Zhen Xu

 labcoat
Li Ka Shing Professor of Biomedical Engineering
Professor of Biomedical Engineering, College of Engineering
Professor of Radiology
Professor of Neurosurgery, Medical School
Email:
[email protected]
Available to mentor
Zhen Xu
labcoat
Professor
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    • Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Weil Institute for Critical Care Research

    Recent Publications

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    • Journal Article
      Histotripsy dose impacts tumor cellular damage and treatment outcomes in a preclinical model of hepatocellular carcinoma
      Worlikar T, Zhang M, Yu M, Kim H, Shi J, Hall TL, Mendiratta-Lala M, Cho CS, Xu Z. Scientific Reports, 2026 Dec 1; 16 (1): DOI:10.1038/s41598-026-48331-7
      PMID: 42034785
    • Journal Article
      ASO Visual Abstract: Ultrasound-guided Histotripsy for Non-invasive Treatment of Ex Vivo Soft Tissue Tumors: Preclinical Feasibility Study.
      Messina J, Kenna E, Hubbard R, Perry K, Kim H, Mcginnis R, Malhotra G, Cornett A, Wilkowski J, Shafer AM, Yan W, Sukovich J, Soliman SB, Siegel GW, Hall T, Hewitt DB, Silk M, Xu Z, Angeles CV. Ann Surg Oncol, 2026 Oct 8; DOI:10.1245/s10434-026-20672-7
      PMID: 42848303
    • Journal Article
      Rapid, Accurate 3D Localization of Inertial Cavitation Events Using a Large Aperture, Narrowband, Receive-capable Focused Ultrasound Array
      Komaiha M, Yeats E, Hall TL, Xu Z, Sukovich JR. IEEE Transactions on Ultrasonics, 2026 Jun 13; PP (99): 1 - 1. DOI:10.1109/tuson.2026.3702874
    • Journal Article
      Evaluation of cavitation enhancements in low-boiling point (< −2°C) perfluorocarbon nanodroplet and microbubble mixtures using therapeutic ultrasound pulses
      Khan H, Dayton PA, Xu Z, Jiang X, Kim J. Ultrasonics Sonochemistry, 2026 Jun 1; 129: DOI:10.1016/j.ultsonch.2026.107850
      PMID: 41990411
    • Journal Article
      First Report of Histotripsy-Induced Survival Benefit in Murine Glioblastomas
      Duclos S, Kaovasia TP, Fox A, Cornett A, Pandey AS, Xu Z. Cancers, 2026 Feb 1; 18 (4): DOI:10.3390/cancers18040622
    • Journal Article
      Quantification of Histotripsy Dosage Using Machine Learning-Enhanced Ultrasound Imaging Analysis: Correlation with Histological Outcomes
      Tai H, Worlikar T, Xu Z, Fowlkes J, Shi J, Zhang M. Academic Radiology, 2026 Jan 1; DOI:10.1016/j.acra.2026.05.010
    • Journal Article
      Aberration correction expands the treatment envelope for histotripsy in the liver
      Yeats E, Lu N, Sukovich J, Xu Z, Hall TL. Physics in Medicine and Biology, 2025 Dec 7; 70 (23): DOI:10.1088/1361-6560/ae222c
      PMID: 41265042
    • Journal Article
      A pre-clinical MRI-guided all-in-one focused ultrasound system for murine brain studies
      Kaovasia TP, Duclos S, Gupta D, Kalayeh K, Fabiilli M, Noll DC, Sukovich J, Pandey A, Xu Z, Hall TL. Scientific Reports, 2025 Dec 1; 15 (1): DOI:10.1038/s41598-024-84078-9
      PMID: 39747938

    Featured News & Stories

         Zhen Xu, the Li Ka Shing Professor of Biomedical Engineering, a professor of radiology and neurosurgery, and a co-inventor of histotripsy, speaks at the ribbon cutting for the U-M Histotripsy Center.
    News Release

    Histotripsy research center launches to advance sound-wave-based cancer treatment

    Expanding use of a non-invasive, ultrasound-based cancer treatment is the ultimate goal of the new University of Michigan Histotripsy Center, a first-of-its-kind facility launched Sept. 10.
         Zhen Xu, Ph.D.
    News Release

    Xu named among Time magazine’s most influential in health

    U-M Health Rogel Cancer Center research member Zhen Xu, Ph.D., was selected to Time magazine’s TIME100 Health.
         Patient receiving histotripsy treatment with health care providers using equipment
    Great Minds, Greater Discoveries Stories

    Research Impact: Histotripsy

    In late 2023, the United States Food and Drug Administration (FDA) approved the use of sound waves to break down tumors — a technique called histotripsy — in humans for liver treatment, a new therapy developed at the University of Michigan and with support from the National Institutes of Health.
         cancer cell drawing in blue some yellow off white background
    Health Lab

    Histotripsy can help release HER2 from cancer tumor cells

    A study demonstrates how histotripsy could stimulate the immune system to destroy a cancer through the release of tumor antigens.
         National Academy of Inventors logo
    Medical School News

    Robert H. Bartlett, M.D., and Zhen Xu, Ph.D., named National Academy of Inventors fellows

    The National Academy of Inventors has selected U-M faculty members Robert H. Bartlett, M.S., FACS, and Zhen Xu, Ph.D., as fellows, the highest professional distinction awarded solely to inventors. They were nominated for being innovative researchers with extensive work translating discoveries into new products and technologies that are addressing some of the world’s greatest challenges
         Dr. Zhen Xu pictured on stage speaking
    News Release

    BME's Zhen Xu, Ph.D. receives multiple honors for pioneering work in non-invasive cancer treatment

    Zhen Xu, Ph.D. inducted as 2024 Fellow by the National Academy of Inventors (NAI) and a Fellow by the Institute of Electrical and Electronics Engineers (IEEE), underscoring her significant contributions to technology and patient care.