3062 Biomedical Sciences Research Bldg.
Ann Arbor, MI 48109
Available to mentor
Dr. Pierre A. Coulombe, a native of Montréal, Québec, Canada, serves as the G. Carl Huber Professor and Chair of the Department of Cell & Developmental Biology at the University of Michigan Medical School. He is jointly appointed in the Department of Dermatology and is a member of the Rogel Cancer Center, and the Center for Plasticity and Organ Design, at the same institution. Dr. Coulombe joined U-M in 2017 following a 25 year-stay on faculty, including 9 years as the EV McCollum Professor and Chair of the Department of Biochemistry and Molecular Biology, at Johns Hopkins University. Dr. Coulombe’s research is focused on cell differentiation, tissue homeostasis and response to stress in surface epithelia. His research is relevant to the pathophysiology of rare skin disorders, psoriasis and related conditions, and non-melanoma skin cancer. Besides research, Dr. Coulombe has a long standing passion for graduate and post-graduate education and training, and with the Pachyonychia Project, a patient and rare disease advocacy group.
Cell & Developmental Biology Lab website twitter
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Postdoctoral FellowUniversity of Chicago, Molecular Biology & Genetics, 1992
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PhD, PharmacologyUniversité de Montréal, Montréal, 1987
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BScUniversité du Québec à Montréal, Montréal, 1982
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Center MemberRogel Cancer Center
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Center MemberCenter for Cell Plasticity and Organ Design
- Cell differentiation and tissue homeostasis in surface epithelia
- Regulation of inflammation and innate immunity
- Structure, properties, and function of intermediate filaments
- Role of keratin proteins in signaling pathways and in the nucleus
- Role of keratin proteins in tumor inception and growth
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Redmond CJ, Cohen E, Johnson CN, Coulombe P. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s67Journal Article388 The balance between K14 and K15 regulates progenitor keratinocyte identity and commitment to differentiation in epidermis
DOI:10.1016/j.jid.2024.06.404 -
Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s86Journal Article496 The stress-induced K16 and K17 differentially regulate innate immune responses in skin
DOI:10.1016/j.jid.2024.06.512 -
Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. PLoS Biol, 2024 Aug; 22 (8): e3002779Journal ArticleRepeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCα-dependent manner.
DOI:10.1371/journal.pbio.3002779 PMID: 39159283 -
Carpenter ES, Kadiyala P, Elhossiny AM, Kemp SB, Li J, Steele NG, Nicolle R, Nwosu ZC, Freeman J, Dai H, Paglia D, Du W, Donahue K, Morales J, Medina-Cabrera PI, Bonilla ME, Harris L, The S, Gunchick V, Peterson N, Brown K, Mattea M, Espinoza CE, McGue J, Kabala SM, Baliira RK, Renollet NM, Mooney AG, Liu J, Bhalla S, Farida JP, Ko C, Machicado JD, Kwon RS, Wamsteker E-J, Schulman A, Anderson MA, Law R, Prabhu A, Coulombe PA, Rao A, Frankel TL, Bednar F, Shi J, Sahai V, Pasca Di Magliano M. Clin Cancer Res, 2024 Jun 3; 30 (11): 2497 - 2513.Journal ArticleKRT17high/CXCL8+ Tumor Cells Display Both Classical and Basal Features and Regulate Myeloid Infiltration in the Pancreatic Cancer Microenvironment.
DOI:10.1158/1078-0432.CCR-23-1421 PMID: 37851080 -
Wang Y, Jerome NA, Kelleher A, Henderson ML, Day M, Coulombe PA, Palmbos PL. Clinical Cancer Research, 2024 May 17; 30 (10_Supplement): a019 - a019.Journal ArticleAbstract A019: TRIM29 enhances the invasion of bladder cancer cells by modulating the intermediate filament network and focal adhesions
DOI:10.1158/1557-3265.bladder24-a019 -
Arya SB, Collie SP, Xu Y, Fernandez M, Sexton JZ, Mosalaganti S, Coulombe PA, Parent CA. 2024 Apr 26;PreprintNeutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.
DOI:10.1101/2024.04.21.590456 PMID: 38712240 -
O'Toole EA, Kelsell DP, Caterina MJ, de Brito M, Hansen D, Hickerson RP, Hovnanian A, Kaspar R, Lane EB, Paller AS, Schwartz J, Shroot B, Teng J, Titeux M, Coulombe PA, Sprecher E. J Invest Dermatol, 2024 Apr; 144 (4): 748 - 754.Journal ArticlePachyonychia Congenita: A Research Agenda Leading to New Therapeutic Approaches.
DOI:10.1016/j.jid.2023.10.030 PMID: 38099888 -
Cohen E, Johnson CN, Wasikowski R, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, Coulombe PA. iScience, 2024 Feb 16; 27 (2): 108805Journal ArticleSignificance of stress keratin expression in normal and diseased epithelia.
DOI:10.1016/j.isci.2024.108805 PMID: 38299111
