Jeffrey L Platt, MD
Professor Emeritus/A in Service of Surgery
Professor Emeritus of Microbiology and Immunology
[email protected]

Available to mentor

Jeffrey L Platt, MD
Emeritus/a in Service
  • About
  • Links
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Jeffrey L Platt, MD, is Professor of Surgery and Microbiology & Immunology, and head of the Transplantation Biology Program. He received his medical training at the University of Southern California, Children’s Hospital of Los Angeles and the University of Minnesota. He has held professorships at Duke University and the Mayo Clinic. He has published more than 500 papers and five books. He has received Clinician Scientist and Established Investigator awards from the American Heart Association, a MERIT award from the National Institutes of Health and election to the Association of American Physicians and Institute of Medicine of the National Academy of Sciences.

    Links
    • Transplantation Biology Program
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Dr. Platt's research focuses on the biology of experimental surgery, particularly transplantation and related fields. The research poses such questions as how does the immune system become activated by microorganisms and by foreign cells and how does the activated immune system control the growth of microorganisms and injure transplants. As one important line of inquiry, Dr. Platt investigates the mechanisms through which a graft, or any tissue, acquires resistance to immune-mediated injury, a phenomenon Dr. Platt originally described and named "accommodation." Accommodation may be vital to the survival and function of organ transplants and to the eradication of infectious organisms without unwanted destruction of tissue. As another example, Dr. Platt investigates how diverse repertoires of B cells and T cells develop, how they are maintained, and how immunity can be reconstituted for treatment of immunodeficiency, chronic viral infection, and cancer. Also investigated are endogenous mechanisms of activation and control of toll like receptor function in health and disease, interaction of stem cells and engineered tissues with the immune system and the mechanisms and implications of cell fusion.

    Recent Publications See All Publications
    • Preprint
      Complement C3d enables protective immunity capable of distinguishing spontaneously transformed from non-transformed cells.
      Platt JL, Zhao C, Chicca J, Pianko MJ, Han J, The S, Rao A, Keller E, de Mattos Barbosa MG, Naing L, Pasieka-Axenov T, Axenov L, Schaefer S, Farkash E, Cascalho M. 2024 Jul 31; DOI:10.1101/2024.07.31.606044
      PMID: 39211250
    • Journal Article
      Somatic Cell Fusion in Host Defense and Adaptation.
      Platt JL, Cascalho M. Results Probl Cell Differ, 2024 71: 213 - 225. DOI:10.1007/978-3-031-37936-9_11
      PMID: 37996680
    • Journal Article
      Ixazomib for Desensitization (IXADES) in Highly Sensitized Kidney Transplant Candidates: A Phase II Clinical Trial.
      Wilson N, Reese S, Ptak L, Aziz F, Parajuli S, Jucaud V, Denham S, Mishra A, Cascalho M, Platt JL, Hematti P, Djamali A. Kidney360, 2023 Jun 1; 4 (6): e796 - e808. DOI:10.34067/KID.0000000000000113
      PMID: 36951387
    • Journal Article
      Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
      Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Sci Transl Med, 2023 Feb 8; 15 (682): eade3782 DOI:10.1126/scitranslmed.ade3782
      PMID: 36753565
    • Journal Article
      Accommodation in allogeneic and xenogeneic organ transplantation: Prevalence, impact, and implications for monitoring and for therapeutics.
      Platt JL, Cascalho M. Hum Immunol, 2023 Jan; 84 (1): 5 - 17. DOI:10.1016/j.humimm.2022.08.001
      PMID: 36244871
    • Journal Article
      TNFRSF13B in B cell responses to organ transplantation.
      Cascalho M, Platt JL. Hum Immunol, 2023 Jan; 84 (1): 27 - 33. DOI:10.1016/j.humimm.2022.09.006
      PMID: 36333165
    • Journal Article
      Xenotransplantation in transition.
      Platt JL. Hum Immunol, 2023 Jan; 84 (1): 1 - 4. DOI:10.1016/j.humimm.2022.11.007
      PMID: 36529614
    • Journal Article
      Allogeneic and xenogeneic lymphoid reconstitution in a RAG2 -/- IL2RG y/- severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation.
      Sper RB, Proctor J, Lascina O, Guo L, Polkoff K, Kaeser T, Simpson S, Borst L, Gleason K, Zhang X, Collins B, Murphy Y, Platt JL, Piedrahita JA. Front Vet Sci, 2022 9: 965316 DOI:10.3389/fvets.2022.965316
      PMID: 36311661