Man (Maggie) Zhang, MD, PhD

Man Zhang
Clinical Associate Professor of Radiology
Medical School
Office:
University of Michigan Medical School
Radiology
1500 East Medical Center Drive
Ann Arbor, MI 48109-5030
Email:
[email protected]
Phone:
Available to mentor
Man (Maggie) Zhang, MD, PhD
Man Zhang
Clinical Associate Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile

  • About

    I am a physician-scientist and medical ultrasound researcher with 20 years of experience developing and applying innovative ultrasound technologies to improve healthcare. My work has spanned sonoelastography, tissue characterization of prostate cancer and ablated liver lesions, acoustic droplet vaporization, high-intensity focused ultrasound, histotripsy, contrast-enhanced ultrasound, and quantitative imaging biomarkers. My current research focuses on multiparametric ultrasound imaging to assess and optimize histotripsy treatment outcomes, imaging biomarkers for severe peripheral arterial disease, clinical translation of endocavity histotripsy, and CEUS applications in renal obstruction. I have led and contributed to funded clinical and translational research projects, including an RSNA Research Scholar Award–funded prospective clinical study. I collaborate closely with clinicians, scientists, and engineers, have published multiple peer-reviewed articles, and have mentored undergraduate and graduate students as well as postdoctoral fellows.

    Qualifications

    • Abdominal Radiology Fellow
      University of Michigan Medical School, Ann Arbor, United States
      2016 - 2017
      Clinical Fellowship
    • Radiology Residency
      Michigan State University, East Lansing, United States
      2012 - 2016
      Residency
    • Internship
      Michigan State University, East Lansing, United States
      2011 - 2012
      Internship
    • FAIUM
      American Institute of Ultrasound in Medicine, Laurel, United States
      Clinical Fellowship
    • PhD
      Department of Biomedical Engineering, University of Rochester, Rochester, NY, United States
      2001 - 2007
    • MD
      Nanjing Medical University, Nanjing, China
      1996 - 2001

    Center Memberships

    • Center Member
      Rogel Cancer Center

    Research Overview

    Translational imaging research
    Quantitative ultrasound biomarkers including 3D/4D volumetric blood flow measurement, photoacoustic imaging, elastography, and contrast enhanced ultrasound
    Therapeutic ultrasound including imaging-guided histotripsy, HIFU, and acoustic droplet vaporization

    Recent Publications

    See All Publications
    • Journal Article
      Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma
      Worlikar T, Zhang M, Yu M, Kim H, Shi J, Hall TL, Mendiratta-Lala M, Cho CS, Xu Z. Scientific Reports, 2026 Dec 1; 16 (1): DOI:10.1038/s41598-026-48331-7
      PMID: 42034785
    • Journal Article
      Quantification of Histotripsy Dosage Using Machine Learning-Enhanced Ultrasound Imaging Analysis: Correlation with Histological Outcomes
      Tai H, Worlikar T, Xu Z, Fowlkes J, Shi J, Zhang M. Academic Radiology, 2026 Jan 1; DOI:10.1016/j.acra.2026.05.010
    • Journal Article
      Development of Histotripsy as a Local-Regional Liver Cancer Therapy: Preclinical to Clinical Translation
      Worlikar T, Loudon N, Khaykin VM, Zhang M, Cho CS, Hall T, Vlaisavljevich E, Brian Fowlkes J, Parikh ND, Xu Z, Mendiratta-Lala M. Radiology Imaging Cancer, 2025 Jan 1; 7 (4): DOI:10.1148/rycan.240403
      PMID: 40711384
    • Journal Article
      Ultrasound-generated bubbles enhance osteogenic differentiation of mesenchymal stromal cells in composite collagen hydrogels
      Zhang M, Maji S, Aliabouzar M, Quesada C, Chiravuri A, Macpherson A, Emara Z, Abeid B, Kent III R, Midekssa F, Baker B, Franceschi R, Fabiilli M. 2024 May 8;
    • Journal Article
      Histotripsy dose selection influences immune response and tumor-free survival in an orthotopic liver tumor model
      Worlikar T, Kim H, Hall TL, Cho CS, Mendiratta-Lala M, Xu Z, Zhang M. The Journal of the Acoustical Society of America, 2025 Jan 16; 156 (4): a34 - a35. DOI:10.1121/10.0035010
    • Journal Article
      Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease
      Zaniker EJ, Zhang M, Hughes L, La Follette L, Atazhanova T, Trofimchuk A, Babayev E, Duncan FE. Biology of Reproduction, 2024 Jun 1; 110 (6): 1100 - 1114. DOI:10.1093/biolre/ioae050
      PMID: 38609185
    • Journal Article
      Localized compaction of collagen hydrogels using acoustic droplet vaporization promotes osteogenic differentiation of mesenchymal stem cells
      Maji S, Aliabouzar M, Quesada C, Macpherson A, Zhang M, Baker BM, Franceschi R, Fabiilli ML. The Journal of the Acoustical Society of America, 2024 Jul 5; 155 (3): a287 - a287. DOI:10.1121/10.0027529
    • Journal Article
      Insights from in vivo preclinical cancer studies with histotripsy
      Worlikar T, Hall T, Zhang M, Mendiratta-Lala M, Green M, Cho CS, Xu Z. International Journal of Hyperthermia, 2024 Jan 1; 41 (1): DOI:10.1080/02656736.2023.2297650
      PMID: 38214171