Peter Arvan
William K and Delores S Brehm Professor of Type 1 Diabetes Research
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
[email protected]

Available to mentor
Peter Arvan
Professor
  • Center Memberships
  • Recent Publications
    • Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Institute for Healthcare Policy and Innovation
    • Center Member
      Biosciences Initiative
    Recent Publications See All Publications
    • Journal Article
      Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
      A Avelar R, Gupta R, Carvette G, da Veiga Leprevost F, Jasti M, Colina J, Teitel J, Nesvizhskii AI, O'Connor CM, Hatzoglou M, Shenolikar S, Arvan P, Narla G, DiFeo A. Cell Death Differ, 2024 Dec; 31 (12): 1761 - 1775. DOI:10.1038/s41418-024-01378-3
      PMID: 39349971
    • Journal Article
      Role of Sec61α2 Translocon in Insulin Biosynthesis.
      Xu X, Bell TW, Le T, Zhao I, Walker E, Wang Y, Xu N, Soleimanpour SA, Russ HA, Qi L, Tsai B, Liu M, Arvan P. Diabetes, 2024 Dec 1; 73 (12): 2034 - 2044. DOI:10.2337/db24-0115
      PMID: 39325584
    • Journal Article
      Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagy.
      Knupp J, Chen Y-J, Wang E, Arvan P, Tsai B. Cell Rep, 2024 Aug 27; 43 (8): 114619 DOI:10.1016/j.celrep.2024.114619
      PMID: 39128005
    • Journal Article
      Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.
      Robertson CC, Elgamal RM, Henry-Kanarek BA, Arvan P, Chen S, Dhawan S, Eizirik DL, Kaddis JS, Vahedi G, Parker SCJ, Gaulton KJ, Soleimanpour SA. Mol Metab, 2024 Aug; 86: 101973 DOI:10.1016/j.molmet.2024.101973
      PMID: 38914291
    • Journal Article
      Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
      Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949 DOI:10.1002/pro.4949
      PMID: 38511500
    • Journal Article
      Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity.
      Zhang Y, Sui L, Du Q, Haataja L, Yin Y, Viola R, Xu S, Nielsson CU, Leibel RL, Barbetti F, Arvan P, Egli D. Mol Metab, 2024 Feb; 80: 101879 DOI:10.1016/j.molmet.2024.101879
      PMID: 38237895
    • Journal Article
      SIGMAR1/Sigma-1 receptor: a key regulator in stabilizing and translating LC3B mRNA for autophagosome formation.
      Chen Y-J, Knupp J, Wang E, Arvan P, Tsai B. Autophagy, 2024 Dec; 20 (12): 2843 - 2845. DOI:10.1080/15548627.2024.2413313
      PMID: 39369298
    • Journal Article
      Autophagy of the ER: the secretome finds the lysosome.
      Knupp J, Pletan ML, Arvan P, Tsai B. FEBS J, 2023 Dec; 290 (24): 5656 - 5673. DOI:10.1111/febs.16986
      PMID: 37920925