Jonathan Z Sexton, PhD

 Jonathan Sexton
Associate Professor of Internal Medicine, Medical School
Associate Professor of Medicinal Chemistry, College of Pharmacy
University of Michigan Medical School
Internal Medicine, Gastroenterology & Hepatology; Department of Pharmacy, Medicinal Chemistry
1147 Catherine St., Med Sciences Bldg II
Ann Arbor, MI 48109
[email protected]
Available to mentor
Jonathan Z Sexton, PhD
Jonathan Sexton
Associate Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications

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    • Qualifications
    • Postdoctoral Fellow
      Stanford University School of Medicine, Stanford, United States
      2004 - 2006
      Postdoctoral Fellowship
    • PhD
      University of California, San Diego, San Diego, CA, United States
      2000 - 2004
    • BS
      University of California, Santa Barbara, Goleta, CA, United States
      1996 - 1999

    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Cell Plasticity and Organ Design

    Research Overview

    Non-alcoholic fatty liver disease
    NASH
    Type-II diabetes
    Obesity
    Inflammatory bowel disease
    Artificial intelligence enhanced drug discovery

    Links
    • Sexton Lab

    Recent Publications

     See All Publications
    • Journal Article
      Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19.
      Mirabelli C, Wotring JW, Zhang CJ, McCarty SM, Fursmidt R, Pretto CD, Qiao Y, Zhang Y, Frum T, Kadambi NS, Amin AT, O'Meara TR, Spence JR, Huang J, Alysandratos KD, Kotton DN, Handelman SK, Wobus CE, Weatherwax KJ, Mashour GA, O'Meara MJ, Chinnaiyan AM, Sexton JZ. Proc Natl Acad Sci U S A, 2021 Sep 7; 118 (36): DOI:10.1073/pnas.2105815118
      PMID: PMC8433531
    • Journal Article
      Reconstructing EBV reactivation and DNA damage response kinetics in morphologic pseudotime.
      Tekle DG, Dobry CJ, Sexton JZ, SoRelle ED. Proc Natl Acad Sci U S A, 2026 Jun 9; 123 (23): e2609598123 DOI:10.1073/pnas.2609598123
      PMID: 42234528
    • Journal Article
      Nanoscale Direct-to-Biology Optimization of Cdk2 Inhibitors.
      Douthwaite JL, Houde DJ, Pardo E, Moran M, Baird J, Meyer SR, Mahjour B, Zhao Q, Larrow JF, Juang Y-P, Holliday MJ, Han C, Kelley B, Dunstan D, Billings K, Mader MM, Taylor AM, Sexton JZ, Boezio AA, Cernak T. J Med Chem, 2026 Apr 9; DOI:10.1021/acs.jmedchem.5c03614
      PMID: 41954971
    • Presentation
      Patient-Derived Organoids, Cell Painting, and AI: Next Generation Drug Discovery and Development
      Sexton J. 2026 Apr 23;
    • Preprint
      Salmonella Typhi asparaginase-dependent activation of GCN2 promotes bacterial killing in murine macrophages.
      Powers Z, McFadden M, Lee GY, Schultz TL, Castro Jorge L, Edwards D, Sanchez-Paiva S, Sexton J, Spindler KR, Song J, O'Riordan MX. 2026 Mar 17; DOI:10.64898/2026.03.16.712107
      PMID: 41889859
    • Preprint
      Exploring the Influence of Chemical Exposures in Breast Cancer Disparities: High-Throughput Transcriptomic Analysis in Normal Breast Cells from Diverse Donors
      Zhao N, Zhao P, Tapaswi A, Polemi K, Thong T, Sexton J, Charles S, Wicha MS, Svoboda L, Zhou X, Colacino JA. 2026 Feb 26; bioRxiv, DOI:10.64898/2026.02.23.707203
    • Preprint
      Identification and characterization of the functional LolB ortholog in <i>Bacteroides</i>
      Armbruster KM, Trickannad R, Scott NE, Pudlo NA, Wotring JW, Martens EC, Sexton JZ, Koropatkin NM. 2026 Feb 9; openRxiv, DOI:10.64898/2026.02.05.704107
    • Journal Article
      BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
      Chen B, Stark DC, Jadhav PV, Lynn-Nguyen TM, Halligan BS, Rossiter NJ, Sindoni N, Shin M, Paulo JA, Chang M, Koo I, Koshkin S, Eyunni S, Ronchi P, Paulsen MT, Greenbaum HS, Ruckert MT, Morlacchi P, Hanna DA, Lin J, Guerra RM, Liu T, Pagliarini DJ, Banerjee R, Parolia A, Ljungman ME, Patterson AD, Mancias JD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM. Molecular Cell, 2026 Jan 1; DOI:10.1016/j.molcel.2026.01.012
      PMID: 41690300