William K and Delores S Brehm Professor of Type 1 Diabetes Research
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
[email protected]
Available to mentor
Peter Arvan
Professor
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberInstitute for Healthcare Policy and Innovation
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Center MemberBiosciences Initiative
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Knupp J, Chen Y-J, Wang E, Arvan P, Tsai B. Cell Rep, 2024 Aug 10; 43 (8): 114619Journal ArticleSigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy.
DOI:10.1016/j.celrep.2024.114619 PMID: 39128005 -
Robertson CC, Elgamal RM, Henry-Kanarek BA, Arvan P, Chen S, Dhawan S, Eizirik DL, Kaddis JS, Vahedi G, Parker SCJ, Gaulton KJ, Soleimanpour SA. Mol Metab, 2024 Aug; 86: 101973Journal ArticleUntangling the genetics of beta cell dysfunction and death in type 1 diabetes.
DOI:10.1016/j.molmet.2024.101973 PMID: 38914291 -
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949Journal ArticleProinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
DOI:10.1002/pro.4949 PMID: 38511500 -
Zhang Y, Sui L, Du Q, Haataja L, Yin Y, Viola R, Xu S, Nielsson CU, Leibel RL, Barbetti F, Arvan P, Egli D. Mol Metab, 2024 Feb; 80: 101879Journal ArticlePermanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity.
DOI:10.1016/j.molmet.2024.101879 PMID: 38237895 -
Knupp J, Pletan ML, Arvan P, Tsai B. FEBS J, 2023 Dec; 290 (24): 5656 - 5673.Journal ArticleAutophagy of the ER: the secretome finds the lysosome.
DOI:10.1111/febs.16986 PMID: 37920925 -
Yeh Y-T, Sona C, Yan X, Li Y, Pathak A, McDermott MI, Xie Z, Liu L, Arunagiri A, Wang Y, Cazenave-Gassiot A, Ghosh A, von Meyenn F, Kumarasamy S, Najjar SM, Jia S, Wenk MR, Traynor-Kaplan A, Arvan P, Barg S, Bankaitis VA, Poy MN. Nat Commun, 2023 Jul 17; 14 (1): 4250Journal ArticleRestoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.
DOI:10.1038/s41467-023-39978-1 PMID: 37460527 -
Iida H, Kono T, Lee C-C, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C. Diabetologia, 2023 Nov; 66 (11): 2042 - 2061.Journal ArticleSERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
DOI:10.1007/s00125-023-05979-4 PMID: 37537395 -
Citterio CE, Kim K, Rajesh B, Pena K, Clarke OB, Arvan P. Protein Sci, 2023 Nov; 32 (11): e4784Journal ArticleStructural features of thyroglobulin linked to protein trafficking.
DOI:10.1002/pro.4784 PMID: 37717261