Jason Miller, MD, PhD

 Jason Miller
James Grosfeld Professor of Ophthalmology and Visual Sciences
Assistant Professor of Ophthalmology and Visual Science
Residency Program Research Director, Medical School
Office:
University of Michigan, Kellogg Eye Center
Ophthalmology and Visual Sciences
1000 Wall Street
Ann Arbor, MI 48105
Email:
[email protected]
Available to mentor
Jason Miller, MD, PhD
Jason Miller
Assistant Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Physician-scientist with a clinical practice dedicated to medical retina and uveitis. Clinical research focus, including clinical trials, involves age-related macular degeneration (AMD). Bench science lab dedicated to primary and iPSC culture models of AMD.

    Links
    • Miller Lab
    • twitter

    Qualifications
    • Clinical Fellow, Medical Retina and Uveitis
      University of Michigan, Ophthalmology, Ann Arbor, United States
      2019 - 2021
      Clinical Fellowship
    • Resident
      University of Michigan, Ophthalmology, Ann Arbor, United States
      2016 - 2019
      Residency
    • Postdoctoral Research Fellow
      University of Michigan, Ophthalmology, Ann Arbor, United States
      2013 - 2016
      Postdoctoral Fellowship
    • Intern, Internal Medicine
      Kaiser Oakland, Internal Medicine, Oakland, United State
      2012 - 2013
      Internship
    • MD, PhD
      University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143, United States
      2002 - 2012
    • BS
      Stanford University, Stanford, California, United States
      1997 - 2002

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design

    Research Overview

    We focus on dry age-related macular degeneration (AMD), and in particular study the lipid biology and metabolism of the primary cell type that dies in this disease, the retinal pigment epithelium (RPE).

    Recent Publications

     See All Publications
    • Preprint
      Peroxisome dysfunction alters metabolism of photoreceptor outer segments in human retinal pigment epithelium.
      Mouzaaber C, Feldman CB, Huguenin SM, Han JYS, Trombly E, Zhang Q, Rieger A, Hojjat H, Huynh BC, Misaghi E, Radziwon A, Fufa TD, Hufnagel RB, Miller JML, Benson MD. 2026 Mar 8; DOI:10.64898/2026.02.01.701576
      PMID: 41676681
    • Journal Article
      Acute and Substantial Vision Loss After Pembrolizumab Immunotherapy for Bladder Cancer
      Pan WW, Waters I, Yousif J, Reichert ZR, Johnson MW, Miller J, Jayasundera KT. JAMA Ophthalmology, 2026 Feb 19; 144 (2): 204 - 206. DOI:10.1001/jamaophthalmol.2025.5068
      PMID: 41379437
    • Journal Article
      Central bouquet hemorrhage with Henle fiber layer extension in myopic eyes
      Fogel Levin M, Querques G, Sacconi R, Miller JML, Johnson MW, Miere A, Souied E, Kunkler A, Yannuzzi NA, Fung AT, Freund KB, Bacci T, Ramtohul P, Yannuzzi L, Sadda SVR, Baumal CR, Christakis P, Gupta RR, Ip M, Santina A, Au A, Sarraf D. Canadian Journal of Ophthalmology, 2025 Oct 1; 60 (5): 289 - 296. DOI:10.1016/j.jcjo.2025.03.019
      PMID: 40288421
    • Journal Article
      Dissecting the biological complexity of age-related macular degeneration: Is it one disease, multiple separate diseases, or a spectrum?
      Miller JML, Thompson BR, Handa JT, Luthert P, Chakravarthy U, Csaky KG, Bird A, Young BK, Iyengar SK, Baek J, Zouache MA, Richards BT, Hageman GS, Rodrigues G, Bharti K, Flannery JG, Gorin MB, Bowes Rickman C. Experimental Eye Research, 2025 May 1; 254: DOI:10.1016/j.exer.2025.110304
      PMID: 39983974
    • Journal Article
      Basic science observations link subretinal drusenoid deposit formation to retinal pigment epithelial hypoxia
      Digsby K, Zhang Q, Miller JML. Eye Basingstoke, 2025 Mar 1; 39 (4): 790 - 792. DOI:10.1038/s41433-024-03167-1
      PMID: 38871936
    • Journal Article
      IGFBP5 as a Novel Basolateral Secretion Marker in the Retinal Pigment Epithelium
      Digsby KM, Zhang Q, Perera ND, Karoukis A, DenDekker A, Fahim AT, Miller JML. Advances in Experimental Medicine and Biology, 2025 Jan 1; 1468: 357 - 362. DOI:10.1007/978-3-031-76550-6_59
      PMID: 39930222
    • Journal Article
      Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos
      Rozumek GM, Brinkmeier ML, Guan B, Wang SQ, Tower C, Yang NT, Lim RS, Kong D, Soden D, Zhang Q, Han JYS, Miller JML, Dong L, Hannum DF, Moroi SE, Richards JE, Hufnagel RB, Prasov L. Jci Insight, 2025 Jan 1; 11 (6): 1 - 21. DOI:10.1172/jci.insight.194681
      PMID: 41746734
    • Journal Article
      Tocilizumab for Silicone Oil-Induced Recalcitrant Cystoid Macular Edema in a Patient with Recurrent Acute Retinal Necrosis-Associated Retinal Detachment
      Pan WW, Mansoor M, Riccardi D, Madison JA, Wubben TJ, Kodati S, Miller J. Ocular Immunology and Inflammation, 2025 Jan 1; 33 (8): 1869 - 1872. DOI:10.1080/09273948.2025.2519849
      PMID: 40531822

    Featured News & Stories

         eye drawing yellow dots
    Department News

    UM researchers awarded grants from BrightFocus Foundation for vision research

    BrightFocus Foundation awarded $15.2M in research grants for Alzheimer’s, macular degeneration, and glaucoma, including support for Michigan Medicine researchers Jason Miller, MD, PhD, and Mark Draelos, MD, PhD, advancing new approaches to vision loss and disease detection.
         Three white men are standing in front of a window. They are facing forward and smiling.
    Medicine at Michigan

    $11.5 million fuels innovation in sight-saving research

    James Grosfeld has given $11.5 million to Michigan Medicine for research related to dry age-related macular degeneration (AMD).