Olesya Plazyo, PhD
Research Investigator
Dermatology
[email protected]

Available to mentor
Olesya Plazyo, PhD
Research Investigator
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
    • About

    Olesya Plazyo, PhD, joined the U-M Department of Dermatology faculty as a Research Investigator in the fall of 2021. She is a member of the Autoimmunity/Immunogenetics in Skin Research Program in the laboratory of Dr. Johann Gudjonsson. Dr. Plazyo is pursuing research focused on deciphering the molecular mechanisms of autoimmune and autoinflammatory diseases affecting skin and beyond, with a special focus on sexual dimorphism in immune response.

    Dr. Plazyo received her PhD in Physiology, with a concentration in reproductive immunology, from the NICHD Perinatology Research Branch and Wayne State University School of Medicine. She completed post doctoral training in cellular cardiology and immunology at Wayne State University, before joining the U-M Department of Dermatology in 2019 as a postdoctoral research fellow.

    Qualifications
    • Post-doctoral Research Fellow
      University of Michigan Medical School, Dermatology, 2021
    • Post-doctoral Research Fellow
      Wayne State University, school of Medicine, 2019
    • Research Investigator
      University of Michigan Medical School, Dermatology
    • Ph.D.
      Wayne State University, Detroit, 2016
    • M.S.
      Wayne State University, Detroit, 2012
    • B.A.
      Wayne State University, Detroit, 2006
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Recent Publications See All Publications
    • Journal Article
      Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
      Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210 DOI:10.1038/s41467-023-44645-6
      PMID: 38172207
    • Presentation
      “Targeting p300 for the Treatment of Scleroderma.”
      Plazyo O. 2024 Oct 17;
    • Presentation
      "Exploring the link between female-biased autoimmunity and preeclampsia"
      Plazyo O. 2024 Oct 7;
    • Journal Article
      Profiling lncRNA in psoriatic skin using scRNA-seq.
      Bogle R, Patrick MT, Sreeskandarajan S, Gharaee-Kermani M, Zhang H, Li Q, Zhou R, Ma F, Kahlenberg JM, Plazyo O, Elder JT, Billi AC, Gudjonsson JE, Tsoi LC. J Invest Dermatol, 2024 Sep 27; DOI:10.1016/j.jid.2024.09.010
      PMID: 39342985
    • Journal Article
      Profiling lncRNA in psoriatic skin using scRNA-seq.
      Bogle R, Patrick MT, Sreeskandarajan S, Gharaee-Kermani M, Zhang H, Li Q, Zhou R, Ma F, Kahlenberg JM, Plazyo O, Elder JT, Billi AC, Gudjonsson JE, Tsoi LC. J Invest Dermatol, 2024 Sep 27; DOI:10.1016/j.jid.2024.09.010
      PMID: 39342985
    • Presentation
      "VGLL3 in autoimmunity" Lupus Research Conference presentation
      Plazyo O. 2024 May 1;
    • Journal Article
      Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling.
      Jiang Y, Gruszka D, Zeng C, Swindell WR, Gaskill C, Sorensen C, Brown W, Gangwar RS, Tsoi LC, Webster J, Sigurðardóttir SL, Sarkar MK, Uppala R, Kidder A, Xing X, Plazyo O, Xing E, Billi AC, Maverakis E, Kahlenberg JM, Gudjonsson JE, Ward NL. JCI Insight, 2024 Mar 12; 9 (8): DOI:10.1172/jci.insight.172764
      PMID: 38470486
    • Journal Article
      HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
      Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE. iScience, 2024 Feb 16; 27 (2): 108986 DOI:10.1016/j.isci.2024.108986
      PMID: 38327798