14 (1): 5253 DOI:10.1038/s41467-023-40760-6
      PMID: 37644036
    • Journal Article
      PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
      Jayappa KD, Tran B, Gordon VL, Morris C, Saha S, Farrington CC, O'Connor CM, Zawacki KP, Isaac KM, Kester M, Bender TP, Williams ME, Portell CA, Weber MJ, Narla G. J Clin Invest, 2023 Jul 3; 133 (13): DOI:10.1172/JCI155938
      PMID: 37166997
    • Journal Article
      Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death.
      Avelar RA, Armstrong AJ, Carvette G, Gupta R, Puleo N, Colina JA, Joseph P, Sobeck AM, O'Connor CM, Raines B, Gandhi A, Dziubinski ML, Ma DS, Resnick K, Singh S, Zanotti K, Nagel C, Waggoner S, Thomas DG, Skala SL, Zhang J, Narla G, DiFeo A. Mol Cancer Ther, 2023 May 4; 22 (5): 599 - 615. DOI:10.1158/1535-7163.MCT-21-0880
      PMID: 36788429
    • Journal Article
      Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death
      Avelar R, Armstrong A, Carvette G, Gupta R, Puleo N, Colina J, Joseph P, Sobeck A, O'Connor C, Raines B, Gandhi A, Dziubinski M, Ma D, Resnick K, Singh S, Zanotti K, Nagel C, Waggoner S, Thomas D, Skala S, Zhang J, Narla G, DiFeo A. Molecular Cancer Therapeutics, DOI:10.1158/1535-7163.MCT-21-0880
    • Journal Article
      Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules.
      Haanen TJ, O'Connor CM, Narla G. J Biol Chem, 2022 Dec; 298 (12): 102656 DOI:10.1016/j.jbc.2022.102656
      PMID: 36328247
    • Proceeding / Abstract / Poster
      Abstract 3341: Synthetic lethality by targeting ribonucleotide reductase in PP2A deficient uterine serous carcinoma
      O'Connor CM, Taylor SE, Miller KM, Hurst L, Haanen TJ, Suhan TK, Zawacki KP, Noto FK, Trako J, Mohan A, Sangodkar J, Zamarin D, DiFeo A, Narla G. Cancer Research, 2022 Apr 15; 82 (12_Supplement): 3341 - 3341. DOI:10.1158/1538-7445.am2022-3341