Assistant Professor of Internal Medicine
Internal Medicine, Division of Metabolism, Endocrinology & Diabetes
1000 Wall Street, 5132 Brehm Tower
Ann Arbor, MI 48105
[email protected]
1000 Wall Street, 5132 Brehm Tower
Ann Arbor, MI 48105
Available to mentor
Rachel Leigh Byerley Reinert
Assistant Professor
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FellowshipUniversity of Michigan, Internal Medicine; Division of Metabolism, Endocrinology & Diabetes, 2019
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ResidencyUniversity of Michigan, Internal Medicine, 2019
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MDVanderbilt University School of Medicine, 2201 West End, 2014
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PhDVanderbilt University, Medical Scientist Training Program, 2201 West End, 2012
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BSUniversity of Southern Indiana, Evansville, 2005
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Center MemberCaswell Diabetes Institute
Pancreatic islet cells are responsible for synthesizing, packaging, and secreting glucose-regulating hormones, including insulin and glucagon. Disruption of these processes contributes to hyperglycemia in diabetes mellitus. My laboratory group studies how cellular protein quality control mechanisms regulate hormone processing and define islet cell function.
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Reinert RB, Cai Q, Hong J-Y, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CVE, Brissova M, Powers AC. Development, 2014 Apr; 141 (7): 1480 - 1491.Journal ArticleVascular endothelial growth factor coordinates islet innervation via vascular scaffolding.
DOI:10.1242/dev.098657 PMID: 24574008 -
Reinert RB, Kantz J, Misfeldt AA, Poffenberger G, Gannon M, Brissova M, Powers AC. PLoS One, 2012 7 (3): e33529Journal ArticleTamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice.
DOI:10.1371/journal.pone.0033529 PMID: 22470452 -
Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ. Diabetes, 2010 Dec; 59 (12): 3090 - 3098.Journal ArticleConditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
DOI:10.2337/db10-0624 PMID: 20802254 -
ZHU W, PAN L, CHIARA RUSSO A, RAY R, PEDERSON B, SHRESTHA N, QI L, REINERT RB. Diabetes, 2024 Jun 14; 73 (Supplement_1):Journal Article289-OR: Autophagy Promotes Islet α-Cell Function by Maintaining ER Proteostasis and Glucagon Production
DOI:10.2337/db24-289-or -
Iyengar JJ, Ang L, Rodeman KB, Rao A, Lin YK, Broome DT, Fanous N, Reinert RB, Konigsberg A, Weatherup E, Hagar C, Rogosch D, Florek J, Carey B, Wyckoff J, Lee J, Thomas IH, Soleimanpour SA. Endocr Pract, 2024 Feb; 30 (2): 113 - 121.Journal ArticleA Novel Receivership Model for Transition of Young Adults With Diabetes: Experience From a Single-center Academic Transition Program.
DOI:10.1016/j.eprac.2023.11.008 PMID: 38029926 -
Abdon B, Liang Y, da Luz Scheffer D, Torres M, Shrestha N, Reinert RB, Lu Y, Pederson B, Bugarin-Lapuz A, Kersten S, Qi L. JCI Insight, 2023 Aug 3; 8 (17):Journal ArticleMuscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.
DOI:10.1172/jci.insight.170387 PMID: 37535424 -
REINERT RB, ZHU W, PAN L, CHIARA RUSSO A, RAY R, SHRESTHA N, LINDBERG I, Qi LING. Diabetes, 2023 Jun 25; 72 (Supplement_1):Proceeding / Abstract / Poster1768-P: Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Regulates PC2 Function and Proglucagon Processing in Islet α-Cells
DOI:10.2337/db23-1768-p -
Richardson TM, Saunders DC, Haliyur R, Shrestha S, Cartailler J-P, Reinert RB, Petronglo J, Bottino R, Aramandla R, Bradley AM, Jenkins R, Phillips S, Kang H, Human Pancreas Analysis Program , Caicedo A, Powers AC, Brissova M. Am J Physiol Endocrinol Metab, 2023 Mar 1; 324 (3): E251 - E267.Journal ArticleHuman pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.
DOI:10.1152/ajpendo.00246.2022 PMID: 36696598
