Matthias Truttmann PhD
Assistant Professor
[email protected]

Available to mentor
Matthias Truttmann PhD
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    Qualifications
    • Post Doctoral Research Fellow
      Boston Children's Hospital, Biochemistry / Molecular Biology / Cell Biology, 2018
    • Post Doctoral Research Fellow
      Whitehead Institute for Biomedical Research, Biochemistry / Molecular Biology / Cell Biology, 2016
    • Post Doctoral Research Fellow
      Massachusetts Institute of Technology, MIT Learning and Teaching Lab, 2015
    • Post Doctoral Research Fellow
      University of Basel, Biozentrum, Infection Biology / Systems Biology, 2011
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Precision Health Initiative
    • Center Member
      Rogel Cancer Center
    Research Overview

    Post-translational regulation of chaperone function in aging and aging-associated diseases

    Protein AMPylation in the context of protein aggregation, protein folding and protein quality control

    Genetically encoded, protein aggregation-associated diseases

    De novo generation of camelid nanobodies

    Recent Publications See All Publications
    • Journal Article
      TSWIFT, a novel method for iterative staining of embedded and mounted human brain sections
      Porter CM, Tabler S, Choi S, Truttmann MC. Scientific Reports, 2024 Dec 1; 14 (1): DOI:10.1038/s41598-024-63152-2
      PMID: 38830987
    • Journal Article
      The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans
      Hernandez-Lima MA, Champion M, Mattiola Z, Truttmann MC. Frontiers in Molecular Neuroscience, 2022 Nov 24; 15: DOI:10.3389/fnmol.2022.912734
    • Journal Article
      Explaining inter-lab variance in C. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility
      Urban ND, Cavataio JP, Berry Y, Vang B, Maddali A, Sukpraphrute RJ, Schnell S, Truttmann MC. Experimental Gerontology, 2021 Dec 1; 156: DOI:10.1016/j.exger.2021.111622
      PMID: 34793939
    • Journal Article
      Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo
      McCaul N, Porter CM, Becker A, Tang CHA, Wijne C, Chatterjee B, Bousbaine D, Bilate A, Hu CCA, Ploegh H, Truttmann MC. Journal of Biological Chemistry, 2021 Sep 1; 297 (3): DOI:10.1016/j.jbc.2021.100991
      PMID: 34419450
    • Journal Article
      Fic and non-Fic AMPylases: Protein AMPylation in metazoans
      Chatterjee BK, Truttmann MC. Open Biology, 2021 May 1; 11 (5): DOI:10.1098/rsob.210009
      PMID: 33947243
    • Journal Article
      Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code
      Nitika , Porter CM, Truman AW, Truttmann MC. Journal of Biological Chemistry, 2020 Jul 31; 295 (31): 10689 - 10708. DOI:10.1074/jbc.REV120.011666
      PMID: 32518165
    • Presentation
      Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation –implications for HSP
      Truttmann M. 2025 Mar 14;
    • Preprint
      Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in Caenorhabditis elegans.
      Urban ND, Lacy SM, Van Pelt KM, Abdon B, Mattiola Z, Klaiss A, Tabler S, Truttmann MC. 2025 Jan 19; DOI:10.1101/2025.01.14.633073
      PMID: 39868301
    Featured News & Stories worms green on left dead and on left worms in yellow alive with a divide down the middle to show seperation from one another
    Health Lab
    The scent of death?
    New research work discovers that the presence of dead members of C. elegans has profound behavioral and physiological effects, leading the worms to more quickly reproduce and shorten their lifespans.