Jacqueline Madison
Clinical Assistant Professor of Internal Medicine
Clinical Assistant Professor of Pediatrics
[email protected]

Available to mentor

Jacqueline Madison
Clinical Assistant Professor
  • About
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Jacqueline Madison, M.D. is a Clinical Assistant Professor in both Rheumatology in the Department of Internal Medicine and Pediatric Rheumatology in the Department of Pediatrics. Dr. Madison earned her bachelor’s degree at Yale University before moving back to her home state of Michigan where she earned her degree in medicine at the University of Michigan. She next completed her Internal Medicine-Pediatrics residency followed by a combined fellowship in adult and pediatric Rheumatology at the University of Michigan.

    Dr. Madison sees patients with rheumatic disease across the age spectrum. She cares for children, adolescents, and adults in Rheumatology. She cares for patients with all rheumatic disease and frequently sees patients with arthritis, lupus, antiphospholipid syndrome, myositis, vasculitis, and autoinflammatory disease. She is enthusiastic about helping patients fit their medical needs into a full life.

    Dr. Madison participates in research on Antiphospholipid Syndrome (APS) with the Knight Lab. She contributes to research related to understanding the mechanisms of APS and how the disease manifests in a variety of ways in patients. She has a particular interest in pediatric patients with APS. Dr. Madison also has a particular interest in clinical trials in APS and lupus.

    Outside of medicine, Dr. Madison enjoys spending time with her family including her partner, children, and dog. She loves traveling, running, enjoying the outdoors, and exploring Ann Arbor’s many parks and playgrounds with her children.

    Qualifications
    • Doctor of Medicine (M.D.)
      University of Michigan Medical School, Ann Arbor, 2013
    • Bachelor of Science (B.S.)
      Yale University, New Haven, 2009
    Research Overview

    My research focuses on trying to better understand the pathophysiology, clinical manifestations, and treatment of Antiphospholipid Syndrome (APS), including pediatric APS patients and lupus patients who have antiphospholipid antibodies. In extending research from bench to bedside, I contribute to the translational research of the Knight Lab and to clinical trials. I also study lupus, in addition to and independently of patients with APS. I have particular interest in clinical trials in lupus and the pioneering work of cellular therapy trials in autoimmune disease.

    Recent Publications See All Publications
    • Journal Article
      Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome.
      Tambralli A, Harbaugh A, NaveenKumar SK, Radyk MD, Rysenga CE, Sabb K, Hurley JM, Sule GJ, Yalavarthi S, Estes SK, Hoy CK, Smith T, Sarosh C, Madison JA, Schaefer JK, Sood SL, Zuo Y, Sawalha AH, Lyssiotis CA, Knight JS. J Clin Invest, 2024 Jun 13; 134 (15): DOI:10.1172/JCI169893
      PMID: 38869951
    • Journal Article
      Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.
      Sloan EE, Kmetova K, NaveenKumar SK, Kluge L, Chong E, Hoy CK, Yalavarthi S, Sarosh C, Baisch J, Walters L, Nassi L, Fuller J, Turnier JL, Pascual V, Wright TB, Madison JA, Knight JS, Zia A, Zuo Y. Clin Immunol, 2024 Apr; 261: 109926 DOI:10.1016/j.clim.2024.109926
      PMID: 38355030
    • Journal Article
      Low ectonucleotidase activity and increased neutrophil-platelet aggregates in patients with antiphospholipid syndrome.
      NaveenKumar SK, Tambralli A, Fonseca BM, Yalavarthi S, Liang W, Hoy CK, Sarosh C, Rysenga CE, Ranger CH, Vance CE, Madison JA, Orsi FA, Sood SL, Schaefer JK, Zuo Y, Knight JS. Blood, 2024 Mar 21; 143 (12): 1193 - 1197. DOI:10.1182/blood.2023022097
      PMID: 38237140
    • Journal Article
      Calprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome.
      Hoy CK, NaveenKumar SK, Navaz SA, Sugur K, Yalavarthi S, Sarosh C, Smith T, Kmetova K, Chong E, Peters NF, Rysenga CE, Norman GL, Figueroa-Parra G, Nelson D, Girard J, Ahmed AZ, Schaefer JK, Gudjonsson JE, Kahlenberg JM, Madison JA, Knight JS, Crowson CS, Duarte-García A, Zuo Y. Arthritis Rheumatol, 2024 Jun; 76 (6): 928 - 935. DOI:10.1002/art.42801
      PMID: 38225923
    • Journal Article
      Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps.
      Kmeťová K, Lonina E, Yalavarthi S, Levine JS, Hoy CK, Sarosh C, Gockman K, Morris AE, Tambralli A, Madison JA, Zuo Y, Subang R, Rauch J, Knight JS. Clin Immunol, 2023 Oct; 255: 109714 DOI:10.1016/j.clim.2023.109714
      PMID: 37527733
    • Journal Article
      Predictors and Interrelationship of Patient-Reported Outcomes in Antiphospholipid Syndrome: A Cross-Sectional Study.
      Weiner JK, Smith T, Hoy CK, Sarosh C, Madison JA, Ambati A, Tambralli A, Peters N, Packel C, Gockman K, Zuo Y, Briceño EM, Nagaraja V, Knight JS. ACR Open Rheumatol, 2023 Jan; 5 (1): 28 - 37. DOI:10.1002/acr2.11512
      PMID: 36461647
    • Journal Article
      Imaging Mass Cytometry Reveals Predominant Innate Immune Signature and Endothelial-Immune Cell Interaction in Juvenile Myositis Compared to Lupus Skin.
      Turnier JL, Yee CM, Madison JA, Rizvi SM, Berthier CC, Wen F, Kahlenberg JM. Arthritis Rheumatol, 2022 Dec; 74 (12): 2024 - 2031. DOI:10.1002/art.42283
      PMID: 35762881
    • Journal Article
      Pediatric antiphospholipid syndrome: clinical features and therapeutic interventions in a single center retrospective case series.
      Madison JA, Gockman K, Hoy C, Tambralli A, Zuo Y, Knight JS. Pediatr Rheumatol Online J, 2022 Feb 23; 20 (1): 17 DOI:10.1186/s12969-022-00677-8
      PMID: 35197077
    Featured News & Stories APS 101: Obstetric APS
    Department News
    APS 101 Series: Obstetric Antiphospholipid Syndrome
    The APS 101 Series, written by Jacqueline Madison, MD, takes you through the ins and outs of APS, providing facts and key information to help you better understand the disorder. In this month’s edition, Dr. Madison discusses obstetric antiphospholipid syndrome, issues that can arise, and treatment strategies.
    APS Research Lab Members Receive Education Awards
    Department News
    APS Research Lab Members Receive Education Awards
    Congratulations to Dr. Yu (Ray) Zuo and Dr. Jacqueline Madison, recipients of annual Department of Internal Medicine and Department of Pediatrics education awards.
    2024 CARRA-AF Grant Awardee, Dr. Jacqueline Madison
    Research News
    2024 CARRA-Arthritis Foundation Research Grant Awardee, Dr. Jacqueline Madison
    Jacqueline Madison, MD, Assistant Professor in the Division of Rheumatology and member of the APS Research Labs, has been awarded the CARRA-Arthritis Foundation Research Grant.