Man (Maggie) Zhang, MD, PhD
Radiology
1500 East Medical Center Drive
Ann Arbor, MI 48109-5030
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About
I am a physician-scientist and medical ultrasound researcher with 20 years of experience developing and applying innovative ultrasound technologies to improve healthcare. My work has spanned sonoelastography, tissue characterization of prostate cancer and ablated liver lesions, acoustic droplet vaporization, high-intensity focused ultrasound, histotripsy, contrast-enhanced ultrasound, and quantitative imaging biomarkers. My current research focuses on multiparametric ultrasound imaging to assess and optimize histotripsy treatment outcomes, imaging biomarkers for severe peripheral arterial disease, clinical translation of endocavity histotripsy, and CEUS applications in renal obstruction. I have led and contributed to funded clinical and translational research projects, including an RSNA Research Scholar Award–funded prospective clinical study. I collaborate closely with clinicians, scientists, and engineers, have published multiple peer-reviewed articles, and have mentored undergraduate and graduate students as well as postdoctoral fellows.
Qualifications
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Abdominal Radiology FellowUniversity of Michigan Medical School, Ann Arbor, United States
2016 - 2017
Clinical Fellowship
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Radiology ResidencyMichigan State University, East Lansing, United States
2012 - 2016
Residency
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InternshipMichigan State University, East Lansing, United States
2011 - 2012
Internship
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FAIUMAmerican Institute of Ultrasound in Medicine, Laurel, United States
Clinical Fellowship
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PhDDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, United States
2001 - 2007
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MDNanjing Medical University, Nanjing, China
1996 - 2001
Center Memberships
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Center MemberRogel Cancer Center
Research Overview
Translational imaging research
Quantitative ultrasound biomarkers including 3D/4D volumetric blood flow measurement, photoacoustic imaging, elastography, and contrast enhanced ultrasound
Therapeutic ultrasound including imaging-guided histotripsy, HIFU, and acoustic droplet vaporization
Recent Publications
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Worlikar T, Zhang M, Yu M, Kim H, Shi J, Hall TL, Mendiratta-Lala M, Cho CS, Xu Z. Scientific Reports, 2026 Dec 1; 16 (1):Journal ArticleHistotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma
DOI:10.1038/s41598-026-48331-7 PMID: 42034785 -
Tai H, Worlikar T, Xu Z, Fowlkes J, Shi J, Zhang M. Academic Radiology, 2026 Jan 1;Journal ArticleQuantification of Histotripsy Dosage Using Machine Learning-Enhanced Ultrasound Imaging Analysis: Correlation with Histological Outcomes
DOI:10.1016/j.acra.2026.05.010 -
Worlikar T, Loudon N, Khaykin VM, Zhang M, Cho CS, Hall T, Vlaisavljevich E, Brian Fowlkes J, Parikh ND, Xu Z, Mendiratta-Lala M. Radiology Imaging Cancer, 2025 Jan 1; 7 (4):Journal ArticleDevelopment of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation
DOI:10.1148/rycan.240403 PMID: 40711384 -
Zhang M, Maji S, Aliabouzar M, Quesada C, Chiravuri A, Macpherson A, Emara Z, Abeid B, Kent III R, Midekssa F, Baker B, Franceschi R, Fabiilli M. 2024 May 8;Journal ArticleUltrasound-generated bubbles enhance osteogenic differentiation of mesenchymal stromal cells in composite collagen hydrogels
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Worlikar T, Kim H, Hall TL, Cho CS, Mendiratta-Lala M, Xu Z, Zhang M. The Journal of the Acoustical Society of America, 2025 Jan 16; 156 (4): a34 - a35.Journal ArticleHistotripsy dose selection influences immune response and tumor-free survival in an orthotopic liver tumor model
DOI:10.1121/10.0035010 -
Zaniker EJ, Zhang M, Hughes L, La Follette L, Atazhanova T, Trofimchuk A, Babayev E, Duncan FE. Biology of Reproduction, 2024 Jun 1; 110 (6): 1100 - 1114.Journal ArticleShear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease
DOI:10.1093/biolre/ioae050 PMID: 38609185 -
Maji S, Aliabouzar M, Quesada C, Macpherson A, Zhang M, Baker BM, Franceschi R, Fabiilli ML. The Journal of the Acoustical Society of America, 2024 Jul 5; 155 (3): a287 - a287.Journal ArticleLocalized compaction of collagen hydrogels using acoustic droplet vaporization promotes osteogenic differentiation of mesenchymal stem cells
DOI:10.1121/10.0027529 -
Worlikar T, Hall T, Zhang M, Mendiratta-Lala M, Green M, Cho CS, Xu Z. International Journal of Hyperthermia, 2024 Jan 1; 41 (1):Journal ArticleInsights from in vivo preclinical cancer studies with histotripsy
DOI:10.1080/02656736.2023.2297650 PMID: 38214171