3062 Biomedical Sciences Research Bldg.
Ann Arbor, MI 48109
Available to mentor
Dr. Pierre A. Coulombe, a native of Montréal, Québec, Canada, serves as the G. Carl Huber Professor and Chair of the Department of Cell & Developmental Biology at the University of Michigan Medical School. He is jointly appointed in the Department of Dermatology and is a member of the Rogel Cancer Center, and the Center for Plasticity and Organ Design, at the same institution. Dr. Coulombe joined U-M in 2017 following a 25 year-stay on faculty, including 9 years as the EV McCollum Professor and Chair of the Department of Biochemistry and Molecular Biology, at Johns Hopkins University. Dr. Coulombe’s research is focused on cell differentiation, tissue homeostasis and response to stress in surface epithelia. His research is relevant to the pathophysiology of rare skin disorders, psoriasis and related conditions, and non-melanoma skin cancer. Besides research, Dr. Coulombe has a long standing passion for graduate and post-graduate education and training, and with the Pachyonychia Project, a patient and rare disease advocacy group.
Cell & Developmental Biology Lab website twitter
-
Postdoctoral FellowUniversity of Chicago, Molecular Biology & Genetics, 1992
-
PhD, PharmacologyUniversité de Montréal, 1987
-
BScUniversité du Québec à Montréal, 1982
-
Center MemberRogel Cancer Center
-
Center MemberCenter for Cell Plasticity and Organ Design
- Cell differentiation and tissue homeostasis in surface epithelia
- Regulation of inflammation and innate immunity
- Structure, properties, and function of intermediate filaments
- Role of keratin proteins in signaling pathways and in the nucleus
- Role of keratin proteins in tumor inception and growth
-
Coulombe PA. The Journal of experimental medicine, 2025 May 5; 222 (5):Journal ArticleA "second hit" impacts disease severity in a dominantly inherited genetic skin disorder
DOI:10.1084/jem.20242377 PMID: 39976599 -
Coulombe PA, Hansen D, Hickerson R, Hovnanian A, O'Toole EA, Kelsell DP, Evans H, Schwartz J, Sprecher E. Journal of Investigative Dermatology, 2025 Apr 1; 145 (4): 725 - 727.Journal ArticleCelebrating 20 Years of the International Pachyonychia Congenita Consortium
DOI:10.1016/j.jid.2024.07.033 PMID: 39453287 -
Redmond CJ, Steiner SN, Cohen E, Johnson CN, Özlü N, Coulombe PA. 2025 Feb 27;PreprintKeratin 15 promotes a progenitor cell state in basal keratinocytes of skin epidermis.
DOI:10.1101/2025.02.27.640633 PMID: 40060679 -
Cohen E, Xu Y, Orosco A, Wang D, Johnson CN, Steen K, Sarkar MK, Özlü N, Tsoi LC, Gudjonsson JE, Parent CA, Coulombe PA. 2024 Dec 27;PreprintKeratin 16 spatially inhibits type I interferon responses in stressed skin.
DOI:10.1101/2024.12.27.630544 PMID: 39763960 -
SenGupta S, Cohen E, Serrenho J, Ott K, Coulombe PA, Parent CA. 2024 Oct 12;PreprintTGFβ1-TNFα regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transitions in breast tumor cells.
DOI:10.1101/2024.10.11.617845 PMID: 39416223 -
Redmond CJ, Cohen E, Johnson CN, Coulombe P. Journal of Investigative Dermatology, 2024 Jul 20; 144 (8): s67Journal Article388 The balance between K14 and K15 regulates progenitor keratinocyte identity and commitment to differentiation in epidermis
DOI:10.1016/j.jid.2024.06.404 -
Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. Journal of Investigative Dermatology, 2024 Jul 21; 144 (8): s86Journal Article496 The stress-induced K16 and K17 differentially regulate innate immune responses in skin
DOI:10.1016/j.jid.2024.06.512 -
Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. PLoS Biology, 2024 Aug 1; 22 (8):Journal ArticleRepeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCα-dependent manner
DOI:10.1371/journal.pbio.3002779 PMID: 39159283
