Melissa Elafros, MD, PhD
Andrea and Lawrence A Wolfe Research Professor
Assistant Professor of Neurology
Department of Neurology
109 Zina Pitcher PL, 5015 AAT-BSRB
Ann Arbor, MI 48109

Available to mentor

Melissa Elafros, MD, PhD
Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Elafros is the Andrea and Lawrence A. Wolfe Research Professor in the Department of Neurology. With a focus on improving access to quality neurologic care for resource-limited populations in the U.S. and in low-middle-income countries, she conducts epidemiologic, health services, and clinical research aimed at determining risk factors for neurologic morbidity and mortality in these settings.

    In 2009, Dr Elafros began conducting research in Zambia focused on the medical and psychosocial burden of neurologic disease. Since then, she has been continuously involved in research with patients, caregivers, and healthcare workers regarding the most pressing neurologic concerns in sub-Saharan Africa. Her first NIH-funded study examined barriers to care for meningitis, a condition that continues to cause significant mortality and morbidity worldwide. In August 2023, she launched the Zambian Cohort of Healthy Aging and Dementia (Z-CHAD) study in collaboration with Zambian neurologists and neuropsychologists. This study is determining the prevalence of dementia and associated risk factors in Zambia while also characterizing the burden and barriers to care faced by these patients and their caregivers.

    Dr. Elafros also has an active research and clinical practice in Michigan. The Flint Neuropathy Study is an ongoing collaboration with Hurley Medical Center and McLaren Flint examining the prevalence of neuropathy and dementia in a predominantly Black, low-income primary care population. This work is formally characterizing barriers to neuropathy and dementia diagnosis and management in this population, which will then serve as the basis for interventions improving the management of brain and nerve health in this setting.

    Dr. Elafros' research has been funded by the National Institutes of Health, American Medical Association, American Academy of Neurology, and American Neurological Association. She has authored several peer-reviewed publications and is in demand as a speaker at leading institutions around the world. She is dedicated to capacity building and has mentees in three countries.

    Qualifications
    • Fellowship
      University of Michigan, Neuromuscular, 2021
    • Residency
      Johns Hopkins Hospital, Adult Neurology, 2020
    • Internship
      Johns Hopkins Hospital, Department of Medicine, 2017
    • M.D.
      Michigan State University, East Lansing, MI, 2016
    • Ph.D., Epidemiology
      Michigan State University, East Lansing, MI, 2014
    • B.A., Spanish
      Michigan State University, East Lansing, MI, 2008
    • B.S., Human Biology
      Michigan State University, East Lansing, MI, 2008
    • M.A., Bioethics
      Michigan State University, East Lansing, MI, 2008
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Institute for Healthcare Policy and Innovation
    • Center Member
      Global REACH
    Research Overview

    - Identification of risk factors for neurologic diseases in resource-limited regions of the United States and in low-middle income countries.
    - Characterization of the psychosocial burden of neurologic diseases, including stigma, among affected individuals and their social networks.
    - Identifying and addressing barriers to improve access to quality neurologic care and services for resource-limited populations.

