Wajd N Al-Holou, MD
Assistant Professor of Neurosurgery and Co-Director, CNS Tumor Registry
Medical School
University of Michigan
Neurosurgery
1500 E. Medical Center Drive, 3470 Taubman Center
Ann Arbor, MI 48109-5338
[email protected]
Neurosurgery
1500 E. Medical Center Drive, 3470 Taubman Center
Ann Arbor, MI 48109-5338
Available to mentor
Wajd N Al-Holou, MD
Assistant Professor
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Qualifications
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Clinical FellowUniversity of Texas, MD Anderson Cancer Center, Neurosurgical Oncology, United States
2016 - 2017
Postdoctoral Fellowship
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ResidencyUniversity of Michigan, Neurosurgery, Ann Arbor, United States
2009 - 2016
Residency
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Chief ResidentUniversity of Michigan, Neurosurgery, Ann Arbor, USA
2015 - 2016
Chief Resident
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MDUniversity of Michigan, Ann Arbor, MI, United States
2004 - 2009
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BSUniversity of Detroit Mercy, Detroit, United States
2000 - 2003
Recent Publications
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Terman S, Al-Holou WN, Kilburg C, Garton HJL, Maher CO. 2011 Apr 4;Proceeding / Abstract / PosterThe prevalence and natural history of pineal cysts in adults
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Syed S, Tripathy A, Ji S, Alomary Y, de la Nava Martin D, Mota M, Chakravarthy R, Huang D-L, Wang Z, Li Z, Zhang Q, Lawrence T, Wahl D, Koschmann C, Venneti S, Rehemtulla A, Al-Holou W. Neurosurgery, 2026 Mar 17; 72 (Supplement_1): 109 - 109.Journal Article393 THY1: A Therapeutically Targetable Mediator of Treatment Resistance in H3K27M Pediatric Tumors
DOI:10.1227/neu.0000000000003964_393 -
Li A, Saleh S, Sharba N, Guivatchian E, Sagher O, Sullivan SE, Heth JA, Hollon TC, Thompson BG, Pandey AS, Umemura Y, Al-Holou WN. J Cancer Res Clin Oncol, 2026 Mar 26; 152 (3):Journal ArticleMinimizing the risks of stereotactic brain biopsy in suspected central nervous system lymphoma: a retrospective database study.
DOI:10.1007/s00432-026-06458-0 PMID: PMC13022213 -
Chanoch-Myers R, Hara T, Greenwald AC, Hoefflin R, Bussema L, Weisman HR, Nieblas-Bedolla E, Gurramkonda J, Bekezhankyzy Z, Jucht A, Fernandez E, Spitzer A, Hon Fung J, Biella C, Al-Holou W, Camelo-Piragua S, Behnan J, Galli R, Wakimoto H, Suva ML, Tirosh I. Nature Communications, 2026 Mar 12;Journal ArticleA blueprint for local and distal glioblastoma invasion programs
DOI:10.1038/s41467-026-70470-8 -
Zhu Z, Kanis NC, George AE, Albdewi M, Li Y, Mujeeb AA, McClellan BL, Singh G, Liu J, Al-Holou WN, Heth JA, Welch JD, Lathia JD, Lowenstein PR, Bucala R, Castro MG. 2026 Jan 14;PreprintMIF-mediated reprogramming of myeloid lineage within the glioma tumor microenvironment impacts the efficacy of immune stimulatory gene therapy.
DOI:10.64898/2026.01.13.699283 PMID: 41648606 -
Meghdadi B, Al-Holou WN, Scott AJ, Mittal A, Liang N, Sravya P, Achreja A, O’Brien A, Do K, Wu Z, Feng J, Qi NR, Tarnal V, Venneti S, Miller CR, Sarkaria JN, Zhou W, Lawrence TS, Lyssiotis CA, Wahl DR, Nagrath D. Cell Metabolism, 2026 Jan 6; 38 (1): 228 - 246.e17.Journal ArticleDigital twins for in vivo metabolic flux estimations in patients with brain cancer
DOI:10.1016/j.cmet.2025.10.022 PMID: 41330373 -
Scott AJ, Liang N, Al-Holou WN, Xu J, O'Brien A, Lin A, Pareek V, Sha Z, Zhao Z, Yang JZ, Yang A, Kothari AU, Wilder-Romans K, Wu Z, Feng J, Korimerla N, Elaimy A, Palavalasa S, Chen J, Wang L, Zhang L, Andren AC, Sajjakulnukit P, Marini B, Heth JA, Morgan MA, Lawrence TS, Benkovic SJ, Nagrath D, Chandrasekaran S, Qi NR, Sun D, Wen B, Pai MP, Clarke N, Suresh K, Umemura Y, Lyssiotis CA, Zhou W, Wahl DR. 2025 Nov 13;PreprintAdaptive nuclear GTP synthesis promotes glioblastoma treatment resistance and is a targetable vulnerability in patients.
DOI:10.1101/2025.11.11.25340023 PMID: 41292630 -
Kiziltug E, Ravikumar V, Kulkarni R, Maddox A, Al-Holou W. Neuro-Oncology, 2025 Nov 12; 27 (Supplement_5): v13 - v13.Journal ArticleEPCO-49. SPATIAL TRANSCRIPTOMICS ILLUMINATES MECHANISMS OF MONOTHERAPY FAILURE IN GLIOBLASTOMA BY MAPPING TARGET EXPRESSION ACROSS TUMOR REGIONS
DOI:10.1093/neuonc/noaf201.0048 PMID: PMC12600365
Featured News & Stories
Department News
Brain cancer digital twin predicts treatment outcomes
A new machine-learning-based approach to mapping real-time tumor metabolism in brain cancer patients, developed at the University of Michigan, could help doctors discover which treatment strategies are most likely to be effective against individual cases of glioma.
Health Lab
I've been diagnosed with a brain tumor. Now what?
Facing a brain tumor diagnosis can be an overwhelming experience, but it’s essential to gather information that will help guide the next steps in your care. University of Michigan Health neurosurgeon Wajd Al-Holou, M.D., weighs in on the importance of understanding the diagnosis, exploring various treatment options and seeking the best medical care.
Health Lab
Aggressive brain cancer doesn’t stop woman’s positive perspective
Despite a devastating diagnosis of glioblastoma, Chris Barry is thankful for her family, friends and the care she’s receiving at Michigan Medicine.
Health Lab
After daughter’s brain surgery, mom sells art to raise money for cancer research
Nearly four and half years after her daughter’s lifesaving surgery to remove a glioma, a Michigan artist continues to raise money towards research for the treatment of cancerous brain tumors by selling her work.