Stephanie Moon, PhD

 portrait of Stephanie L Moon
Assistant Professor of Human Genetics
Medical School
Office:
MM Medical School
Human Genetics
1241 Catherine St, 4909 Buhl
Ann Arbor, MI 48109-5618
Email:
[email protected]
Phone:
Available to mentor
Stephanie Moon, PhD
portrait of Stephanie L Moon
Assistant Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Our group is interested in how genes are expressed via the coordinated regulation of messenger RNAs at the levels of translation, localization, and decay. We study mRNA regulation in the context of human disease and stress, with a particular interest in neurological disorders including amyotrophic lateral sclerosis, dementias, and dystonia. Our research aims to reveal the underlying principles and mechanisms governing mRNA in both health and disease to elucidate new therapeutic and diagnostic strategies.

    Links
    • The Moon Lab

    Qualifications
    • Post-doctoral fellow
      Howard Hughes Medical Institute & University of Colorado-Boulder, Biochemistry, USA
      2014 - 2019
      Postdoctoral Fellowship
    • Ph.D., Pathology
      Colorado State University, Fort Collins, United States
      2009 - 2014
    • B.S., Chemistry
      Fort Lewis College, United States
      2003 - 2008
    • B.S., Biology
      Fort Lewis College, USA
      2003 - 2008

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design

    Research Overview

    - Translational control and RNA condensation during the integrated stress response
    - Regulation of nucleocytoplasmic compartmentalization of mRNA and RNA binding proteins
    - Mechanisms of disease-associated mutations in integrated stress response pathway genes
    - Mechanisms of VCP/p97 remodeling and dysregulation in multisystem proteinopathy

    Recent Publications

     See All Publications
    • Journal Article
      Temporal gating dictates stress-induced transcript export from the nucleus.
      Helton NS, Dodd B, Moon SL. Genes Dev, 2026 Aug 11; DOI:10.1101/gad.353896.126
      PMID: 42580852
    • Proceeding / Abstract / Poster
      BPS2025 - Neurodegenerative ATPase VCP mutant and wild-type co-assembly, stoichiometry, and functional assessment by single molecule assays
      Tang J, Dodd B, Gao G, Khamari L, Dai L, Schmidt A, Moon SL, Walter NG. Biophysical Journal, 2025 Feb 15; 124 (3): 371a DOI:10.1016/j.bpj.2024.11.2010
    • Proceeding / Abstract / Poster
      Neurodegenerative VCP mutant and wild-type co-assembly and stoichiometry assessment by single-molecule assays
      Tang J, Dodd B, Schmidt A, Moon SL, Walter NG. Biophysical Journal, 2024 Feb 10; 123 (3): 476a DOI:10.1016/j.bpj.2023.11.2890
    • Presentation
      Regulation of RNA in stress and disease
      Moon S. 2022 Oct 26;
    • Proceeding / Abstract / Poster
      Regulation of Stress Granule Dynamicity by Valosin‐Containing Protein
      Moon S. The FASEB Journal, 2022 May 5; 36 (S1): DOI:10.1096/fasebj.2022.36.s1.0i205
    • Proceeding / Abstract / Poster
      Regulation of stress granules by valosin-containing protein
      Moon S. 2022 May 31;
    • Proceeding / Abstract / Poster
      Coupling of translation quality control and mRNA targeting to stress granules
      Moon S. 2021 Sep 9;
    • Proceeding / Abstract / Poster
      Coupling of translation quality control and mRNA targeting to stress granules
      Moon S. 2021 Jun 22;

    Featured News & Stories
    Department News

    Highlighted Publications: January - May 2026

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
         cells flowing black background grey blue dots lighting up
    Health Lab

    Researchers determine how cells prevent RNA traffic jams under stress

    New research discovers how cells prevent RNA traffic jams under stress, which could help fight disease
    Department News

    Highlighted Publications - June 2025

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - August 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News

    Highlighted Publications - May 2024

    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
         Congratulations to Lev Prasov, Tom Wilson, and Stephanie Moon on your newly awarded Research Scouts Grant!
    Department News

    Research Scouts grants awarded to Stephanie Moon, Lev Prasov, and Tom Wilson

    An agile, low-burden program which gives money to Research Scouts to invest in other scientists' bold ideas.