Jonathan Z Sexton
Assistant Professor of Internal Medicine
Assistant Professor of Medicinal Chemistry
College of Pharmacy
Internal Medicine, Gastroenterology & Hepatology; Department of Pharmacy, Medicinal Chemistry
1147 Catherine St., Med Sciences Bldg II
Ann Arbor, MI 48109
[email protected]

Available to mentor
Jonathan Z Sexton
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
    • Qualifications
    • Postdoctoral Fellow
      Stanford University School of Medicine, Stanford, 2006
    • PhD
      University of California, San Diego, San Diego, 2004
    • BS
      University of California, Santa Barbara, Goleta, 1999
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    Research Overview

    Non-alcoholic fatty liver disease
    NASH
    Type-II diabetes
    Obesity
    Inflammatory bowel disease
    Artificial intelligence enhanced drug discovery

    Links
    • Sexton Lab
    Recent Publications See All Publications
    • Journal Article
      Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.
      Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Proc Natl Acad Sci U S A, 2021 Sep 7; 118 (36): DOI:10.1073/pnas.2105815118
      PMID: 34413211
    • Journal Article
      Applying cell painting in non-tumorigenic breast cells to understand impacts of common chemical exposures.
      Tapaswi A, Cemalovic N, Polemi KM, Sexton JZ, Colacino JA. Toxicol In Vitro, 2024 Dec; 101: 105935 DOI:10.1016/j.tiv.2024.105935
      PMID: 39243829
    • Journal Article
      Identification and characterization of the lipoprotein N-acyltransferase in Bacteroides.
      Armbruster KM, Jiang J, Sartorio MG, Scott NE, Peterson JM, Sexton JZ, Feldman MF, Koropatkin NM. Proc Natl Acad Sci U S A, 2024 Nov 12; 121 (46): e2410909121 DOI:10.1073/pnas.2410909121
      PMID: 39495918
    • Preprint
      LUMIC: Latent diffUsion for Multiplexed Images of Cells
      Hung A, Zhang CJ, Sexton JZ, O’Meara MJ, Welch JD. bioRxiv, DOI:10.1101/2024.11.06.622339
    • Preprint
      BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III.
      Chen B, Stark DC, Jadhav PV, Lynn-Nguyen TM, Halligan BS, Rossiter NJ, Sindoni N, Shin M, Paulo JA, Chang M, Koo I, Koshkin S, Eyunni S, Ronchi P, Paulsen MT, Morlacchi P, Hanna DA, Lin J, Guerra RM, Pagliarini DJ, Banerjee R, Parolia A, Ljungman ME, Patterson AD, Mancias JD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM. 2024 Nov 5; DOI:10.1101/2024.02.02.578646
      PMID: 38352460
    • Presentation
      Pixels to Pathways: Unleashing High-Content Imaging and AI in the Quest for Novel Therapeutic Targets for Metabolic Diseases
      Sexton J. 2024 Oct 3;
    • Journal Article
      Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection.
      Reynolds MB, Klein B, McFadden MJ, Judge NK, Navarrete HE, Michmerhuizen BC, Awad D, Schultz TL, Harms PW, Zhang L, O'Meara TR, Sexton JZ, Lyssiotis CA, Kahlenberg JM, O'Riordan MX. Cell Rep, 2024 Aug 27; 43 (8): 114607 DOI:10.1016/j.celrep.2024.114607
      PMID: 39126652
    • Proceeding / Abstract / Poster
      489 Cutaneous IFN-κ expression drives nitric oxide-mediated macrophage metabolic remodeling during Staphylococcus aureus infection
      Reynolds MB, Klein B, McFadden M, Wotring J, Zhang L, Sexton J, Lyssiotis C, Kahlenberg M, O'Riordan M. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s84 DOI:10.1016/j.jid.2024.06.505