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Available to mentor
Jacqueline Madison, M.D. is a Clinical Assistant Professor in both Rheumatology in the Department of Internal Medicine and Pediatric Rheumatology in the Department of Pediatrics. Dr. Madison earned her bachelor’s degree at Yale University before moving back to her home state of Michigan where she earned her degree in medicine at the University of Michigan. She next completed her Internal Medicine-Pediatrics residency followed by a combined fellowship in adult and pediatric Rheumatology at the University of Michigan.
Dr. Madison sees patients with rheumatic disease across the age spectrum. She cares for children, adolescents, and adults in Rheumatology. She cares for patients with all rheumatic disease and frequently sees patients with arthritis, lupus, antiphospholipid syndrome, myositis, vasculitis, and autoinflammatory disease. She is enthusiastic about helping patients fit their medical needs into a full life.
Dr. Madison participates in research on Antiphospholipid Syndrome (APS) with the Knight Lab. She contributes to research related to understanding the mechanisms of APS and how the disease manifests in a variety of ways in patients. She has a particular interest in pediatric patients with APS. Dr. Madison also has a particular interest in clinical trials in APS and lupus.
Outside of medicine, Dr. Madison enjoys spending time with her family including her partner, children, and dog. She loves traveling, running, enjoying the outdoors, and exploring Ann Arbor’s many parks and playgrounds with her children.
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Doctor of Medicine (M.D.)University of Michigan Medical School, 2013
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Bachelor of Science (B.S.)Yale University, 2009
My research focuses on trying to better understand the pathophysiology, clinical manifestations, and treatment of Antiphospholipid Syndrome (APS), including pediatric APS patients and lupus patients who have antiphospholipid antibodies. In extending research from bench to bedside, I contribute to the translational research of the Knight Lab and to clinical trials. I also study lupus, in addition to and independently of patients with APS. I have particular interest in clinical trials in lupus and the pioneering work of cellular therapy trials in autoimmune disease.
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Tambralli A, Harbaugh A, NaveenKumar SK, Radyk MD, Rysenga CE, Sabb K, Hurley J, Sule G, Yalavarthi S, Estes SK, Hoy CK, Smith T, Sarosh C, Madison JA, Schaefer JK, Sood SL, Zuo Y, Sawalha AH, Lyssiotis CA, Knight JS. Journal of Clinical Investigation, 2024 Jun 3; 134 (11):Journal ArticleNeutrophil glucose flux as a therapeutic target in antiphospholipid syndrome
DOI:10.1172/JCI169893 PMID: 38869951 -
Hoy CK, NaveenKumar SK, Navaz SA, Sugur K, Yalavarthi S, Sarosh C, Smith T, Kmetova K, Chong E, Peters NF, Rysenga CE, Norman GL, Figueroa-Parra G, Nelson D, Girard J, Ahmed AZ, Schaefer JK, Gudjonsson JE, Kahlenberg JM, Madison JA, Knight JS, Crowson CS, Duarte-García A, Zuo Y. Arthritis and Rheumatology, 2024 Jun 1; 76 (6): 928 - 935.Journal ArticleCalprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome
DOI:10.1002/art.42801 PMID: 38225923 -
Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L, Nassi L, Fuller J, Turnier JL, Pascual V, Wright TB, Madison JA, Knight JS, Zia A, Zuo Y. Clinical Immunology, 2024 Apr 1; 261:Journal ArticleNon-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome
DOI:10.1016/j.clim.2024.109926 PMID: 38355030 -
NaveenKumar SK, Tambralli A, Fonseca BM, Yalavarthi S, Liang W, Hoy CK, Sarosh C, Rysenga CE, Ranger CH, Vance CE, Madison JA, Orsi FA, Sood SL, Schaefer JK, Zuo Y, Knight JS. Blood, 2024 Mar 21; 143 (12): 1193 - 1197.Journal ArticleLow ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome
DOI:10.1182/blood.2023022097 PMID: 38237140 -
Kmeťová K, Lonina E, Yalavarthi S, Levine JS, Hoy CK, Sarosh C, Gockman K, Morris AE, Tambralli A, Madison JA, Zuo Y, Subang R, Rauch J, Knight JS. Clinical Immunology, 2023 Oct 1; 255:Journal ArticleInteraction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps
DOI:10.1016/j.clim.2023.109714 PMID: 37527733 -
Weiner JK, Smith T, Hoy CK, Sarosh C, Madison JA, Ambati A, Tambralli A, Peters N, Packel C, Gockman K, Zuo Y, Briceño EM, Nagaraja V, Knight JS. ACR Open Rheumatology, 2023 Jan 1; 5 (1): 28 - 37.Journal ArticlePredictors and Interrelationship of Patient-Reported Outcomes in Antiphospholipid Syndrome: A Cross-Sectional Study
DOI:10.1002/acr2.11512 -
Turnier JL, Yee CM, Madison JA, Rizvi SM, Berthier CC, Wen F, Kahlenberg JM. Arthritis and Rheumatology, 2022 Dec 1; 74 (12): 2024 - 2031.Journal ArticleImaging Mass Cytometry Reveals Predominant Innate Immune Signature and Endothelial–Immune Cell Interaction in Juvenile Myositis Compared to Lupus Skin
DOI:10.1002/art.42283 PMID: 35762881 -
Madison JA, Gockman K, Hoy C, Tambralli A, Zuo Y, Knight JS. Pediatric Rheumatology, 2022 Dec 1; 20 (1):Journal ArticlePediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series
DOI:10.1186/s12969-022-00677-8 PMID: 35197077
