Joshi J Alumkal, MD

Joshi Alumkal
Wicha Family Professor of Oncology and Professor of Internal Medicine
Medical School
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[email protected]
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Joshi J Alumkal, MD
Joshi Alumkal
Professor
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  • About

    Dr. Alumkal graduated summa cum laude from the University of Texas with a B.A. in Biology. Then, he received his medical degree from Baylor College of Medicine. He completed an internship, residency, and chief residency at UT Southwestern Medical Center. After completing a clinical fellowship in medical oncology at Johns Hopkins University, Dr. Alumkal completed a post-doctoral fellowship focused on cancer epigenetics in the Jim Herman Laboratory at Johns Hopkins. Dr. Alumkal joined the Knight Cancer Institute Prostate Cancer Research Program at Oregon Health and Science University (OHSU) in 2007 and became the co-Leader of the Program in 2013. In 2014, Dr. Alumkal was honored with the Richard T. Jones New Investigator Award for exceptional promise early in a career in biomedical research in Oregon. He was also named the inaugural holder of the Wayne D. Kuni and Joan E. Kuni Endowed Chair for Prostate Cancer Research at OHSU in 2017.

    In 2019, Dr. Alumkal re-located to the University of Michigan to lead the Genitourinary Medical Oncology Section in the Division of Hematology-
    Oncology and the Rogel Cancer Center, where he is a Professor of Internal Medicine. He was named a Rogel Cancer Center Rogel Scholar in 2019 and was elected to the American Society for Clinical Investigation that same year. Since 2020, he has been a Co-Leader of the Translational and Clinical Research Program in the Rogel Cancer Center. In 2021, Dr. Alumkal was named the inaugural Wicha Family Professor of Oncology at the University of Michigan.

    The Alumkal Laboratory’s main emphasis is to understand how tumors change and adapt in response to treatment. The most important goals of Dr. Alumkal’s studies are to identify therapies that effectively target and interdict lethal prostate cancer progression in the laboratory and to conduct innovative clinical trials designed to validate the molecular and clinical effectiveness of novel therapeutic agents.

    Center Memberships

    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Rogel Cancer Center
    • Center Member
      AI and Digital Health Innovation

    Recent Publications

    See All Publications
    • Journal Article
      Biomedical Data Manifest: A lightweight data documentation mapping to increase transparency for AI/ML
      Bottomly D, Suciu CG, Cordier B, Evans N, Poire A, Zheng C, Deininger M, Zang X, Witkiewicz A, Knudsen E, Boutros PC, Soragni A, Vlashi E, Lin C, Tran P, Chan KS, Alumkal J, Willey C, Liu T, Liu S, Goodrich DW, Druker B, Dong J, Hollingsworth M, Singh P, Koong A, Gan B, Roth J, Bivona T, Sandulache V, Myers J, Tyner JW, Hutson A, McWeeney SK. Scientific Data, 2026 Dec 1; 13 (1): DOI:10.1038/s41597-026-06670-0
      PMID: 41673000
    • Journal Article
      Combined BET bromodomain and DNMT inhibition targets critical survival pathways in transdifferentiated prostate cancer.
      Storck WK, Flores D, Kumaraswamy A, Duan Z, Chakraborty S, Zhang C, Rodansky E, Khokhani D, Swaim OA, Bedi K, Cavalcante RG, Chen C, Zhao F, Hu Y-M, Xia Z, Rebernick RJ, Cieslik M, Mannan R, Mahapatra S, Chinnaiyan AM, Udager AM, Kuleape JA, Alumkal CR, Beck HN, Nelson PS, Morrissey C, Haffner MC, Ellis L, Wang Y, Yates JA, Alumkal JJ. JCI Insight, 2026 Aug 11; DOI:10.1172/jci.insight.207543
      PMID: 42579341
    • Journal Article
      ADT combinations with radiation for prostate cancer: A systematic review and meta-analysis.
      Takayesu JSK, Xie T, Aldous J, Nasser B, Alumkal JJ, Dess RT, Reichert ZR, Schipper MJ, Spratt D, Suresh K, Jackson WC. Int J Radiat Oncol Biol Phys, 2026 Jul 19; DOI:10.1016/j.ijrobp.2026.06.3095
      PMID: 42472616
    • Preprint
      Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate Cancer
      Rebernick RJ, Hammer L, Gondal M, Parolia A, Wu Y-M, Hosseini N, Schipper M, Kumaraswamy A, McFarlane M, Cao X, Palmbos P, Caram M, Smith D, Yentz S, Hussain MH, Westbrook TC, Spratt D, Jackson WC, Alumkal JJ, Reichert Z, Robinson D, Chinnaiyan AM, Dess R, Cieslik M. 2026 Jun 24; bioRxiv, DOI:10.64898/2026.06.18.733209
    • Journal Article
      Systematic analysis of hippo pathway signaling identifies TEAD1 as a transcriptional regulator of neuroendocrine prostate cancer.
      Brown LG, Coleman IM, Chu TLH, Sayar E, Patel RA, Hanratty B, Adil M, Li D, Li Y, Nguyen HM, Sessions CJ, Sweeney EL, Alumkal JJ, da Costa RMG, Wang Y, Lin DW, True LD, Dumpit R, Corey E, Lee JK, Nelson PS, Xin L, Haffner MC, Morrissey C. Neoplasia, 2026 May 30; 78: 101321 DOI:10.1016/j.neo.2026.101321
      PMID: 42217442
    • Presentation
      A Patient-Centered Approach to Understanding Critical Determinants of Prostate Cancer Lineage Plasticity
      Alumkal J. 2026 Jun 10;
    • Journal Article
      A Phase I/II Trial of Concurrent Chemo-hormonal Enzalutamide and Cabazitaxel in Patients with Metastatic Castration-Resistant Prostate Cancer.
      Graff JN, Smith CEP, Sokolova AO, Qian DZ, Beer TM, Latour E, Bailey S, Kreitner D, Grivas P, Schweizer MT, Higano CS, Alumkal JJ, Vuky J, Yu EY, Cheng HH. Oncologist, 2026 May 11; DOI:10.1093/oncolo/oyag180
      PMID: 42112614
    • Proceeding / Abstract / Poster
      Multi-omic profiling to clarify mechanisms of therapy-induced prostate cancer lineage plasticity
      Kumaraswamy A, Ravikumar V, Zhao F, Rebernick R, Rodansky E, Tanweer A, Yates J, Udager A, Cieslik M, Reichert Z, Chinnaiyan A, Xia Z, Alumkal J. Journal of Clinical Oncology, 2026 May 29; 44 (16 suppl): DOI:10.1200/JCO.2026.44.16_suppl.e17077

    Featured News & Stories

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    Study sheds light on why some prostate tumors are resistant to treatment

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    Researchers find early driver of prostate cancer aggressiveness

    University of Michigan Health Rogel Cancer Center scientists identified a gene that plays a key role in prostate cancer cells that have transitioned to a more aggressive, treatment-resistant form. The gene can be indirectly targeted with an existing class of drugs, suggesting a potential treatment strategy for patients with aggressive subtypes of prostate cancer.