Jonathan Z Sexton, PhD

 Jonathan Sexton
Associate Professor of Internal Medicine, Medical School
Associate Professor of Medicinal Chemistry, College of Pharmacy
Office:
University of Michigan Medical School
Internal Medicine, Gastroenterology & Hepatology; Department of Pharmacy, Medicinal Chemistry
1147 Catherine St., Med Sciences Bldg II
Ann Arbor, MI 48109
Email:
[email protected]
Available to mentor
Jonathan Z Sexton, PhD
Jonathan Sexton
Associate Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

  • Manage Your Profile

    • Qualifications
    • Postdoctoral Fellow
      Stanford University School of Medicine, Stanford, United States
      2004 - 2006
      Postdoctoral Fellowship
    • PhD
      University of California, San Diego, San Diego, CA, United States
      2000 - 2004
    • BS
      University of California, Santa Barbara, Goleta, CA, United States
      1996 - 1999

    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Cell Plasticity and Organ Design

    Research Overview

    Drug Indiced Liver Injury
    MASLD/MASH
    Type-II diabetes & Obesity
    Inflammatory bowel disease
    Artificial intelligence enhanced drug discovery

    Links
    • Sexton Lab

    Recent Publications

     See All Publications
    • Journal Article
      Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.
      Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Proc Natl Acad Sci U S A, 2021 Sep 7; 118 (36): DOI:10.1073/pnas.2105815118
      PMID: PMC8433531
    • Presentation
      Ten Percent Yield: Rebuilding Drug Discovery as a Controlled Process
      Sexton J. 2026 Sep 11;
    • Proceeding / Abstract / Poster
      Integrating Patient Centric Disease Models and AI-Assisted Mechanism Discovery for Translational Drug Repurposing
      Sexton J. 2026 Aug 29; DOI:10.58647/rexpo26000208.v1
    • Preprint
      Macrophage-CD8+ T Cell Spatial Coupling Defines an Innate-Adaptive Injury Niche in Human Checkpoint Inhibitor Hepatotoxicity
      Bogdanov JM, Zhao N, Alavifard H, Kleiner DE, Fontana RJ, Stolz AA, Merchant A, Sexton JZ, Dara L. 2026 Aug 23; medRxiv, DOI:10.64898/2026.08.18.26360744
    • Journal Article
      A Direct-to-Biology Amine–Acid Amination for Rapid Phenotypic Profiling of Lysosomotropic Natural Products
      Kao Y-T, Abdelalim M, Mauro C, Douthwaite JL, McGrath A, Meyer SR, Singha S, Flores Diaz D, Wang M, Wang S, Sexton JZ, Cernak T. Journal of the American Chemical Society, 2026 Aug 18; DOI:10.1021/jacs.6c06623
    • Journal Article
      An innovative organoid model to screen for bacteria and their metabolites that protect against inflammation-induced colonic barrier disruption.
      Cady N, Meyer SR, Kim K, Lo BC, So N, Chen GY, Rosshart SP, Shah YM, Núñez G, Sexton JZ, Schmidt TM. mSphere, 2026 Jul 31; e0092625 DOI:10.1128/msphere.00926-25
      PMID: 42536076
    • Preprint
      Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity.
      Kaur H, Guevara RB, Rivera-Cuevas Y, Olafsson EB, Mayoral J, Augusto L, Guerra AJ, Patel R, Bohannon KP, Sexton JZ, Hanson PI, Weiss LM, Carruthers VB. 2026 Jul 20; DOI:10.64898/2026.07.20.739547
      PMID: 42538958
    • Preprint
      A pooled image-based CRISPR screen identifies EAF1 as a T. gondii modulator of ESCRT subversion.
      Olafsson EB, Arnold C-S, Kellermeier JA, Rimple P, Kaur H, Wang Y, Sexton JZ, Svard S, Carruthers VB, O'Meara M. 2026 Jul 9; openRxiv, DOI:10.64898/2026.07.08.737057