    Recent Publications See All Publications
    • Journal Article
      Prevalence and Risk Factors of Distal Symmetric Polyneuropathy Among Predominantly Non-Hispanic Black, Low-Income Patients.
      Elafros MA, Brown A, Marcus H, Dawood T, Bachuwa GI, Banerjee M, Winch PJ, Kvalsund M, Feldman EL, Skolarus LE, Callaghan BC. Neurology, 2024 Jun; 102 (11): e209390 DOI:10.1212/WNL.0000000000209390
      PMID: 38718313
    • Journal Article
      Patient and health care provider knowledge of diabetes and diabetic microvascular complications: a comprehensive literature review.
      Elafros MA, Callaghan BC, Skolarus LE, Vileikyte L, Lawrenson JG, Feldman EL. Rev Endocr Metab Disord, 2023 Apr; 24 (2): 221 - 239. DOI:10.1007/s11154-022-09754-5
      PMID: 36322296
    • Journal Article
      Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new treatments.
      Elafros MA, Andersen H, Bennett DL, Savelieff MG, Viswanathan V, Callaghan BC, Feldman EL. Lancet Neurol, 2022 Oct; 21 (10): 922 - 936. DOI:10.1016/S1474-4422(22)00188-0
      PMID: 36115364
    • Journal Article
      The Global Burden of Polyneuropathy-In Need of an Accurate Assessment.
      Elafros MA, Kvalsund MP, Callaghan BC. JAMA neurology, 2022 Jun 1; 79 ((6)): 537 - 538.
    • Journal Article
      A qualitative study of patient, caregiver, doctor and nurse views of factors influencing lumbar puncture uptake in Zambia.
      Elafros MA, Belessiotis-Richards C, Birbeck GL, Bond V, Sikazwe I, Kvalsund MP. Trans R Soc Trop Med Hyg, 2022 Apr 4; 116 (4): 322 - 327. DOI:10.1093/trstmh/trab124
      PMID: 34352890
    • Journal Article
      A qualitative study of factors resulting in care delays for adults with meningitis in Zambia.
      Elafros MA, Bwalya C, Muchanga G, Mwale M, Namukanga N, Birbeck GL, Chomba M, Mugala-Mulenga A, Kvalsund MP, Sikazwe I, Saylor DR, Winch PJ. Trans R Soc Trop Med Hyg, 2022 Dec 2; 116 (12): 1138 - 1144. DOI:10.1093/trstmh/trac049
      PMID: 35653707
    • Journal Article
      The Global Burden of Polyneuropathy-In Need of an Accurate Assessment.
      Elafros MA, Kvalsund MP, Callaghan BC. JAMA Neurol, 2022 Jun 1; 79 (6): 537 - 538. DOI:10.1001/jamaneurol.2022.0565
      PMID: 35404377
    • Journal Article
      Lumbar Puncture-Related Knowledge, Attitudes, and Practices among Patients, Caregivers, Doctors, and Nurses in Zambia.
      Elafros MA, Belessiotis-Richards C, Birbeck GL, Bond V, Sikazwe I, Kvalsund MP. Am J Trop Med Hyg, 2021 Mar 22; 104 (5): 1925 - 1931. DOI:10.4269/ajtmh.20-0509
      PMID: 33755588
    Featured News & Stories assessing intraepidermal nerve fiber density from a skin biopsy showing nerve fibers
    Research News
    Peripheral Neuropathy Diagnostic Tools
    Researchers compared two diagnostic tools used in neuropathy, one much less invasive, to understand which was more effective.
    Dr. Melissa Elafros with Andi and Larry Wolfe before she is installed as the inaugural Wolfe Research Professor
    Research News
    The Andrea and Lawrence A. Wolfe Research Professorship
    In June, the NeuroNetwork for Emerging Therapies celebrated the generosity of two remarkable donors, Andi and Larry Wolfe, and the installation of Melissa Elafros, M.D., Ph.D., as the inaugural Andrea and Lawrence A. Wolfe Research Professor at a ceremony and reception on the Michigan Medicine campus.
    obese person walking with a shadow stretched out behind them
    Research News
    Obesity-related Neuropathy: The New Epidemic
    Researchers reviewed the latest research on obesity-related neuropathy and possible treatment options.
    WDIV Click On Detroit segment on Neuropathy
    Research News
    Neuropathy Research Covered Nationwide
    Television stations nationwide covered neuropathy research by Andrea and Lawrence A. Wolfe Research Professor of Neurology Melissa Elafros, M.D., Ph.D., based in Flint, MI.
    The Z-CHAD data collection team launching data collection in Chipata compound with Dr. Mataa(center)
    Research News
    The Impact of Alzheimer's in Zambia
    The Zambia Cohort of Healthy Aging and Dementia Study (Z-CHAD) was launched by Andrea and Lawrence A. Wolfe Research Professor Melissa Elafros, M.D., Ph.D., to understand the true impact of dementia on patients in Zambia and their caregivers.
    photo of Melissa Elafros
    Research News
    Dr. Melissa Elafros Featured CAPRA Awardee
    The Center to Accelerate Population Research in Alzheimer's (CAPRA) featured Andrea and Lawrence A. Wolfe Research Professor Melissa Elafros, M.D., Ph.D., in the CAPRA Quarterly Winter 2024 edition.