Huda Akil

 portrait of Huda Akil
Gardner C Quarton Distinguished University Professor of Neurosciences
Gardner C Quarton Legacy Professor of Neurosciences in the Molecular and Behavioral Neurosciences Institute
Professor of Psychiatry and Research Professor
Michigan Neuroscience Institute
Medical School
Email:
[email protected]
Available to mentor
Huda Akil
portrait of Huda Akil
Research Professor
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    • Center Memberships
    • Center Member
      Eisenberg Family Depression Center

    Recent Publications

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    • Journal Article
      Stress fitness: A neuroscientific approach to building emotional resilience
      Akil H, Maras PM, Turner CA. Neuron, 2026 Jul 1; 114 (13): 2298 - 2314. DOI:10.1016/j.neuron.2026.03.032
      PMID: 42066776
    • Journal Article
      The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex
      Geoghegan E, Hagenauer M, Hernandez E, Espinoza S, Flandreau E, Nguyen P, Santiago A, Bhuiyan MR, Mensch S, Watson Jr S, Akil H, Hen R. Journal of Neurochemistry, 2026 Jul 1; In Press: DOI:10.1111/jnc.70502
    • Preprint
      A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human Primates.
      Bhuiyan MR, Hagenauer MH, Geoghegan E, Flandreau E, Watson S, Akil H. 2026 Jun 29; DOI:10.64898/2026.06.24.734301
      PMID: 42427766
    • Journal Article
      Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague–Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits
      Chitre AS, Hebda-Bauer EK, Emery MA, Li F, Nguyen KM, Wang Y, Cheng R, Polesskaya O, Watson SJ, Li J, Akil H, Palmer AA. Genes Brain and Behavior, 2026 Jun 1; 25 (3): DOI:10.1111/gbb.70053
      PMID: 42145201
    • Preprint
      The Effects of Antidepressants on the Hippocampus: A Meta-Analysis of Public Transcriptional Profiling Data
      Geoghegan E, Hagenauer M, Hernandez E, Espinoza S, Flandreau E, Nguyen P, Bhuiyan M, Mensch S, Watson Jr S, Akil H, Hen R. 2025 Apr 29; DOI:10.1101/2025.04.21.648805
    • Preprint
      Differential acquisition of cocaine and heroin self-administration in a rat model of internalizing versus externalizing temperament.
      Emery MA, Parsegian A, Koonse S, Hebda-Bauer EK, Lee K, Luma BD, Chang SE, Becker J, Flagel SB, Watson SJ, Akil H. 2026 Apr 13; DOI:10.64898/2026.04.09.717453
      PMID: 42039450
    • Preprint
      The Neuroendocrine Profile During the Trier Social Stress Test in College Freshmen Offers Insights into the Emergence of Anxiety and Depression Symptoms.
      Khalil H, Turner CA, Murphy-Weinberg V, Gates L, Li F, Onica A, Arakawa K, Weinberg L, Stack C, Lopez JF, Watson SJ, Akil H. 2026 Mar 10; DOI:10.64898/2026.01.27.26344962
      PMID: 41646822
    • Journal Article
      Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.
      Chitre AS, Hebda-Bauer EK, Emery MA, Li F, Nguyen K-M, Wang Y, Cheng R, Polesskaya O, Watson SJ, Li J, Akil H, Palmer AA. bioRxiv, 2026 Feb 19; DOI:10.64898/2026.02.18.706481
      PMID: PMC12934780

    Featured News & Stories

         portrait of Huda Akil
    Department News

    Dr. Huda Akil speaks at National Institutes of Health

    Dr. Akil invited to speak at highest-profile lecture program at the National Institutes of Health (NIH)
         Illustration of person swinging from a tree on a swing made of DNA. A version of the same person is sitting at the base of the tree with their head down.
    Medicine at Michigan

    Searching for the biology of mental illness

    For half a century, Michigan Medicine researchers have been working to understand why we feel the way we feel. Their findings have offered hope to patients with mental health conditions from anxiety and depression to addiction and bipolar disorder.
         Lori L. Isom, Ph.D., Sally A. Camper, Ph.D., Karin Muraszko, M.D., Lori J. Pierce, M.D., Dee E. Fenner, M.D.
    Medical School News

    Communication, ‘rethinking our system’ are keys to future of biomedical science

    If biomedical science is to survive, researchers must communicate better about the discoveries and promise of science and medicine, as well as their complexities and limits, and the critical importance of both in serving the public good. Such communication is necessary in times of crisis, like now, according to Huda Akil, Ph.D., one of the Medical School’s top biomedical researchers, both in longevity (47 years at the U-M) and success (2023 recipient of the National Medal of Science). She delivered the keynote address at the third annual Celebration of Women in Academic Medicine and Science on Feb. 5.
         Sally A. Camper, Ph.D., and Lori J. Pierce, M.D.
    Medical School News

    Sally A. Camper, Ph.D., and Lori J. Pierce, M.D., to receive Muraszko Award

    Two Medical School leaders are being honored for their efforts to help women forge successful careers in academic medicine and science. Sally A. Camper, Ph.D., and Lori J. Pierce, M.D., will receive the Karin Muraszko, M.D., Advancing Women in Academic Medicine and Science Award on Feb. 5 at the third annual Celebration of Women in Academic Medicine and Science.