Stephanie Moon, PhD
Assistant Professor of Human Genetics, Medical School
Office:
MM Medical School
Human Genetics
1241 Catherine St, 4909 Buhl
Ann Arbor, MI 48109-5618
Human Genetics
1241 Catherine St, 4909 Buhl
Ann Arbor, MI 48109-5618
Email:
[email protected]
Phone:
Available to mentor
Stephanie Moon, PhD
Assistant Professor
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About
Our group is interested in how genes are expressed via the coordinated regulation of messenger RNAs at the levels of translation, localization, and decay. We study mRNA regulation in the context of human disease and stress, with a particular interest in neurological disorders including amyotrophic lateral sclerosis, dementias, and dystonia. Our research aims to reveal the underlying principles and mechanisms governing mRNA in both health and disease to elucidate new therapeutic and diagnostic strategies.
Links
The Moon Lab
Qualifications
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Post-doctoral fellowHoward Hughes Medical Institute & University of Colorado-Boulder, Biochemistry, USA
2014 - 2019
Postdoctoral Fellowship
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Ph.D., PathologyColorado State University, Fort Collins, United States
2009 - 2014
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B.S., ChemistryFort Lewis College, United States
2003 - 2008
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B.S., BiologyFort Lewis College, USA
2003 - 2008
Center Memberships
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberRogel Cancer Center
Research Overview
- Translational control and RNA condensation during the integrated stress response
- Regulation of nucleocytoplasmic compartmentalization of mRNA and RNA binding proteins
- Mechanisms of disease-associated mutations in integrated stress response pathway genes
- Mechanisms of VCP/p97 remodeling and dysregulation in multisystem proteinopathy
Recent Publications
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Khamari L, Tang J, Moon SL, Walter NG. Nature Communications, 2026 Oct 30;Journal ArticleNpl4 decodes polyubiquitin length and undergoes D1-gated exchange on p97/VCP
DOI:10.1038/s41467-026-78860-8 -
Helton NS, Dodd B, Moon SL. Genes Dev, 2026 Oct 1; 40 (19-20): 1724 - 1746.Journal ArticleTemporal gating dictates stress-induced transcript export from the nucleus.
DOI:10.1101/gad.353896.126 PMID: PMC13637645 -
Kim R, Calle Urgiles E, Moon SL. RNA Biology, 2026 Sep 8;Journal ArticleStress granules at the crossroads of the proteostasis network
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Khamari L, Tang J, Moon S, Walter NG. Nature Communications, 2026 Sep 8;Journal ArticleNp14 decodes polyubiquitin length and gates D1-D2 coupling in human VCP/p97
DOI:10.64898/2026.01.722286 -
Tang J, Dodd B, Gao G, Khamari L, Dai L, Schmidt A, Moon SL, Walter NG. Biophysical Journal, 2025 Feb 15; 124 (3): 371aProceeding / Abstract / PosterBPS2025 - Neurodegenerative ATPase VCP mutant and wild-type co-assembly, stoichiometry, and functional assessment by single molecule assays
DOI:10.1016/j.bpj.2024.11.2010 -
Tang J, Dodd B, Schmidt A, Moon SL, Walter NG. Biophysical Journal, 2024 Feb 10; 123 (3): 476aProceeding / Abstract / PosterNeurodegenerative VCP mutant and wild-type co-assembly and stoichiometry assessment by single-molecule assays
DOI:10.1016/j.bpj.2023.11.2890 -
Moon S. 2022 Oct 26;PresentationRegulation of RNA in stress and disease
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Moon S. The FASEB Journal, 2022 May 5; 36 (S1):Proceeding / Abstract / PosterRegulation of Stress Granule Dynamicity by Valosin‐Containing Protein
DOI:10.1096/fasebj.2022.36.s1.0i205
Featured News & Stories
Department News
Highlighted Publications: January - May 2026
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Health Lab
Researchers determine how cells prevent RNA traffic jams under stress
New research discovers how cells prevent RNA traffic jams under stress, which could help fight disease
Department News
Highlighted Publications - June 2025
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Highlighted Publications - August 2024
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Highlighted Publications - May 2024
Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
Department News
Research Scouts grants awarded to Stephanie Moon, Lev Prasov, and Tom Wilson
An agile, low-burden program which gives money to Research Scouts to invest in other scientists' bold ideas.
