David M Fresco
Department of Psychiatry
2559 Rachel Upjohn Building, 4250 Plymouth Road
Ann Arbor, Michigan 48109-2435
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About
David M. Fresco is Professor of Psychiatry and Research Professor at the Institute for Social Research (ISR), Director of the omHealth Lab (ॐ+mHealth), Research Director for Michigan Mindfulness.
Links
Michigan Mindfulness Data Science for Dynamic Intervention Decision Making Center (d3c) omHealth (ॐ+mHealth)
Qualifications
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Postdoctoral FellowTemple University, Psychology, Philadelphia, United States
1999 - 2001
Postdoctoral Fellowship
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PhDUniversity of North Carolina, Chapel Hill, NC, United States
1991 - 1999
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MA, Clinical PsychologyUniversity of North Carolina, Davie Hall, Chapel Hill, NC, 27599, United States
1991 - 1994
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BATemple University, Philadelphia, PA, United States
1986 - 1990
Center Memberships
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Center MemberEisenberg Family Depression Center
Research Overview
His program of research adopts an affective neuroscience perspective to conduct basic, translational, and treatment studies of anxiety and mood disorders, particularly distress disorders (e.g., major depressive disorder, generalized anxiety disorder, and post-traumatic stress disorder) incorporating methodologies including functional neuroimaging (fMRI & EEG), peripheral psychophysiology, and serum markers (e.g., inflammation, neurodegeneration).
Another facet of Dr. Fresco’s research has focused on the development of treatments informed by affective and contemplative neuroscience findings that incorporate mindfulness meditation and other practices derived from Buddhist mental training exercises.
Increasingly, with collaborators at ISR within the Data Science for Dynamic Intervention Decision-Making Center (d3c). Dr. Fresco has initiated clinical trials for treatment optimization and implementation utilizing adaptive intervention methodology (e.g., sequential multiple assignment randomized trials [SMART] & just-in-time adaptive interventions [JITAIs]).
Dr. Fresco has also joined and contributed to the Strong Minds and Enhanced Vision initiative at the Kellogg Eye Center, University of Michigan, led by Dr. Thiran Jayasundera, which aims to characterize and resolve the emotional distress experienced by vision patients as they confront the possibility and eventuality of vision loss.
Much of his current and recent NIH-funded research has focused on examining neurobehavioral mechanisms and efficacy of mindfulness-enriched treatments for chronic illnesses, and the role of emotion regulation strategies in everyday life to reduce distress.
Recent Publications
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Loschiavo MJ, Gebert RR, Jacobs JM, Hoyt MA, Mennin DS, Fresco DM, Dunderdale LE, Applebaum AJ. 2027 Mar 18;Proceeding / Abstract / PosterTreatment credibility and therapeutic alliance in an RCT of two active psychotherapies for cancer caregivers
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Russman Block S, Peltier S, Hovakimian S, Mannella K, Litinas K, Fitzgerald K, Fresco D, Taylor S. 2026 Oct 8;Proceeding / Abstract / PosterMarkers of Success in rt-fMRI-NF Targeting the Prefrontal Cortex and Alternate Region Controls During Emotion Regulation
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Sgherza TR, Becerra R, Bylsma LM, Fresco DM, Naragon-Gainey K. Journal of Affective Disorders, 2026 Jul 15; 405:Journal ArticleInvestigating functional impairment as a mediator of the association between internalising symptoms and low wellbeing
DOI:10.1016/j.jad.2026.121517 PMID: 41763322 -
Szkutak A, Lee HH, Quintero JM, Aldao A, Fresco DM, Mennin DS. Behavior Therapy, 2026 Jul 1; 57 (4): 640 - 653.Journal ArticleChanges in Phasic Heart Rate Variability Predict Clinical Outcomes Following Emotion Regulation Therapy for Generalized Anxiety Disorder and Comorbid Depression
DOI:10.1016/j.beth.2026.02.001 PMID: 42276683 -
Afaneh H, Kalmbach D, Cheng P, Reffi A, Jennings M, Hirata M, Pitts D, Ong J, Fresco D, Swanson L, O'Brien L, Drake C. Sleep, 2026 May 10; 49 (Supplement_1): a212 - a212.Proceeding / Abstract / Poster0476 Mindfulness Enhances Antidepressant Outcomes for Pregnant Women with Insomnia and Depression: A Comparative Effectiveness Randomized Controlled Trial
DOI:10.1093/sleep/zsag091.0475 -
Hovakimian S, Litinas K, Mannella K, Fresco D, Peltier SJ, Taylor S, Russman Block S. 2026 Apr 1;Proceeding / Abstract / PosterLinguistic Expression and Cognitive Reappraisal Success: Pilot Findings from Real-Time fMRI Neurofeedback Training
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Russman Block S, Hovakimian S, Mannella K, Litinas K, Fitzgerald K, Fresco D, Peltier SJ, Taylor S. 2026 Apr 1;Proceeding / Abstract / PosterThe Effects of Real-Time fMRI Neurofeedback on Emotion Regulation in Adult with and Without Anxiety: A pilot study
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Kalmbach D, Afaneh H, Cheng P, Reffi A, Jennings M, Hirata M, Pitts D, Ong JC, Fresco DM, Swanson L, O'Brien L, Drake C. Sleep Medicine, 2026 Jan 31; 138: 107360Journal ArticleMindfulness-imbued insomnia therapy enhances antidepressant outcomes for pregnant women with insomnia and depression: A comparative effectiveness randomized controlled trial of CBTI and PUMAS
DOI:10.1016/j.sleep.2025.107360